1. Diagnostic Value of Procalcitonin for Bacterial Meningitis in Children: A Comparison Analysis Between Serum and Cerebrospinal Fluid Procalcitonin Levels
- Author
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Ting Gao, Li Zhang, Lei Zhu, Li-Jun Xu, Xiang-Hong Zhou, Jinhua Meng, Rui Huang, Jie Wen, and Lan Ma
- Subjects
Male ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Serum albumin ,Sensitivity and Specificity ,Gastroenterology ,Procalcitonin ,Meningitis, Bacterial ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Cerebrospinal fluid ,030225 pediatrics ,Internal medicine ,parasitic diseases ,medicine ,Viral meningitis ,Humans ,CSF albumin ,Receiver operating characteristic ,biology ,business.industry ,Albumin ,Reproducibility of Results ,bacterial infections and mycoses ,medicine.disease ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,biology.protein ,Female ,business ,Meningitis ,hormones, hormone substitutes, and hormone antagonists - Abstract
The aim of this study was to analyze and compare procalcitonin (PCT) levels in serum and cerebrospinal fluid (CSF) as tools for detecting bacterial meningitis (BM) in children. Serum and CSF PCT levels as well as albumin index (AI = CSF albumin/serum albumin × 1000) were measured from 29 BM, 25 viral meningitis (VM), and 47 non-meningitis patients. Differences between groups only for CSF PCT were significant. A stronger positive correlation between CSF PCT level and AI was observed in the BM patients ( R = 0.68, P < .001). As a predictor of BM, the area under the receiver operating characteristics curve for CSF PCT was greater than that of serum PCT (0.76 vs 0.67, P < .05) and a cutoff of ⩾0.085 ng/mL achieved 55.17% sensitivity and 95.83% specificity. High levels of CSF PCT may indicate loss of integrity of the blood-brain barrier; only CSF PCT has a diagnostic value for BM in children suspected meningitis.
- Published
- 2018
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