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Introduction Gastroschisis is a congenital malformation characterized by intestinal herniation through an abdominal wall defect. Despite its unknown pathogenesis, known risk factors include maternal smoking, alcohol use, and young maternal age. Previous work has shown that gastroschisis is associated with placental delayed villous maturation, and the goal of this study was to assess for additional associated placental pathologies that may help clarify the pathogenesis of gastroschisis. Methods We conducted a retrospective slide review of 29 placentas of neonates with gastroschisis. Additionally, we reviewed pathology reports from one control group of 30 placentas with other congenital malformations. Gross and histological data were collected based on a standardized rubric. Results Gastroschisis was associated with increased placental fetal vascular malperfusion (FVM) in 62% of cases (versus 0% of controls, p Conclusion Our study demonstrates an association between gastroschisis and FVM. While FVM could be the consequence of vascular disruption due to the ventral location of gastroschisis, it could also reflect estrogen-induced thrombosis in early pregnancy. Further research is needed to separate these possibilities and determine the cause of the placental FVM observed in gastroschisis.

Epileptic seizures, sleep, and circadian timing share bilateral interactions, but concerted work to characterize these interactions and to leverage them to the advantage of patients with epilepsy remains in beginning stages. To further the field, a multidisciplinary group of sleep physicians, epileptologists, circadian timing experts, and others met to outline the state of the art, gaps of knowledge, and suggest ways forward in clinical, translational, and basic research. A multidisciplinary panel of experts discussed these interactions, centered on whether improvements in sleep or circadian rhythms improve decrease seizure frequency. In addition, education about sleep was lacking in among patients, their families, and physicians, and that focus on education was an extremely important “low hanging fruit” to harvest. Improvements in monitoring technology, experimental designs sensitive to the rigor required to dissect sleep versus circadian influences, and clinical trials in seizure reduction with sleep improvements were appropriate.

The emergence of Human Factors as a discipline is often traced to pioneering efforts tackling military issues in World War II. Rapid technological advances raised fundamental questions around human performance. Approaches, solutions, and advances in the science soon spread outside of their original military contexts. Current and emerging technologies, and also new challenges for human-machine systems, means Human Factors remains central to military effectiveness, while producing outcomes with broader potential impact. This panel discussion will examine an array of contributions to the Office of Naval Research program on Command Decision Making. The session will explore methods to understand and enhance decision making through: (1) Addressing gaps that demand further foundational knowledge to produce empirical generalizations, models, and theories as basis for future guidelines, principles, specifications, and doctrine for Navy Command Decision Making; (2) Applications of existing knowledge within specific contexts to address current /future real world Navy decision making challenges.

Gastroschisis is a congenital abnormality characterized by visceral herniation through an abdominal wall defect. While the cause of gastroschisis is unknown, it has been linked to risk factors including young maternal age, smoking, and alcohol use during pregnancy. To date, the only established placental correlate is amniocyte vacuolization. Based on our clinical experience, we hypothesized that delayed villous maturation (DVM) is also associated with gastroschisis. We conducted a retrospective slide review of 23 placentas of neonates with gastroschisis. Additionally, we selected 2 control groups of placentas: 1 with a previous diagnosis of DVM and 1 with normal villous morphology. All placentas were randomized and reviewed by 2 perinatal pathologists, who were blinded to the group; DVM and amniocyte vacuolization were assessed. Gastroschisis was associated with increased placental DVM in 65.2% of cases (vs 13.6% of controls; P = .0007) and increased amniocyte vacuolization in 52.2% of cases (vs 9.1% of controls; P = .003) compared to the control group. Based on the normal and DVM groups, kappa agreement between current slide review and initial pathology diagnosis was 0.419, indicating moderate agreement. Our study shows that gastroschisis is associated with placental DVM. This association may be due to (1) a common upstream factor contributing to both gastroschisis and DVM or (2) DVM may be a consequence of the altered placental and amniotic environment in the context of gastroschisis.

This article presents a case study of how American soil scientists encountered the increasing demands to prove the social utility of their scientific work in the first half of the twentieth century and how this influenced the professional rivalry and competition among them. Previous historical studies of agricultural science in the period have not overlooked the increasing demands for applicability that agricultural scientists were faced with at the time. However, in describing the response of agricultural scientists to these demands, research has focused on the content of their scientific work, that is, their methods, empirical interests, and theories. This study, by contrast, explores how the debates on applied vs. fundamental/basic research in American agricultural science were closely linked to the question of how scientific knowledge could be made understood to laymen and practitioners.

Peritoneal dialysis (PD) was introduced in China later than in most Western countries, and PD research activity was quite limited until the 1990s. However, in the 2000s, and even more so during the last decade, there has been an unsurpassed increase in the number of PD patients, paralleled by a substantial increase in PD research activity reflected by an increasing number of PD papers from China. In this brief review, we describe some of the factors that may explain the dramatic developments in PD research in mainland China, such as the focus on basic research using scientific approaches that subsequently could be applied also in clinical studies. Another important factor was the growing interactions with international PD research centers in Hong Kong and in Western countries. Thanks to strong support from Chinese national and regional funding sources, a growing number of young Chinese researchers went to key international PD centers to learn about novel advanced research techniques. This paved the way for long-lasting, productive collaborations with benefits also for the foreign host institutions. Finally, we present some current research projects, including basic research that may contribute to the understanding of mechanisms behind complications such as peritonitis, and clinical projects aiming at improving PD management guidelines and better understanding of the potential of PD in China. Because of the size of the PD population, now the largest in the world, and the increasing number, and quality, of researchers in the PD field, PD research in China is destined to be a major contributor to advancements in PD in the near future.

Korea has been in a transition from catching-up to post-catching-up period. In this circumstance, the strengthening of basic research is one of the important strategies. This research investigates the main factors influencing research performance through the international joint research (IJR). The literature about determinants of performance of R&D and the effect of IJR to the performance is reviewed. The research performance of IJR will be investigated in comparison with IJR programme and general R&D programme as a result of international and domestic research activities. The comparison about research performance will be performed using independent samples test on the modified impact factor of papers. The main factors influencing the performance are investigated in terms of research budget, capacity, number of researchers and international collaboration on the basis of previous researches. The main finding is that the research capacity is basic requirement to increase the modified impact factor and the main factors influencing research performance through IJR are the network size and the number of contact in this research. Its recommendations, in accordance with this finding, are as follows. The government should support researcher to have more and easier contact with foreign researchers in terms of budget and programme structure and institutional improvement, including evaluation system. The additional budget on the existing programme and easy usage of research budget in the IJR are the good ways to promote the IJR activities through renovation of basic R&D programme structure. The additional credit to the research groups with bigger research networks should be considered in the selection process and ex-post evaluation process. Long-term and sustainable support for the research is the basic requirement to improve the capacity of researchers and obtain better research performance.

Over 100 years have passed since Binet and Simon proposed scales for assessment of intelligence of children to predict academic success and failure. The extension of these assessments to adults largely resulted from efforts of psychologists to provide insights for military selection in World War I. At the time, relatively little thought was given to how adult intelligence might differ from child and adolescent intelligence. Traditional approaches for assessing adult intelligence have largely survived. However, there is little reference to adult intellectual functioning outside of laboratory-based tasks and clinical assessments of pathology. The result is that there are insufficient criterion measures for adult intelligence. Moreover, researchers have shifted from treating intelligence tests as predictors to treating them as criterion measures. The result is a disconnection between basic research on one hand and understanding adult intelligence on the other hand. This lack of connection is a serious impediment for predicting individual differences in performance on tasks which adults perform in their day-to-day work and nonwork lives. This article explores how the field has come to the current situation, and what remedies might be explored. Ultimately, a fundamental reexamination of how adult intelligence is studied and applied is suggested.

Introduction. In this article, we explored the hypothesis that the long noncoding RNA, Nespas, promotes osteoarthritis (OA) by supporting abnormal lipid metabolism in human chondrocytes. Materials and Methods. Human articular chondrocytes from osteoarthritis patients were used and expression level of Nespas were determined by real-time polymerase chain reaction. Introduction of Nespas and Nespas-associated genes/miRNAs were performed by using a lentiviral system. The effect of Nespas on mitochondrial function was determined by staining mitochondria and analyzing mitopotential and mitochondrial genes. Moreover, to identify the responsible molecules in Nespas-induced pathogenesis, profiling of peroxisomal genes and miRNAs were applied and interactome analysis was performed. Results. Highly elevated levels of Nespas and Acyl-CoA synthetase 6 (ACSL6) were observed in OA patients. Both Nespas overexpression and ACSL6 upregulation into human chondrocytes induced typical OA characteristics, such as downregulation of type II collagen; upregulation of type I collagen, metalloproteinase 13, and caspase-1 and -3; and dysfunction of mitochondria and peroxisome. Co-expression of Nespas and ACSL6 siRNA reduced caspase-1 and -3 levels. Moreover, Nespas overexpression significantly suppressed levels of miR-291a-3p, -196a-5p, -23a-3p, -24-3p, and let-7a-5p, and these miRs are known to potentially target ACSL6 according to ingenuity pathway analysis. We also confirmed that these miRs were significantly suppressed in human OA chondrocytes. Overexpression of miR-291a-3p, -196a-5p, -23a-3p, -24-3p, or let-7a-5p in the presence of Nespas suppressed levels of ACSL6, caspase-1 and -3. Discussion. Overall, we suggest that elevated Nespas level in OA are associated with OA pathogenesis by suppressing miRs targeting ACSL6 and subsequent ACSL6 upregulation.

Introduction: Recent clinical evidence suggests that total hip arthroplasty (THA) provides improved clinical outcomes as compared to hemiarthroplasty (HA) for displaced femoral neck fractures in elderly individuals. However, THA is still utilized relatively infrequently. Few studies have evaluated the factors affecting utilization and the role socioeconomics plays in THA versus HA. Methods: In the United States, the National Inpatient Sample (NIS) database was used to identify patients treated surgically for femoral neck fracture, between 2009 and 2010. Patients were identified using International Classification of Diseases, Ninth Revision, codes for closed, transcervical femoral neck fractures and closed fractures at unspecified parts of the femoral neck. All candidate predictors of THA versus HA were entered into a multilevel mixed-effect regression model. Results: Older patient age, being Asian or Pacific Islander, and having Medicaid payer status were all associated with lower odds of receiving THA. Patients with private insurance including Health Maintenance organization (HMO) had higher odds of THA as did patients with other insurance. Odds of THA were significantly lower among patients in teaching hospitals and higher at hospitals with greater THA volume. Discussion: Ethnicity, payer status, hospital size, and institutional THA volume were all associated with the utilization of THA versus HA in the treatment of geriatric femoral neck fractures. Level of Evidence: Level III Retrospective Cohort study.

Childhood epileptic encephalopathies are age-dependent disorders of the brain whose hallmarks include loss of neurologic function over time, abnormal electroencephalographic findings, and seizures. Ictal and interictal electrographic activity are conjointly thought to be at the root of the often devastating neuropsychological deterioration, which is specific to the maturing brain. The goals of treatment are not only to control seizures, but also to prevent or reverse neurologic loss of function. In general, time is of the essence in diagnosis, and experienced specialists should promptly design a treatment plan. Hormonal and immune therapies are at the forefront of treatment in many cases, with traditional antiepileptic drugs and surgery (when an identifiable lesion is present) playing a limited role. However, gold standard evidence for treatment of epileptic encephalopathies remains limited. Ongoing clinical and basic research may lead to better understanding of these catastrophic conditions and to better and more effective therapies.

Chondroprotection in Models of Cartilage Injury by Raising the Temperature and Osmolarity of Irrigation Solutions Noha M. Eltawil, Saima Ahmed, Luke H. Chan, A. Hamish R. W. Simpson, Andrew C. Hall First Published January 30, 2017 research-article PDF download for Chondroprotection in Models of Cartilage Injury by Raising the Temperature and Osmolarity of Irrigation Solutions Article Information SAGE Choice Open Access Creative Commons Attribution 3.0 License Abstract Objectives During arthroscopic or open joint surgery, articular cartilage may be subjected to mechanical insults by accident or design. These may lead to chondrocyte death, cartilage breakdown and posttraumatic osteoarthritis. We have shown that increasing osmolarity of routinely used normal saline protected chondrocytes against injuries that may occur during orthopedic surgery. Often several liters of irrigation fluid are used during an orthopedic procedure, which is usually kept at room temperature, but is sometimes chilled. Here, we compared the effect of normal and hyperosmolar saline solution at different temperatures on chondrocyte viability following cartilage injury using in vitro and in vivo models of scalpel-induced injury. Design Cartilage injury was induced in bovine osteochondral explants and the patellar groove of rats in vivo by a single pass of a scalpel blade in the presence of normal saline (300 mOsm) or hyperosmolar saline solution (600 mOsm, sucrose addition) at 4°C, 21°C, or 37°C. Chondrocytes were fluorescently labeled and visualized by confocal microscopy to assess cell death. Results Hyperosmolar saline reduced scalpel-induced chondrocyte death in both bovine and rat cartilage by ~50% at all temperatures studied (4°C, 21°C, 37°C; P < 0.05). Raising temperature of both irrigation solutions to 37°C reduced scalpel-induced cell death (P < 0.05). Conclusions Increasing the osmolarity of normal saline and raising the temperature of the irrigation solutions to 37°C reduced chondrocyte death associated with scalpel-induced injury in both in vitro and in vivo cartilage injury models. A hyperosmolar saline irrigation solution at 37°C may protect cartilage by decreasing the risk of chondrocyte death during mechanical injury.

This study examines factors affecting the performance of basic research in South Korea. Creative Research Program (CRP), which is one of the major basic research programmes, is a study target. The survey of N = 120 researchers from universities and research institutes was conducted in 2010. Basic research performance which is the dependent variable was measured by subjective survey questions. The data were analysed using factor analysis and multiple regression. The result shows that leadership is the most important factor affecting the basic research performance based on the regression coefficient (β). Knowledge sharing, autonomy, collaboration and creativity in sequence were also statistically valuable factors that impact on the performance of basic research in South Korea.

Upon adequate stimulation, real-time maps of cortical hemodynamic responses can be obtained by functional near-infrared spectroscopy (fNIRS), which noninvasively measures changes in oxygenated and deoxygenated hemoglobin after positioning multiple sources and detectors over the human scalp. This review is aimed at giving a concise and simple overview of the basic principles of fNIRS including features, strengths, advantages, limitations, and utility for evaluating human behavior. The transportable/wireless commercially available fNIRS systems have a time resolution of 1 to 10 Hz, a depth sensitivity of about 1.5 cm, and a spatial resolution up to 1 cm. fNIRS has been found suitable for many applications on human beings, either adults or infants/children, in the field of social sciences, neuroimaging basic research, and medicine. Some examples of present and future prospects of fNIRS for assessing cerebral cortex function during human behavior in different situations (in natural and social situations) will be provided. Moreover, the most recent fNIRS studies for investigating interpersonal interactions by adopting the hyperscanning approach, which consists of the measurement of brain activity simultaneously on two or more people, will be reported.

Objective: Fetal alcohol spectrum disorders (FASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) are associated with a range of neurocognitive impairments. Executive functioning deficits are a hallmark feature of both disorders. Method: The present meta-analysis was undertaken to disentangle the behavioral phenotype of FASD and ADHD by quantitatively differentiating executive functioning differences between these two groups. The current meta-analysis reviews 15 studies comparing children and adolescents with FASD and ADHD to typically developing (TD) samples, on a variety of executive function measures. Results: Results indicate that when compared with TD samples, FASD and ADHD samples demonstrate significant executive function deficits ( d = 0.82 and d = 0.55, respectively). In addition, FASD samples experience significantly greater deficits when compared with ADHD samples ( d = 0.25). Results were moderated by IQ and socioeconomic status. Conclusion: These findings further our understanding of the cognitive differences between FASD and ADHD samples and have the potential to influence future basic research, assessment, and intervention.

Systemic sclerosis (SSc) was one of the major topics covered during the 2015 American College of Rheumatology meeting. Selected abstracts related to basic research reported the identification of new relevant targets including interferon regulatory factor 7 (IRF7), long coding RNAs, C-terminal domain of endostatin, M2 macrophages and keratinocytes. Several new compounds, including abatacept, nintedanib and soluble guanylate cyclase stimulators, displayed potent antifibrotic effects in complementary animal models of experimental dermal fibrosis. Clinical aspects of the disease were also largely covered, with a specific focus on cardiac biomarkers and the relationship between cancer and SSc. The results of several clinical trials were also presented, including the comparison between cyclophosphamide and mycophenolate mofetil in the scleroderma lung study-2 and the effects of riociguat in patients with pulmonary arterial hypertension associated with connective tissue diseases.

Background: Circulating tumor cells (CTCs) hold huge potential for both clinical applications and basic research into the management of cancer, but the relationship between CTC count and cervical cancer prognosis remains unclear. Therefore, research on this topic is urgently required. Objective: This study investigated whether CTCs were detectable in patients with cervical cancer and whether CTC count was an indicator of prognosis. Methods: We enrolled 107 patients with pathologically confirmed cervical cancer. CTCs were detected after radiotherapy or concurrent cisplatin-containing chemotherapy in all patients. We evaluated all medical records and imaging data as well as follow-up information to calculate progression-free survival (PFS). PFS was defined as the time until first diagnosis of tumor progression or death. We also analyzed the relationship between CTC count and patient age, disease stage, histological differentiation, tumor size, and pathological type. Results: CTCs were identified in 86 of 107 patients (80%), and the CTC count ranged from 0 to 27 cells in 3.2 mL blood. The median progression-free survival (PFS) was 43.1 months. Patients in which CTCs were detected had a significantly shorter PFS than CTC-negative patients (P = 0.018). Multivariate analysis indicated that CTC count was an independent negative prognostic factor for survival. However, no correlation was observed between CTC count and patient age, disease stage, histological differentiation, tumor size, and pathological type. Conclusion: CTC count is an independent negative prognostic factor for cervical cancer.

Cardiovascular disease is currently not adequately managed and has become one of the main causes of morbidity and mortality worldwide. Current therapies are inadequate in terms of preventing its progression. There are several limitations, such as poor oral bioavailability, side effects, low adherence to treatment, and high dosage frequency of formulations due to the short half-life of the active ingredients used, among others. This review aims to highlight the most relevant aspects of the relationship between the cardiovascular system and the endocannabinoid system, with special attention to the possible translational effect of the use of anandamide in cardiovascular health. The deep and detailed knowledge of this interaction, not always beneficial, and that for years has gone unnoticed, is essential for the development of new therapies. We discuss the most recent and representative results obtained in the field of basic research, referring to the aforementioned subject, emphasizing fundamentally the main role of nitric oxide, renal physiology and its deregulation in pathological processes. Fil: Martín Giménez, Virna Margarita. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Cs. de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación En Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Noriega, Sandra. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Cs. de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación En Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Kassuha, Diego Enrique. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Cs. de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación En Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Fuentes, Lucia Beatriz. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina

Current justification by linear no-threshold (LNT) cancer risk model advocates for its use in low-dose radiation risk assessment is now mainly based on results from flawed and unreliable epidemiologic studies that manufacture small risk increases (ie, phantom risks). Four such studies of nuclear workers, essentially carried out by the same group of epidemiologists, are critiqued in this article. Three of the studies that forcibly applied the LNT model (inappropriate null hypothesis) to cancer mortality data and implicated increased mortality risk from any radiation exposure, no matter how small the dose, are demonstrated to manufacture risk increases for doses up to 100 mSv (or 100 mGy). In a study where risk reduction (hormetic effect/adaptive response) was implicated for nuclear workers, it was assumed by the researchers to relate to a “strong healthy worker effect” with no consideration of the possibility that low radiation doses may help prevent cancer mortality (which is consistent with findings from basic radiobiological research). It was found with basic research that while large radiation doses suppress our multiple natural defenses (barriers) against cancer, these barriers are enhanced by low radiation doses, thereby decreasing cancer risk, essentially rendering the LNT model to be inconsistent with the data.

A robust body of literature analyzes the shift of academic science toward more business-oriented models. This paper presents the findings of an empirical study investigating basic scientists’ attitudes toward publicly funded basic research at the Harvard Medical School and affiliated institutions. The study finds that scientists at the Harvard Medical School construe publicly funded basic research as inquiries that, whether use oriented or not, must be governed by the cognitive and social norms of the traditional mode of knowledge production (mode 1 paradigm). They recognize that academic science is vulnerable to access by external capital but maintain that it remains distinct from research done in the private sector. Overall, the study demonstrates that important segments of academia have preserved a traditional approach to knowledge production, which is yet to be transformed by the entrepreneurial turn.

ObjectiveHyaline cartilage degenerative pathologies induce morphologic and biomechanical changes resulting in cartilage tissue damage. In pursuit of therapeutic options, electrical and mechanical stimulation have been proposed for improving tissue engineering approaches for cartilage repair. The purpose of this review was to highlight the effect of electrical stimulation and mechanical stimuli in chondrocyte behavior.DesignDifferent information sources and the MEDLINE database were systematically revised to summarize the different contributions for the past 40 years.ResultsIt has been shown that electric stimulation may increase cell proliferation and stimulate the synthesis of molecules associated with the extracellular matrix of the articular cartilage, such as collagen type II, aggrecan and glycosaminoglycans, while mechanical loads trigger anabolic and catabolic responses in chondrocytes.ConclusionThe biophysical stimuli can increase cell proliferation and stimulate molecules associated with hyaline cartilage extracellular matrix maintenance.

Objective: The aim of this study was to determine the impact of sideways visuomotor rotations between 0° and 180° on novice performance in a laparoscopic simulator. Background: The laparoscopic surgical environment often involves visuomotor rotations because the laparoscope may be placed to the surgeon’s side. Basic research by Cunningham indicated that visuomotor rotations between 90° and 135° result in peak performance decrements. Research by Ames and colleagues failed to replicate Cunningham’s results in the laparoscopic environment, possibly due to (a) confounds from carryover effects or (b) use of an alternative laparoscopic training task rather than the straight-line pointing task used by Cunningham. Two experiments were conducted to determine if Cunningham’s results generalize to the laparoscopic environment when controlling for carryover effects for a three-dimensional “straight-line” pointing task (Experiment 1) and a laparoscopic training task (Experiment 2). Method: In Experiments 1 and 2, participants were assigned to one of five visuomotor rotations: 0°, 45°, 90°, 135°, or 180°. Utilizing a laparoscopic simulator, participants performed either a three-dimensional pointing task (Experiment 1) or a peg transfer task (Experiment 2). Results: In both experiments, visuomotor rotations of 90° or 135° resulted in the poorest performance. Conclusion: When controlling for carryover effects, Cunningham’s results generalize to novices’ performance of a pointing and a peg transfer task in the laparoscopic environment. Applications: The results indicate that 90° and 135° sideways laparoscope placements may result in worse performance for novices in the laparoscopic environment, indicating potentially longer learning curves for these conditions in the laparoscopic as well as other teleoperation environments.

The comprehensive assessment of middle school student bonding is important for basic research and to evaluate interventions. In this study, the psychometric properties of three assessment tools found in the literature were examined individually and then combined to create a shorter survey. With minor modifications, the tools were found to be psychometrically sound; however, they were burdensome in length and contained redundancy. This motivated the development of a shorter tool that was included in a cyclical process of multiple samples of students ( n = 53, 1,911, 2,050) in three phases. The cyclical process involved combining the three surveys, eliminating redundancy, and then examining the psychometric properties of the reduced survey. A final forth phase of the study resulted in a brief but comprehensive survey, Brief Survey of School Bonding. It was found to be psychometrically sound and appropriate for use with children 10 to 15 years of age.

Repetitive behavior is a hallmark feature of autism spectrum disorders (ASD), and can have adverse consequences related to social stigma and low rates of skill acquisition. Basic research suggests that variability, or the extent to which one response differs from previous responses, is amenable to antecedent and consequence manipulations. This article describes the concept of variability, synthesizes the findings of 14 recent studies on interventions to increase the variability of behavior in individuals with ASD, and proposes preliminary guidelines for practitioners that focus on building response repertoires, implementing contingencies to produce and maintain variability, and incorporating prompts to vary responding.

The Delaware Project, initiated in a conference at the University of Delaware, aims to redefine psychological clinical science training in ways that emphasize continuity across a spectrum of intervention development activities ranging from basic research to implementation and dissemination. The project generated specific recommendations for elevating dissemination and implementation, both at different stages of clinical science training and in different training settings, and highlighted several experiential training innovations to foster this goal. The project also helped sharpen competing priorities of two broad approaches to intervention science: one emphasizing translation, or moving from basic research to systematic applications in practice, and the other privileging dissemination–implementation per se, where a priority is understanding and maximizing the accessibility, acceptability, adaptability, and sustainability of interventions in the contexts where practitioners deliver them. The training of future clinical scientists will be crucial to reconciling these perspectives on how best to address significant public health problems.

Animal models of human disease are a critical tool in both basic research and drug development. The results of preclinical efficacy studies often inform progression of therapeutic candidates through the drug development pipeline; however, the extent to which results in inflammatory bowel disease (IBD) models predict human drug response is an ongoing concern. This review discusses how murine models are currently being used in IBD research. We focus on the considerations and caveats for commonly used models in preclinical efficacy studies and discuss the value of models that utilize specific pathogenic pathways of interest rather than model all aspects of human disease.

Scientific opportunities have never been better than today! The completion of the Human Genome project has sparked hope and optimism that cures for debilitating conditions can be achieved and tailored to individuals and communities. The availability of reference genome sequences and genetic variations as well as more precise correlations between genotype and phenotype have facilitated the progress made in finding solutions to clinical problems. While certain craniofacial and oral diseases previously deemed too difficult to tackle have benefited from basic science and technological advances over the past decade, there remains a critical need to translate the fruits of several decades’ worth of basic and clinical research into tangible therapies that can benefit patients. The fifth Annual Fall Focused Symposium, “Translational Genetics – Advancing Fronts for Craniofacial Health”, was created by the American Association for Dental Research (AADR) to foster its mission to advance interdisciplinary research that is directed toward improving oral health. The symposium showcased progress made in identifying molecular targets that are potential therapeutics for common and rare dental diseases and craniofacial disorders. Speakers focused on translational and clinical applications of their research and, where applicable, on strategies for new technologies and therapeutics. The critical needs to transfer new knowledge to the classroom and for further investment in the field were also emphasized. The symposium underscored the importance of basic research, chairside clinical observations, and population-based studies in driving the new translational connections needed for the development of cures for the most common and devastating diseases involving the craniofacial complex.

This article analyzes the evolution of the entrepreneurial university from a narrow focus on capturing the commercializable results of the ‘meandering stream of basic research’ to a broader interest in firm formation and regional economic development. No longer limited to schools like MIT, specialized for that purpose, entrepreneurial aspirations have spread to the academic mainstream. Academic involvement in (1) technology transfer, (2) firm formation and (3) regional development signifies the transition from a research to an entrepreneurial university as the academic ideal. As universities become entrepreneurial, tension arises between this new role and that of teaching and research as it has between research and teaching. Nevertheless, the university coheres as each of these new missions has fed back into and enhanced previous tasks.

Fiber-reinforced plastics (FRPs) with adaptive properties make lightweight structures feasible that not only possess a high mechanical force absorption but are also able to adapt their mechanical characteristics, such as geometry and rigidity, to external influences. Within the framework of the basic research presented here, new adaptive FRPs are developed on a basis of textile reinforcement semi-finished products integrated with actuators made from shape-memory alloys (SMAs). The realization of adaptive FRPs requires not only knowledge of the material-specific actuatory properties of the functional materials. It also necessitates the development of textile-technical solutions fully exploiting the actuatory potential of the SMAs within the composite. Promising approaches are hybrid yarn structures based on friction spinning technology. In order to reduce the great experimental effort, modeling and simulation of the SMA's material behavior and of the adaptive FRPs' complex composite behavior are carried out by means of finite element methods. It is shown that the developed actuators generate sufficiently high tensions of about 700–800 N/mm2, to bend the FRP specimen up to 45°.

The purpose of this article is to identify how Bowen family systems theory may be incorporated into individual counseling with adolescents when family involvement is not possible or contraindicated. Outcome and basic research supporting the application of Bowen family systems theory is reviewed. Specific clinical interventions for counseling adolescents that derive from Bowen family systems theory are provided, and a case study demonstrating these clinical interventions is presented.

Laparoscopic surgery requires surgeons to view rotated visual feedback of the surgical field. However, systematic assessments of the effects of visuomotor rotations on performance have been controversial. Forty novice undergraduates performed a pointing task in a laparoscopic trainer box while experiencing one of five different visuomotor rotations: 0°, 45°, 90°, 135°, and 180°. Performance was measured using root mean squared error (RMSE). When initially exposed to the visuomotor rotations, participants’ performance was superior in the 0° condition when compared to the 45°, 90°, and 135° conditions. The pattern of results observed in the present study were consistent with basic research by Cunningham (1989) that showed the most severe performance decrements for rotations between 90° and 135°. With prolonged exposure to the visuomotor rotations, participants adapted to the distortions. The results of the present study are relevant to the design of laparoscopic training currilicula.

Cognitive interviewing is a well-established method for evaluating and improving a questionnaire prior to fielding. However, its present implementation brings with it some challenges, notably in terms of small sample sizes or the possibility of interviewer effects. In this study, the authors test web surveys through nonprobability online panels as a supplemental means to implement cognitive interviewing techniques. The overall goal is to tackle the above-mentioned challenges. The focus in this article is on methodological features that pave the way for an eventual successful implementation of category-selection probing in web surveys. The study reports on the results of 1,023 respondents from Germany. In order to identify implementation features that lead to a high number of meaningful answers, the authors explore the effects of (1) different panels, (2) different probing variants, and (3) different numbers of preceding probes on answer quality. The overall results suggest that category-selection probing can indeed be implemented in web surveys. Using data from two panels - a community panel where members can actively get involved, for example, by creating their own polls, and a "conventional" panel where answering surveys is the members' only activity - the authors find that high community involvement does not increase the likelihood to answer probes or produce longer statements. Testing three probing variants that differ in wording and provided context, the authors find that presenting the context of the probe (i.e., the probed item and the respondent's answer) produces a higher number of meaningful answers. Finally, the likelihood to answer a probe decreases with the number of preceding probes. However, the word count of those who eventually answer the probes slightly increases with an increasing number of probes. (author's abstract)

This paper focuses on the process of coalition formation in presidential systems. It shows that party positions and institutions influence the formation of government coalitions. We argue that presidents will tend to include parties positioned close to their policy positions in their cabinets, and will be more inclined to do it when relative institutional authority is more advantageous to congress. We corroborate our arguments with data from 13 presidential countries in the Americas., Este artículo se centra en el proceso de formación de coaliciones en sistemas presidenciales. El artículo demuestra que las posiciones de los partidos y las instituciones influencian la formación de coaliciones gubernamentales. Argumentamos que los presidentes tienden a incluir dentro del gabinete a aquellos partidos que tienen posiciones cercanas, y que esta tendencia es más fuerte cuando la autoridad institucional es relativamente más favorable al congreso. Corroboramos nuestros argumentos con data de 13 países con sistemas presidenciales en las Américas.

Research technology organizations (RTOs) are undergoing a transition in their traditional role. This transition is driven by two key shifts in the environment within which RTOs operate: increasing pressure to commercialise research outputs and the internationalisation of the research endeavor, providing new opportunities for both funding and transfer of outputs. We note that these trends are felt in both industrialised and industrialising economies, acknowledging a need for properly framed comparative studies. Among the key questions addressed here: How do open, global R&D networks affect RTO research portfolios? Does building national resources reduce international opportunities? Can Asian RTOs reorient their operations from doing basic research to producing commercialisable outputs as effectively as some of their European counterparts? Before reviewing important developments in the RTO literature, we distinguish several types of RTOs. The literature reflecting the abovementioned environmental shifts indicates that RTOs play an important role in helping industrialising economies catch up with their industrialised counterparts. We note also the role RTOs play in transferring university research outputs, and call for more studies of the role of RTOs in industrialization as opposed to agricultural development. We close with brief descriptions of the five studies that comprise this special issue.

Research has established that research and development (R&D)-intensive firms are characterized by substantial future risk-adjusted stock returns. The reasons for this phenomenon and its policy implications, however, are widely debated. Some attribute the excess returns to investors' systematic undervaluation of R&D firms and argue for improved disclosure to mitigate the mispricing. whereas others claim that the excess returns are just compensating for an R&D-speciftc risk factor We aim to provide insights into this controversy by examining R&D firms with substantial R&D outlays, that is, firms with R&D as an important ingredient in their strategy. Among such firms, we compare firms with high and low industry-adjusted R&D intensity. The high industry-adjusted R&D intensity firms are more likely to engage in basic research activities, whereas the low Indus try-adjusted R&D intensity firms are likely to mimic and extend existing technologies. As such, compared with the low industry-adjusted R&D intensity firms, the high industry-adjusted R&D intensity firms are likely to suffer from higher information asymmetry. We find that high industry-adjusted R&D intensity firms generate larger risk-adjusted returns compared with low industry-adjusted R&D intensity firms in the first five future years, after which the excess returns for the high group converge to those of the low group in the long run. This reversal in returns is consistent with undervaluation of high industry-adjusted R&D intensity firms. The long-term excess returns are positive for both the high and the low industry-adjusted R&D intensity firms, and these excess returns are partly attributable to information risk. We also show that the future excess returns of high industry-adjusted R&D intensity firms are lower for those firms who provide voluntary disclosure (earnings guidance) suggesting that the short-term undervaluation is likely due to mispricing.

The migratory or proliferative responses mounted by wounded cell monolayers are important to drug discovery and drug safety testing, as well as to basic research across a number of disciplines, including stem-cell biology, cell biology, ophthalmology, endocrinology, microbiology, oncology, and developmental biology. Scratch wounding by mechanical means is the golden standard to achieve an appropriate model system in which to study these cellular reactions. The scratch wounding technique is plagued by wound size irregularity, release of cytosolic contents along the wound edge, and difficulty in scaling up to higher throughput screening. To address these issues, we developed a microfluidic device coupled to a well plate in which wounds were produced enzymatically using highly controlled laminar flow streams. Within the device, epithelial cells were cultivated and exposed to different compounds. Proliferation and migration were characterized by bright-field microscopy. Resulting wound size was highly uniform compared with reported variability of manual scratch wounding. The protocol for wounding was fully automated using customized software, and response to wounding was followed in real time by microscopy.

Introduction: Eccentric (negative) resistance exercise of the legs using specialized machines has been reported to be useful and often superior to standard exercise following total knee arthroplasty (TKA). Movements that utilize body mass and gravity as a mode of eccentric resistance exercise in a more pragmatic rehabilitation paradigm may also be useful in reversing chronic muscle impairments observed years following surgery. This study explores whether an eccentrically biased, body mass resistance exercise induces greater magnitude of sagittal plane extensor angular impulse of the support torque and individual net joint torque contributions during both squatting and lunging movement patterns 6 weeks following TKA. Methods: Cross-sectional laboratory-based study design including 10 patients following primary unilateral TKA (6.5 ± 0.8 weeks.). All patients completed 3 trials of the squat and lunge movement pattern under both a concentric and an eccentric condition. Extensor angular impulse of the support torque and net joint torque contributions were calculated by integrating the joint torque versus time curves. A Two-way analysis of covariance was conducted and contracts of clinical interest were computed using Wald posttest. P Values for all pairwise comparisons were adjusted for multiplicity using Bonferroni multiple comparison procedure. Results: The eccentric condition, compared to the concentric condition, displayed larger magnitude of extensor angular impulse during both the squat ( P < .001) and lunge ( P < .001) movement patterns for the support torques. Similarly, the eccentric condition, compared to the concentric condition, displayed larger magnitude of extensor angular impulse of the hip, knee, and ankle ( P < .001) during both movement patterns. Conclusion: Eccentrically biased, body mass movement exercises can produce higher levels of extensor angular impulse on the surgical limb in patients early after TKA. Patients in this study were able to tolerate the higher extensor angular impulse demands and performed the eccentrically biased conditions (without specialized machines) that could be beneficial in postoperative rehabilitation.

This study examines administrative protocols established by a ground‐level subunit in a complex organization during a 13‐year period. The protocols are identifiable, verifiable, and (for the questions examined in this study) objectively interpretable. The authors report tangible evidence that the subunit developed some of its own emergent organizational characteristics, consistent with predictions using a loose coupling model. Copresent, however, clear manifestations are also found of the subunit at certain times merely acting out unitary executive–style policy decisions that have been made at higher administrative levels in the organization.

The teaching of quantitative research methods is an integral part of most postgraduate programmes in politics, but less common at undergraduate level. This article explores the extent to which research methods in general, and quantitative research methods in particular, form part of the curricula of Politics departments in the UK. We then discuss an approach for motivating interest in a subject that tends to be unpopular with many students. We recommend an approach that utilises the links between the general quantification of politics with the quantitative study of political phenomena, as well as a combination of basic research methods for all and more advanced student-focused training for some.

The applicability of basic research in psychological science is obvious to those in the field, but too often underappreciated outside of it. In this article, I suggest some reasons for that gap, including confusion between the relevance of psychological science and its actual application, which can lead to hype; the interdisciplinary nature of applied science, which can obscure the credit due to the field; and the considerable difficulty of moving basic research into application, including the potential for resistance to the products we deliver. I suggest that our own students constitute a relatively underutilized audience for demonstrating that psychological science has been critical to applications, and I describe an applied cognitive science course that is intended to make the case to them.

In the framework of the National Key Basic Research Program (973 Program) we focus our attention on research and development of (1) continuous enhancement of composites performance both for new generation and existing materials, (2) cost-effective manufacturing technologies, particularly resin transfer molding (RTM) in conjunction with textile technology, and (3) crashworthy composite structures in design, and manufacturing and simulation methodology for aircraft composites. Many successful example stories, such as ex situ concept, have demonstrated that the performance potential of composites could be enhanced and maximized by basically understanding the complicated multi-scale and multidimensional structural characteristics in relation to properties. Based on the concept, graphite composites system with generally high-impact damage resistance and balanced processing conditions has being developed consisting of base resins, modifiers, and binders/tackifiers.

Out-of-school youth are particularly vulnerable to HIV/AIDS due to factors of poverty, lack of employment opportunities, low self-esteem and entrenched notions of gender. Many HIV/AIDS information campaigns are run through schools and, even though high profile prevention campaigns are broadcast through the media, out-of-school youth are beyond the reach of a structured learning environment in which they can discuss and ask questions regarding the information they have received. We investigated not only their views on HIV/AIDS, love, sex and friendships, but also how out-of-school youth talk to each other about these topics and the discourses they utilise. We also asked where they obtain their information on HIV/AIDS and how they respond personally to the challenges of the disease in their communities. Eight out-of-school youths were trained in basic research skills to carry out interviews with 32 other out-of-school youth in the Lamontville and Shongweni Dam areas in KwaZulu-Natal, South Africa. The analysis of their conversations provides a starting point for informing intervention campaigns that address marginalised youth who exist “between the cracks” of HIV/AIDS education.