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Background:Psilocybin, a psychoactive serotonin receptor partial agonist, has been reported to acutely reduce clinical symptoms of depressive disorders. Psilocybin’s effects on cognitive function have not been widely or systematically studied.Aim:The aim of this study was to explore the safety of simultaneous administration of psilocybin to healthy participants in the largest randomised controlled trial of psilocybin to date. Primary and secondary endpoints assessed the short- and longer-term change in cognitive functioning, as assessed by a Cambridge Neuropsychological Test Automated Battery (CANTAB) Panel, and emotional processing scales. Safety was assessed via endpoints which included cognitive function, assessed by CANTAB global composite score, and treatment-emergent adverse event (TEAE) monitoring.Methods:In this phase 1, randomised, double-blind, placebo-controlled study, healthy participants ( n = 89; mean age 36.1 years; 41 females, 48 males) were randomised to receive a single oral dose of 10 or 25 mg psilocybin, or placebo, administered simultaneously to up to six participants, with one-to-one psychological support – each participant having an assigned, dedicated therapist available throughout the session.Results:In total, 511 TEAEs were reported, with a median duration of 1.0 day; 67% of all TEAEs started and resolved on the day of administration. There were no serious TEAEs, and none led to study withdrawal. There were no clinically relevant between-group differences in CANTAB global composite score, CANTAB cognitive domain scores, or emotional processing scale scores.Conclusions:These results indicate that 10 mg and 25 mg doses of psilocybin were generally well tolerated when given to up to six participants simultaneously and did not have any detrimental short- or long-term effects on cognitive functioning or emotional processing.Clinical Trial Registration:EudraCT ( https://www.clinicaltrialsregister.eu/ ) number: 2018-000978-30.

The present study examines the benefits of an in-person intergenerational contact program called SAGE (Successful Aging and Inter-Generational Experiences). The SAGE Program pairs older adults (M age 85 years) and younger adults (M age 23 years) for 2 to 3-hour weekly meetings over a 7-week period, where participants can share memories, skills, and values, and foster new perspectives and friendships. We expected the SAGE Program to benefit both older and younger participants with respect to identity processes, subjective well-being, positive mood, and wisdom while reducing ageist beliefs compared to old and young participants serving as their matched controls. Overall, participants in the SAGE Program reported greater identity synthesis,subjective well-being, and positive mood. Exploratory analyses suggested that identity synthesis is a likely mediator of that effect. The SAGE Program did not reduce ageist beliefs, but age differences in ageism were found. We address additional results,limitations, and future research directions.

The present study tested a prediction model involving affectivity and dispositional optimism as predictors of suicide risk (i.e., depressive symptoms and suicidal ideation) in young adult Chinese females with and without prior interpersonal violence (IPV) victimization (294 nonvictimized and 94 victimized females). Results of hierarchical regression analyses indicated that negative affectivity was a significant predictor of both depressive symptoms and suicidal ideation for Chinese females, regardless of IPV victimization. Beyond affectivity, dispositional optimism was found to further add to the prediction model of depressive symptoms in both groups, but only for suicidal ideation in the IPV victimized group.

The menopausal transition is associated with increasing sleep disorders including sleep apnoea and restless leg syndrome. Insomnia is the most common and is recognised as a core symptom of the menopause. Guidelines to support decision making for women with sleep problems during the menopausal transition are lacking. Sleep problems are associated with negative impacts on healthcare utilisation, quality of life and work productivity. Sleep deprivation is a risk factor for cardiovascular disease, diabetes, obesity and neurobehavioral dysfunction. Declining oestrogen is implicated as a cause of menopausal sleep disruption. Vasomotor symptoms (VMS) and menopausal mood disturbance are also factors in the complex aetiology. VMS commonly precipitate insomnia and, due to their prolonged duration, they often perpetuate the condition. Insomnia in the general population is most effectively treated with cognitive behavioural therapy (CBT) (also effective in the menopausal transition.) The associations of menopausal sleep disturbance with VMS and depression mean that other treatment options must be considered. Existing guidelines outline effectiveness of hormone replacement therapy (HRT), CBT and antidepressants. HRT may indirectly help with sleep disturbance by treating VMS and also via beneficial effect on mood symptoms. The evidence base underpinning menopausal insomnia often references risks associated with HRT that are not in line with current international menopause guidelines. This may influence clinicians managing sleep disorders, leading to hesitation in offering HRT, despite evidence of effectiveness. Viewing sleep symptoms on an axis of menopausal symptoms – towards vasomotor symptoms or towards mood symptoms may help tailor treatment options towards the symptom profile.

Background International evidence on the frequency of mood or anxiety disorders among migrant groups is highly variable, as it is dependent on the time since migration and the socio-political context of the host country. Our objective was to estimate trends in the prevalence of diagnosed mood or anxiety disorders among recent (Methods We used a repeated cross-sectional design consisting of four cross-sections spanning 5 years each, constructed using health administrative databases from 1995 to 2015. We included all Ontario residents between the ages of 16 and 64 years. We assessed differences in the prevalence of mood or anxiety disorders adjusting for age, sex, and neighbourhood-level income. We further evaluated the impact of migrant class and region of birth. Results The prevalence of mood or anxiety disorders was lower among recent (weighted mean = 4.10%; 95% confidence interval [CI], 3.59% to 4.60%) and settled (weighted mean = 4.77%; 95% CI, 3.94% to 5.61%) migrant groups, relative to the general population (weighted mean = 7.39%; 95% CI, 6.83% to 7.94%). Prevalence estimates varied greatly by region of birth and migrant class. We found variation in prevalence estimates over time, with refugee groups having the largest increases between 1995 and 2015. Conclusions Our findings highlight the complexity of mood and anxiety disorders among migrant groups, and that not all groups share the same risk profile. These results can be used to help inform health service allocation and the development of supportive programs for specific migrant groups.

Air pollution has become a daunting challenge with the potential to endanger people’s lives across the globe. However, little is known about the psychological and vocational implications of air pollution. Drawing on feeling-as-information theory, we investigate the within-person relationships of ambient air pollution with vocational and general well-being outcomes (i.e., career choice anxiety and state optimism) through the mediating mechanism of mood state. We tested our hypotheses using an experience sampling method (ESM) with survey data from 67 undergraduate students in South Korea collected over 10 consecutive days. Results showed that daily ambient air pollution predicted higher career choice anxiety and lower state optimism via an increased negative mood. Furthermore, the indirect relation of air pollution with career choice anxiety was found to be stronger for individuals with lower family socioeconomic status. In a supplementary study, we interviewed 16 undergraduate students in South Korea to explain the ESM results in greater depth. Theoretical and practical implications, as well as study limitations, are discussed.

Background: Depression and low mood are leading contributors to disability worldwide. Research indicates that clinical depression may be associated with low creatine concentrations in the brain and low prefrontal grey matter volume. Because subclinical depression also contributes to difficulties in day-to-day life, understanding the neural mechanisms of depressive symptoms in all individuals, even at a subclinical level, may aid public health. Methods: Eighty-four young adult participants completed the Depression, Anxiety and Stress Scale (DASS) to quantify severity of depression, anxiety and stress, and underwent 1H-Magnetic Resonance Spectroscopy of the medial prefrontal cortex and structural magnetic resonance imaging (MRI) to determine whole-brain grey matter volume. Results/outcomes: DASS depression scores were negatively associated (a) with concentrations of creatine (but not other metabolites) in the prefrontal cortex and (b) with grey matter volume in the right superior medial frontal gyrus. Medial prefrontal creatine concentrations and right superior medial frontal grey matter volume were positively correlated. DASS anxiety and DASS stress scores were not related to prefrontal metabolite concentrations or whole-brain grey matter volume. Conclusions/interpretations: This study provides preliminary evidence from a representative group of individuals who exhibit a range of depression levels that prefrontal creatine and grey matter volume are negatively associated with depression. While future research is needed to fully understand this relationship, these results provide support for previous findings, which indicate that increasing creatine concentrations in the prefrontal cortex may improve mood and well-being.

Group singing elevates mood, increases social bonding, and regulates stress. However, the question remains as to how much of the singer’s mood-boost is derived from social aspects of group singing and how much can be achieved through singing alone. In the current study, we adopted a sociobiological approach to investigate the underpinnings of the mood-boosting effect of singing. Using a within-subjects design, self-report mood, salivary oxytocin, and salivary cortisol were assessed before and after group and individual singing conditions. This study uncovered several important findings: group singing elevated mood, whereas individual singing did not. Importantly, although both group and individual singing led to decreases in cortisol, only group singing led to increases in oxytocin. Further analysis revealed that oxytocin, but not cortisol, significantly correlated with mood. These findings suggest that the mood-boosting effect of singing is likely due to social aspects and is influenced by changes in oxytocin.

The study investigates and confirms the spillover effects from investor fear, mood, sentiment and uncertainty to the US tourism sector returns. The findings indicate that market fear, investor mood and sentiment are net transmitter of shocks and economic uncertainty and the tourism sector is net receiver of shocks. We also provide evidence that media-hype, infodemic, media-coverage related to COVID-19 and infectious disease equity market volatility impacts the total and directional spillover of information from fear, mood, sentiment and uncertainty to the tourism sector.

Our pilot study explored the effects of a new, five-session group keyboard music-making protocol on the mood states of non-musician college students. Twenty-five math and engineering students participated in a keyboard music-making program without the expectation or need for extensive technical preparation or regular music practice. To assess changes in mood states before and after music-making activities, we administered the Profile of Mood States-Short Form (POMS-SF) questionnaire. Here, we show significant and lasting improvements in participant’s negative and positive mood states, which were more robust than mood improvements reported with other Recreational Music Making (RMM) protocols, suggesting a strong therapeutic potential of our group keyboard music-making program.

Background: Peripartum depression (PPD) is underexplored in multiple sclerosis (MS). Objective: To evaluate prevalence of and risk factors for PPD in women with MS. Methods: Retrospective single-center analysis of women with MS with a live birth. Prevalence of PPD was estimated with logistic regression with generalized estimating equations (GEE). GEE evaluated predictors of PPD (e.g. age, marital status, parity, pre-pregnancy depression/anxiety, antidepressant discontinuation, sleep disturbance, breastfeeding, relapses, gadolinium-enhancing lesions, and disability). Factors significant in univariable analyses were included in multivariable analysis. Results: We identified 143 live births in 111 women (mean age 33.1 ± 4.7 years). PPD was found in 18/143 pregnancies (12.6%, 95% CI = 7.3–17.8). Factors associated with PPD included older age (OR 1.16, 95% CI = 1.03–1.32 for 1-year increase), primiparity (OR 4.02, CI = 1.14–14.23), pre-pregnancy depression (OR 3.70, CI = 1.27–10.01), sleep disturbance (OR 3.23, CI = 1.17–8.91), and breastfeeding difficulty (OR 3.58, CI = 1.27–10.08). Maternal age (OR 1.17, CI = 1.02–1.34), primiparity (OR 8.10, CI = 1.38–47.40), and pre-pregnancy depression (OR 3.89, CI = 1.04–14.60) remained significant in multivariable analyses. Relapses, MRI activity, and disability were not associated with PPD. Conclusion: The prevalence of PPD in MS appeared similar to the general population, but was likely underestimated due to lack of screening. PPD can affect MS self-management and offspring development, and prospective studies are needed.

The shared mood or affect of a work group can exert a powerful influence on the group’s social dynamics and effectiveness. However, the mood of others can be difficult to read, leading to divergent perceptions of group affect among members. What happens when individuals perceive the group’s affect differently? We answer this question by investigating how divergence in perceptions of group affect influences individuals’ social integration and the group’s performance. In doing so, we examine the implications of divergence in perceived group affect for individuals and the group as a whole. In a field study of 1419 individuals in 107 work groups, we found that divergence in perceptions of the group’s positive affect was negatively associated with individuals’ commitment to the team and undermined the positive impact of group affect on group performance. We discuss the implications of our findings for refining theory on group affect, the value of strongly shared affect, and how leaders can foster a stronger sense of shared affect within groups.

The role of music in second-language (L2) learning has long been the object of various empirical and theoretical inquiries. However, research on whether the effect of background music (BM) on language-related task performance is facilitative or inhibitory has produced inconsistent findings. Hence, we investigated the effect of happy and sad BM on complexity, accuracy, and fluency (CAF) of L2 speaking among intermediate learners of English. A between-groups design was used, in which 60 participants were randomly assigned to three groups with two experimental groups performing an oral L2 English retelling task while listening to either happy or sad BM, and a control group performing the task with no background music. The results demonstrated the happy BM group’s significant outperformance in fluency over the control group. In accuracy, the happy BM group also outdid the controls (error-free clauses, correct verb forms). Moreover, the sad BM group performed better in accuracy than the controls but in only one of its measures (correct verb forms). Furthermore, no significant difference between the groups in syntactic complexity was observed. The study, in line with the current literature on BM effects, suggests that it might have specific impacts on L2 oral production, explained by factors such as mood, arousal, neural mechanism, and the target task’s properties.

Mindfulness is an ancient practice, derived from Buddhism and recently adapted for the treatment of depression and other psychological conditions. The mechanism of action is thought to involve the extinction of habitual or conditioned responses to internal cognitive and emotional content. In turn, this relies on mechanisms of attentional control and emotion regulation. The resulting state of consciousness is sometimes described as equanimity. This conceptual review paper explores the process of achieving equanimity within a homeostatic framework. The result is a model of moodfulness, which combines mindfulness with Homeostatically Protected Mood to provide a new theoretical view of recovery from symptoms of depression. This model presents a case for mindfulness restoration of mood homeostasis following homeostatic defeat.

Objective: Neurocognitive impairment is considered a core feature of mood disorders. Research has shown that neurocognitive impairment often persists beyond mood symptom resolution and can have significant deleterious effects on interpersonal relationships, academic achievement, occupational functioning and independent living. As such, neurocognitive impairment has become an important target for intervention. In this systematic review, we aimed to examine the extant literature to ascertain whether current standard evidence-based psychotherapies can improve neurocognitive functioning in mood disorders. Method: Studies examining changes in neurocognitive functioning following evidence-based psychotherapy were identified using MEDLINE, PsycINFO and Web of Science databases. Given the heterogeneity of study procedures, treatment protocols and patient samples, a narrative rather than meta-analytic review technique was employed. Results: Nineteen studies (21 articles) met inclusion criteria. There was preliminary evidence of improved executive functioning following evidence-based psychotherapy for Major Depressive Disorder and Bipolar Disorder. There was also some signal of reduced negative biases in emotional information processing following psychotherapy in depression. Due to methodological variability across studies however, it was difficult to draw clear conclusions. Conclusion: Findings from the current review suggest that evidence-based psychotherapies may influence some aspects of neurocognitive functioning in mood disorders. This continues to be an ongoing area of importance and warrants further research.

Background. Stroke survivors commonly complain of difficulty sleeping. Poor sleep is associated with reduced quality of life and more understanding of long-term consequences of stroke on sleep is needed. Objective. The primary aims were to (1) compare sleep measures between chronic stroke survivors and healthy controls and (2) test for a relationship between motor impairment, time since stroke and sleep. Secondary aims were to explore mood and inactivity as potential correlates of sleep and test the correlation between self-reported and objective sleep measures. Methods. Cross-sectional sleep measures were obtained for 69 chronic stroke survivors (mean 65 months post-stroke, 63 years old, 24 female) and 63 healthy controls (mean 61 years old, 27 female). Self-reported sleep was assessed with the sleep condition indicator (SCI) and sleep diary ratings, objective sleep with 7-nights actigraphy and mood with the Hospital Anxiety and Depression Scale. Upper extremity motor impairment was assessed with the Fugl-Meyer assessment. Results. Stroke survivors had significantly poorer SCI score ( P < .001) and higher wake after sleep onset ( P = .005) than controls. Neither motor impairment, nor time since stroke, explained significant variance in sleep measures for the stroke group. For all participants together, greater depression was associated with poorer SCI score ( R2adj = .197, P < .001) and higher age with more fragmented sleep ( R2adj = .108, P < .001). There were weak correlations between nightly sleep ratings and actigraphy sleep measures ( r s = .15–.24). Conclusions. Sleep disturbance is present long-term after stroke. Depressive symptoms may present a modifiable factor which should be investigated alongside techniques to improve sleep in this population.

Traditionally, various Hindustani (North Indian) ragas have been performed at specific times of day, such as dawn, dusk, midday, and evening. Human physiology also exhibits common circadian patterns, with reduced arousal at night, rising during the morning, culminating in peak arousal, and then declining arousal towards the end of the day. This raises the question of how and whether the musical features of ragas for each time of day are related to these circadian patterns of arousal. We formally examined associations between traditionally designated time-of-day classifications and musical features from 65 Hindustani raga performances. Our results showed that only pitch-related features are predictive of time-of-day classifications. Surprisingly, non-pitch factors known to correlate with arousal, such as tempo, did not covary with raga time-of-day practices. In general, the results are consistent with rules for North Indian raga performances described by Vishnu Narayan Bhatkhande (1860–1936) that emphasize the presence or prevalence of particular tones in the raga. The results point to a combination of enculturated and embodied influences in conveying musical arousal. Specifically, they suggest that while time-of-day-related raga listening practices may have been initially influenced by embodied processes, they have ultimately been reshaped by pitch-related cultural norms.

Purpose: The purpose of this study was to evaluate the psychological distress of urological and uro-oncological patients undergoing surgery. Methods: Patients who presented to Mercy University Hospital from October 2019–May 2020 were consecutively recruited. Demographic and clinical characteristics including age, gender, marital status, type of surgery (uro-oncology or general urology), endoscopy or open surgery were gathered. Mood was evaluated using the Hospital Anxiety and Depression Scale prior to admission, prior to discharge and 6 weeks post-surgery. Results: A total of 118 participants (79.7% male) completed the Hospital Anxiety and Depression Scale prior to admission, prior to discharge and at 6 weeks post-surgery. Forty patients (33.9%) underwent uro-oncology-related surgery. At pre-admission 39 patients (33%) fell into a possible-probable clinical category for anxiety and 15 (12.7%) for depression. Older patients had significantly lower anxiety levels than younger patients ( p⩽0.01). There were no differences between patients undergoing uro-oncology or more general urology surgery and levels of anxiety or depression. Repeated measures analysis of variance with age as a covariate indicated no significant differences in Hospital Anxiety and Depression Scale anxiety scores over time. There was a statistically significant reduction in Hospital Anxiety and Depression Scale depression scores over the three assessment time points ( p=0.004). Conclusion: Over one-third of patients were experiencing moderate to severe levels of psychological distress pre-surgery – higher than levels previously reported in uro-oncological patients. Surprisingly, there was no difference in anxiety and depression scores in uro-oncology and urology patients. Psychological distress in both uro-oncology and more general urology patients should be considered in the surgical setting. Level of evidence Moderate

Research on compulsive use of smartphones amongst students largely remains unexplored. The study seeks to investigate the feasibility and desirability motives—instant gratification, mood regulations, convenience, flow and personality—to understand the compulsive use of smartphones. The results of the useful data of 200 respondents following purposive sampling design, provided evidence of instant gratification, mood regulation and convenience motives, which significantly explain flow and compulsive smartphone use. Personality of users also appeared as a significant moderator between flow and compulsive smartphone use. The findings of the study reveal that the personality of smartphone users enhances the propensity to build compulsive smartphone use. Additionally, the findings reveal the double-edged sword impact of flow in forming compulsive smartphone use and allowing smartphone brands to design phones that help phone users to develop self-control over their behaviours related to using smartphones.

Introduction The transition from childhood to adolescence and from adolescence to adulthood are vulnerable phases in life. In these phases, late or insufficient treatment of diseases may lead to chronification and favor development of additional disorders. In adolescents, migraine often has a highly negative impact on school performance and everyday life. The hypothesis of the present study was that adolescents with migraine have a higher risk for developing additional disorders such as psychiatric disorders or other pain syndromes in the course of the disease. Materials and methods In this study, we analyzed health insurance data of 56,597 German adolescents at the age of 15 years in the year 2006. By using the International Classification of Diseases (ICD 10), we determined a group with migraine diagnosis in the year 2006 and a control group without any headache diagnosis in 2006. We then compared both groups regarding the development of additional disorders (based on the ICD 10) during the following 10 years (2007 to 2016). Results Adolescents with migraine had a 2.1 fold higher risk than persons without migraine diagnosis to develop an additional affective or mood disorder, a 1.8 fold higher risk to obtain neurotic, stress-related and somatoform disorders, a 1.8 fold higher risk to subsequently suffer from behavioral syndromes, a 1.6 higher risk to get back pain and a 1.5 fold higher risk for irritable bowel syndrome during the next 10 years. Conclusion Adolescents with migraine are at risk for developing additional disorders later. Considering and addressing the patient’s risks and potential medical and psychosocial problems might improve the long-term outcome significantly.

This study explored associations among test anxiety, GPA, sleep quality, and mood in college students. Data were collected from undergraduate students ( N = 316). Results revealed that higher levels of test anxiety and sleep impairment predicted negative mood in undergraduates. Findings suggest that prioritizing sleep could help improve overall mood among students with test anxiety. Future studies should work toward clarifying the complex and reciprocal relationship between sleep and test anxiety.

Making negative inferences for negative events, ruminating about them, and retrieving negative aspects of memories have all been associated with depression. However, the causal mechanisms that link negative inferences to negative mood and the interplay between inferences, rumination, and memory have not been explored. In the current study, we used a cognitive-bias modification (CBM) procedure to train causal inferences and assessed training effects on ruminative thinking, memory, and negative mood among people with varying levels of depression. Training had immediate effects on negative mood and rumination but not after recall of a negative autobiographical memory. Note that training affected memory: Participants falsely recalled inferences presented during the training in a training-congruent manner. Moreover, among participants with high levels of depression, training also affected causal inferences they made for an autobiographical memory retrieved after training. Our findings shed light on negative cognitive cycles that may contribute to depression.

Aim: During the last several decades, researchers have produced abundant evidence of the environmental impacts on stress, attention, and physical activity. More recently, scholars have turned their focus to the influence environments have on mental wellness. Therefore, a critical review of this more recent research is both timely and crucial for setting the future research agenda. Methods: In this article, we examined 65 papers published between 2008 and 2019 that examined the environmental correlates of a wide variety of mental health outcomes. We coded each study by type of environment, research design, mental health measurement scale used, and p-value. Results: We categorized the research studies into six groups based on mental health outcomes: emotions, moods, vitality, executive function, stress, and general well-being. Our review revealed several trends among the studies, including a heavy focus on nature and outdoor environments with little attention to workplace or residential environments; a lack of consensus on how to operationalize the environment; a heavy reliance on self-reported ratings using a wide variety of scales, many focused on the same outcome; and a disproportionate focus on short-term health effects. Conclusions: There is a need for greater consensus on research constructs and health outcome measurements, focused on a wider variety of environmental settings and scales, in order to better inform evidence-based environmental design practice.

Alexithymia, fear of intimacy, attachment security, and mood variables were examined as predictors of satisfaction in couple relationships after accounting for age, sex, relationship length, and marital status. Participants were 158 adults (52% women and 48% men) in an ongoing couple relationship for 1-19 years. They completed validated measures of the variables of interest online. Bivariate correlations were significant for all predicted associations. Multiple mediation modelling examined the hypothesis that the low relationship satisfaction reported by those with alexithymia can be explained by fear of intimacy, insecure attachment, and negative affect, after accounting for relevant covariates. Mediation was indicated for fear of intimacy and negative affect. Such factors may merit particular attention by clinicians working with alexithymic clients in couples therapy.

Objectives: Exposure to nature or to green space has positive mental health benefits. Closing of parks and green spaces during the COVID-19 pandemic has reduced options for mental health and well-being benefits and could have a greater impact on vulnerable populations, especially the elderly. The present study, therefore, explores the physiopsychological impacts of indirect contact with nature, using forest imagery, on the brain activity and autonomic nervous systems of elderly people. Study Design: A within-subject design experiment was used. Methods: Thirty-four participants aged 82.9 ± 0.78 years were asked to look at bamboo and urban images for 2 min. During the visual stimulation, α relative waves were measured using electroencephalography as an indicator of brain activity. Heart rate variability and skin conductance (SC) responses were utilized as indicators of arousal. Afterward, psychological responses were evaluated using the semantic differential and the Profile of Mood States questionnaires. Results: Visual stimulation with bamboo image induced a significant increase in α relative waves and parasympathetic nervous activity and a significant decrease in SC. In addition, a significant increase in perceptions of “comfortable,” “relaxed,” “cheerful,” and “vigorous” feelings was observed. Conclusions: Indirect contact with nature enhances the physiological and psychological conditions of the elderly. Findings can be used to guide the new design, renewal, and modification of the living environments of the elderly and those who are unable to get outside.

The article presents the development and validation of the instrumental practice–related affect measure (IPAM), based on the circumplex model of affect. This 16-item measure assesses four types of affect related to practicing a musical instrument: anxiety, comfort, depression, and enthusiasm. We conducted two studies. Confirmatory factor analysis supports the measure’s four-factor structure, allowing also for the distinction of two higher-order factors: positive and negative affect. The IPAM scales are highly reliable and correlate with affective traits, confirming the validity of the measure. The IPAM allows for capturing affective experiences in the musical learning context, in both basic and applied research.

There is consistent evidence from cross-sectional studies that smoking is positively associated with mental disorders. The research on the prospective association, however, is inconsistent. In the present study, we aimed to further increase the knowledge of this association by addressing several issues in the body of research. Data used were from a nationally representative, population-based cohort study among 18- to 64-year-olds at baseline. Compared with nonsmokers, smokers at baseline were significantly more likely to experience first incidence of any mood, anxiety, or substance use disorder at 3-year follow-up while controlling for a wide range of confounding factors. The association with incident mood and anxiety disorders was particularly high among heavy smokers. The dose-effect analyses on later substance use disorders showed unclear results, warranting further research. Additional analyses showed that results at 6-year follow-up were very similar, except for a weaker relationship between smoking and substance use disorders.

The involvement of top-down processes in perception and cognition is widely acknowledged by now. In fields of research from predictions to inhibition, and from attentional guidance to affect, a great deal has already been charted. Integrating this newer understanding with accumulated findings from the past has made it clear that human experience is determined by a combination of both bottom-up and top-down processes. It has been proposed that the ongoing balance between their relative contribution affects a person’s entire state of mind, an overarching framework that encompasses the breadth of mental activity. According to this proposal, state of mind, in which multiple facets of mind are clumped together functionally and dynamically, orients us to the optimal state for the given circumstances. These ideas are examined here by connecting a broad array of domains in which the balance between top-down and bottom-up processes is apparent. These domains range from object recognition to contextual associations, from pattern of thought to tolerance for uncertainty, and from the default-mode network to mood. From this synthesis emerge numerous hypotheses, implications, and directions for future research in cognitive psychology, psychiatry, and neuroscience.

Background Research suggests there is a lack of post-diagnostic support to enable people living with dementia to fulfil social and active lives throughout their dementia journey. Gardening has been found to have many benefits for people living with dementia. Although such research is important, most research frames people with dementia as passive recipients of stimulation. Research into the impact of a community-based gardening group, where people living with dementia are active in the development of an outdoor space, is underdeveloped. Knowledge about the impact of participating in such groups is also sparse. The Good Life Club (GLC) was co-developed and evaluated to respond to these gaps. Objectives The primary aim of this article is to present the findings regarding the impact of attending the GLC on the self-reported well-being for people living with dementia and care partners. Methods Qualitative data were collected via 22 semi-structured interviews. Fourteen interviews were conducted before the GLC and eight after the GLC. Thematic analysis was used to analyse data. Dementia Care Mapping data were collected to supplement the interview data. Findings Four key themes were identified. The first was that participants considered having active participation in social life to be a key aspect of living a good life. The second was that the way that the GLC was set up and delivered gave the participants ownership of the GLC and within this they felt able to contribute. The third was the importance of social connectedness and peer support to the well-being of both people living with dementia and care partners. Fourth, positive mood and well-being was directly experienced through gardening. Conclusions The combination of long-term investment of time and energy to the GLC, ongoing friendships and in-session autonomy act as key ingredients in creating a group that is relaxed, full of humour and highly valued.

Objective: To determine the feasibility and acceptability of peer-befriending, for people with aphasia. Design: Single-blind, parallel-group feasibility randomised controlled trial comparing usual care to usual care + peer-befriending. Participants and setting: People with aphasia post-stroke and low levels of distress, recruited from 5 NHS Hospitals and linked community services; their significant others; and 10 befrienders recruited from community. Intervention: Six 1-hour peer-befriending visits over three months. Main measures: Feasibility parameters included proportion eligible of those screened; proportion consented; missing data; consent and attrition rates. Acceptability was explored through qualitative interviews. Outcomes for participants and significant others were measured at baseline, 4- and 10-months; for peer-befrienders before training and after one/two cycles of befriending. Results: Of 738 patients identified, 75 were eligible of 89 fully screened (84%), 62 consented (83% of eligible) and 56 randomised. Attrition was 16%. Adherence was high (93% attended ⩾2 sessions, 81% all six). The difference at 10 months on the GHQ-12 was 1.23 points on average lower/better in the intervention arm (95% CI 0.17, −2.63). There was an 88% decrease in the odds of GHQ-12 caseness (95% CI 0.01, 1.01). Fourty-eight significant others and 10 peer-befrienders took part. Procedures and outcome measures were acceptable. Serious adverse events were few ( n = 10, none for significant others and peer-befrienders) and unrelated. Conclusions: SUPERB peer-befriending for people with aphasia post-stroke experiencing low levels of distress was feasible. There was preliminary evidence of benefit in terms of depression. Peer-befriending is a suitable intervention to explore further in a definitive trial. Clinical trial registration-URL: http://www.clinicaltrials.gov Unique identifier: NCT02947776 Subject terms: Translational research, mental health, rehabilitation, quality and outcomes, stroke

Major depressive disorder (MDD or depression) is a debilitating neuropsychiatric syndrome with genetic, epigenetic, and environmental contributions. Depression is one of the largest contributors to chronic disease burden; it affects more than one in six individuals in the United States. A wide array of cellular and molecular modifications distributed across a variety of neuronal processes and circuits underlie the pathophysiology of depression—no established mechanism can explain all aspects of the disease. MDD suffers from a vast treatment gap worldwide, and large numbers of individuals who require treatment do not receive adequate care. This mini-review focuses on dysregulation of brain dopamine (DA) systems in the pathophysiology of MDD and describing new cellular targets for potential medication development focused on DA-modulated micro-circuits. We also explore how neurodevelopmental factors may modify risk for later emergence of MDD, possibly through dopaminergic substrates in the brain.

Background. Social cognition deficits are a core feature of psychiatric disorders, such as schizophrenia and mood disorder, and deteriorate the functionality of patients. However, no definite strategy has been established to treat social cognition (eg, emotion recognition) impairments in these illnesses. Here, we provide a systematic review of the literature regarding transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) for the treatment of social cognition deficits in individuals with psychiatric disorders. Methods. A literature search was conducted on English articles identified by PubMed, PsycINFO, and Web of Science databases, according to the guidelines of the PRISMA statement. We defined the inclusion criteria as follows: (1) randomized controlled trials (RCTs), (2) targeting patients with psychiatric disorders (included in F20-F39 of the 10th revision of the International Statistical Classification of Diseases and Related Health Problems [ICD-10]), (3) evaluating the effect of tDCS or rTMS, (4) reporting at least one standardized social cognition test. Results. Five papers (3 articles on tDCS and 2 articles on rTMS) met the inclusion criteria which deal with schizophrenia or depression. The significant effects of tDCS or rTMS targeting the left dorsolateral prefrontal cortex on the emotion recognition domain were reported in patients with schizophrenia or depression. In addition, rTMS on the right inferior parietal lobe was shown to ameliorate social perception impairments of schizophrenia. Conclusions. tDCS and rTMS may enhance some domains of social cognition in patients with psychiatric disorders. Further research is warranted to identify optimal parameters to maximize the cognitive benefits of these neuromodulation methods.

Introduction: Fatigue is a frequent and debilitating symptom for people with end-stage kidney disease (ESKD) receiving dialysis. Ecological momentary assessment (EMA) allows real-time data capture of day-to-day and diurnal variations. EMA has been used to study haemodialysis-related fatigue but not in people receiving peritoneal dialysis who are unique in their physical, environmental and logistical characteristics. The aim of this study is to explore the real-time associations between fatigue and mood (EMA mobile application) and objective physical activity levels (accelerometry) in people with EKSD receiving peritoneal dialysis. Method: A 7-day intensive longitudinal study will be conducted. People receiving peritoneal dialysis within South Australia will be invited to participate. Five times throughout the day, participants will be prompted to answer 18 questions relating to fatigue (Visual Analogue Scale to Evaluate Fatigue Severity) and a single question for mood (Visual Analogue Mood Scale). Participants will continuously wear a GENEActiv accelerometer to capture physical activity levels during the 7-day period. At the completion of the data collection, participants will answer questions to evaluate the feasibility and acceptability of using EMA. Discussion: This study will be the first to explore the real-time relationships between fatigue, mood and physical activity in people with ESKD receiving peritoneal dialysis. Understanding the fluctuations people experience and the relationships between mood and physical activity and fatigue will inform clinical management and well-being intervention development.

Individual differences in human temperament influence how we respond to stress and can confer vulnerability (or resilience) to emotional disorders. For example, high levels of behavioral inhibition in children predict increased risk of mood and anxiety disorders in later life. The biological underpinnings of temperament are unknown, although improved understanding can offer insight into the pathogenesis of emotional disorders. Our laboratory has used a rat model of temperamental differences to study neurodevelopmental factors that lead to a highly inhibited, stress vulnerable phenotype. Selective breeding for high versus low behavioral response to novelty created two rat strains that exhibit dramatic behavior differences over multiple domains relevant to emotional disorders. Low novelty responder (bLR) rats exhibit high levels of behavioral inhibition, passive stress coping, anhedonia, decreased sociability and vulnerability to chronic stress compared to high novelty responders (bHRs). On the other hand, bHRs exhibit high levels of behavioral dis-inhibition, active coping, and aggression. This review article summarizes our work with the bHR/bLR model showing the developmental emergence of the bHR/bLR phenotypes, the role the environment plays in shaping it, and the involvement of epigenetic processes such as DNA methylation that mediate differences in emotionality and stress reactivity.

Background: Breakfast skipping has been related to poor mood, but the role of sleep in this relationship remains unclear. Aim: To evaluate whether breakfast skipping associated with mood independently of sleep, and whether sleep interacted with breakfast skipping. Methods: During an in-person research visit, a sample of 329 adults completed questionnaires regarding last night’s sleep, current morning breakfast intake, and mid-morning mood states. Sex-stratified linear regression models examined associations between breakfast skipping and mood and interactions with sleep. Results: Among males, those who did not consume breakfast had less vigor independent of sleep (β=−2.72 with 95% CI −4.91, −0.53). Among females, those who did not consume breakfast had higher feelings of anxiety (β=1.21 with 95% CI −0.04, 2.47). Interaction analyses revealed that males with longer time to fall asleep and longer night-time awake time had higher depression scores in the presence of breakfast skipping, and females with more night-time awake time and shorter duration had higher fatigue and less vigor if they were also breakfast skippers. Conclusion: Breakfast skipping and poor sleep may jointly affect mood.

Depression is a persistent state of low mood, low energy or anhedonia and is considered a common mental disorder. It is associated with a wide range of significant emotional, psychological and physical symptoms. It can have a significant impact on people’s functioning, and mental ill health is estimated to cost the UK economy £94 billion per year. An estimated 40% of GP consultations are about mental health, and it is important that depression is appropriately diagnosed and managed. This article reviews the most recent National Institute for Health and Care Excellence guidelines and also gives special consideration to managing depression alongside physical comorbidities and in patients from different cultures.

Objective The coronavirus disease 2019 (COVID-19) appears to be the largest pandemic of our times. The aim was to recognize the risk factors for nonpsychotic postpartum mood and anxiety disorders (NPMADs) in women during the pandemic and state of emergency police lockdown in Serbia. Methods We assessed 108 postpartum women who completed the Edinburgh Postnatal Depression Scale (EPDS) and an additional survey constructed for this study. We also used the additional, previously mentioned survey, in 67 healthy age-matched women with children who were ≥2 years of age. The additional survey allowed us to gain insight into the impact of the pandemic as well as postpartum period on the risk of NPMADs. Results In 16 (14.8%) subjects we found a score ≥10 on EPDS. Higher rates on the EPDS were noticed in elderly, single, and unemployed, women who lost their jobs due to the pandemic, or women who were dissatisfied with their household income (p Conclusion Understanding the factors that increase the risk of NPMADs during the pandemic could help prevent mental disorders during a possible future pandemic.

The purpose of this study was to investigate the effects of interior color schemes in immersive virtual environments (IVEs) on emotion, task performance, and heart rate to examine IVEs’ potential for interior color research. Fifty–five ( n = 55) student participants were recruited to experience four different colored IVE models (i.e., red, green, blue, and white), and their emotions, heart rate change, and proofreading performances during the immersion were measured. Participants were also asked about their sense of presence after the experience. The findings support the following three hypotheses: (1) IVE interior color schemes affect subject emotion, (2) IVE interior color schemes affect subject task performance as measured through a proofreading exercise, and (3) IVE interior color schemes affect subject heart rate. Specifically, red was perceived as significantly heavier, warmer, more exciting, tenser, and unpleasant. Significantly fewer errors occurred during the white immersion versus the green color scheme when completing the task performance exercise. While heart rate was reduced for each color, significant decreases were detected in the blue, white, and green color scenarios. The majority of participants felt a sense of being there when experiencing the four colored IVE spaces. Based on these results, we conclude that IVE has potential for interior color research to overcome the limitations of traditional color research tools.

If the politics of aspirational construction appeal to the enchantment of infrastructure, reconstruction usually takes as given an environment of post-conflict, natural disaster, or the degradation of systems of preservation or resource management. If construction and conservation are taken as markers of continuity and political stability what does the urge to build again say about those who exert these ideas in advancement of a set of common goals? Shaped through multi-sited ethnography in Pakistan and the United Arab Emirates, this essay explores the mediation of mood and its material speculations. Concepts borrowed from both the preservation of the moving image and digital forms of heritage restoration provide ways of rethinking the place of reconstruction and coming to a new understanding of its sensual and atmospheric terrain.