1. Platelet to Lymphocyte Ratio as a Prognostic Marker of In-Hospital and Long-Term Major Adverse Cardiovascular Events in ST-Segment Elevation Myocardial Infarction.
- Author
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Ozcan Cetin, Elif Hande, Cetin, Mehmet Serkan, Aras, Dursun, Topaloglu, Serkan, Temizhan, Ahmet, Kisacik, Halil Lutfi, and Aydogdu, Sinan
- Subjects
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ACADEMIC medical centers , *BIOMARKERS , *BLOOD platelets , *CHI-squared test , *CONFIDENCE intervals , *CORONARY disease , *CREATINE kinase , *DOPPLER echocardiography , *FISHER exact test , *INFLAMMATION , *LONGITUDINAL method , *LYMPHOCYTES , *MYOCARDIAL infarction , *MYOCARDIAL revascularization , *PROBABILITY theory , *STATISTICS , *SURGICAL stents , *TRANSLUMINAL angioplasty , *MULTIPLE regression analysis , *PROPORTIONAL hazards models , *DATA analysis software , *DESCRIPTIVE statistics , *HOSPITAL mortality , *KAPLAN-Meier estimator , *ODDS ratio , *KRUSKAL-Wallis Test , *PROGNOSIS - Abstract
We assessed the prognostic value of the platelet to lymphocyte ratio (PLR) on in-hospital and long-term major adverse cardiovascular events (MACEs) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) in a large prospective study. Patients (n = 1938) admitted with acute STEMI within 12 hours of symptom onset and who underwent pPCI between January 2010 and January 2015 were followed up for 31.6 ± 16.2 months. During the in-hospital and long-term follow-up period, MACE, the prevalence of stent thrombosis, nonfatal myocardial infarction, and mortality were higher in the third PLR tertile group. A PLR in the third tertile had 2.4-fold increased risk of in-hospital MACE and 2.8-fold risk of long-term MACE. The PLR was significantly and positively correlated with peak creatine kinase MB (CK-MB) levels (r = 0.562, P < .001) and Gensini score (r = 0.408, P < .001). Kaplan-Meier analysis of long-term MACE-free survival revealed a higher occurrence of MACE in the third PLR tertile group compared to the other tertiles. In conclusion, the PLR may be a marker of inflammatory and prothrombotic status and predicted in-hospital and long-term MACE in a population with STEMI. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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