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The prevalence of health misinformation on social media could significantly influence individuals' health behaviors. To examine the prevalent topics, propagation, and correction of coronavirus disease 2019 (COVID-19) misinformation, automated content analyses were conducted for posts on Sina Weibo, which is China's largest microblogging site. In total, 177,816 posts related to COVID-19 misinformation during the COVID-19 outbreak in China were analyzed. The structural topic modeling identified 23 valid topics regarding COVID-19 misinformation and its correction, which were further categorized into three general themes. Sentiment analysis was conducted to generate positive and negative sentiment scores for each post. The zero-inflated Poisson model indicated that only the negative sentiment was a significant predictor of the number of comments (β = 0.003, p < 0.001) but not reposts. Furthermore, users are more prone to repost and comment on information regarding prevention/treatment (e.g., traditional Chinese medicine preventing COVID) as well as potential threats of COVID-19 (e.g., COVID-19 was defined as an epidemic by World Health Organization). Health education and promotion implications are discussed. [ABSTRACT FROM AUTHOR]