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Mesonephric-like adenocarcinoma (MLA) of the endometrium shows a variety of morphologic appearances, including small glands, tubules with eosinophilic materials in the lumen, prominent papillary patterns, spindled cells, solid formations, and corded and hyalinized patterns. Unique morphology, characteristic immunohistochemical staining patterns, molecular alterations, and awareness of the pathologists make it possible to identify this tumor accurately. This report of two additional morphologic patterns, intestinal goblet cells mimicking intestinal-type mucinous carcinoma and squamous differentiation with spindle and epithelioid cells mimicking carcinosarcoma of the endometrium will expand the literature on MLA. [ABSTRACT FROM AUTHOR]

While histological diagnosis of Paget disease of vulva is mostly straightforward, identifying and confirming invasion can be challenging. Often invasion is accompanied by epidermal hyperplasia, marked inflammatory response and desmoplastic reaction. Diagnosis of invasion in Paget disease portends a poor outcome. We report findings from a recurrent primary vulvar Paget disease where overall histomorphology of possible invasive disease is unusual and raises a possibility of displacement of Paget cells in the dermis. We compare histology of the index case with known invasive vulvar Paget disease cases retrieved from our pathology archives. Unique histomorphology in the index case suggests a possibility of previous excision related dermal displacement of Paget cells. [ABSTRACT FROM AUTHOR]

During breast cancer staging, histological evaluation of axillary sentinel lymph nodes (SLN) is usually straightforward. However, the exact characterization of a small epithelial deposit in an SLN can be challenging, especially during the frozen section examination. We report the first case of endosalpingiosis involving bilateral axillary lymph nodes. We review published literature on axillary endosalpingiosis and discuss the differential diagnosis of small epithelial deposits in an axillary SLN. Pathologists should consider benign epithelial rests and displaced epithelium as differential diagnoses for the microscopic epithelial nodal deposit, especially during the frozen section examination. [ABSTRACT FROM AUTHOR]

Interpretation of this finding can be confusing resulting in significant interobserver variability even among gynecologic pathologists.[1] It is critical to distinguish bona fide clear cell carcinoma from other endometrial lesions as management is significantly different. The papillae were lined by a single layer of eosinophilic and clear cuboidal cells with hyperchromatic nuclei, focal hyalinization, and neutrophilic infiltration (Figure 2A). The tumor was positive for Napsin A (Figure 3B), consistent with endometrial clear cell carcinoma. [Extracted from the article]

Gastric-type adenocarcinomas of the uterine cervix have been described within the literature in detail; however, the description of gastric-type endometrial adenocarcinomas is a recent development, with only two cases originating from Japan in the world literature to date. According to these prior reports, the recognition of this pattern of differentiation is critical, as it is often associated with deep myoinvasion, positive regional lymph nodes, and poor outcome despite appropriate adjuvant treatment. We present two cases of endometrial adenocarcinoma with gastric-type differentiation in patients from the United States with superficial myoinvasion and positive patient outcomes. Gastric-type differentiation in endometrial adenocarcinomas is rare and likely underrecognized. Continued reporting of these cases is necessary to further understand the natural history and clinical implications of this entity. [ABSTRACT FROM AUTHOR]

(A) Alternating mucinous and ciliated epithelia, mucinous epithelia with cilia, acidic, blue mucin, and neutral mucin (hematoxylin and eosin [H&E] 40×); (B) Predominantly low columnar mucinous epithelia (H&E 40×); (C) Exceedingly tall columnar mucinous epithelia (H&E 40×); (D) Bird's eye view of the seromucinous cystadenoma (H&E 4×). Microscopic examination revealed a cystadenoma lined by 2 types of epithelia: tubal-type ciliated epithelium alternating with endocervical-type mucinous epithelium. Seromucinous tumors, introduced in the 2014 World Health Organization classification as one of the categories of ovarian epithelial tumors, are defined as neoplasms with 2 or more Müllerian epithelial cell types.[1] Benign tumors of this category are rare and may represent fewer than 1% of benign epithelial neoplasms of the ovary.[1],[2] We report a case of a 55-year-old female who presented with back pain and was found to have a complex cystic lesion of the left adnexa by computed tomography examination. [Extracted from the article]

The so-called "corkscrew"-shaped I Helicobacter heilmannii i , usually found in cats, pigs, and other primates, is a large (0.5 µm × 5-10 µm), strongly urease-positive, gram-negative rod accounting for 0.2% to 4% of human gastritis cases; hence, it is a candidate for zoonotic infection, along with I Campylobacter i , I Salmonella i , I Yersinia i , I Listeria i , among others.[1][2] [3] It causes a relatively milder form of gastritis clinically and histologically confined to the gastric antrum (Figure 1a and b). Like I H. pylori i , the organism stains with both polyclonal and monoclonal I H. pylori i immunohistochemical stains (Figure 1e). [Extracted from the article]

Combined blue nevus and benign nevus cells were identified in the same sentinel lymph node. Blue nevus alone was also present in an additional sentinel lymph node in the same axilla in a patient who underwent needle localization, wide local excision, and sentinel lymph node biopsy for her pT1cN1mi(sn)M(na) invasive duct carcinoma of the breast. Of the 4 sentinel lymph nodes, 1 showed micrometastasis and 2 other lymph nodes showed blue nevus involving the capsule and trabeculae of the nodes. The patient had no significant previous clinical history of any skin tumors and had a negative clinical examination for malignant melanoma or pigmented skin lesions after the diagnosis of nodal blue nevus. To our knowledge, this is the first case report of combined blue nevi involving multiple sentinel lymph nodes in the same axilla. An equally interesting finding is the presence of benign nonpigmented nevus cells in continuation with the blue nevus in the same node. [ABSTRACT FROM AUTHOR]

A 40-year-old woman underwent excision of a painless left vulvar mass. The specimen showed a well-circumscribed mass measuring 3.5 × 2.7 × 2.5 cm. Microscopic examination exhibited an encapsulated neoplasm with a solid and papillary growth pattern. The tumor cells were oval to columnar and showed moderate nuclear atypia. No capsular invasion was identified. Immunonegativity for calponin and p63 confirmed the absence of myoepithelial cells either within or at the periphery of the tumor. The tumor was immunopositive for gross cystic disease fluid protein 15, synaptophysin, and chromogranin. The histologic and immunohistochemical characteristics were consistent with an encapsulated solid papillary carcinoma with neuroendocrine differentiation. The patient has been free of disease for 4 years after surgery. This is the first report of a vulvar encapsulated solid papillary carcinoma with neuroendocrine differentiation. Correct diagnosis is imperative because of the distinct biologic behavior of the tumor. [ABSTRACT FROM PUBLISHER]

Endometrial intraepithelial neoplasia[1] and endometrial intraepithelial carcinoma (EIC)[2] are 2 known precursors of endometrioid and serous type endometrial carcinomas, respectively. Graph: Figure 1. 1a: Low magnification view of endometrial polyp with Clear cell carcinoma in-situ (CCEIC) (HEx2x); 1b. [Extracted from the article]

The article present a case study of a 63-year-old woman with abdominal discomfort and was found to have a large pelvic mass on imaging. It mentions Hysterectomy with bilateral salpingo-oophorectomy revealed a 13×10×5 cm intact right solid adnexal mass with attached dilated fallopian tube; and also mentions Gross inspection revealed a yellowish-white solid firm multilobulated mass with shiny outer surface.

The article presents a case study of a 57-year-old female presented with 2 left vulvar masses. It discusses the histological examinations revealed the Verrucous carcinoma (VC) as a histologic subtype of squamous cell carcinoma characterized by highly differentiated squamous cells with a bulbous invasive pattern of the underlying stroma often associated and confused with giant condyloma of Buschke-Löwenstein.

The article offers information on the challenges in the diagnosis of the fibroepithelial lesions of breast. Topics discussed include information on the breast lesions with epithelial and spindle cell components including the fibroadenoma, phyllodes tumor and the nodular pseudoangiomatous stromal hyperplasia (NPASH); discussions on the uniform stromal cellularity and minimal epithelial proliferation in NPASH.

The article presents a case study of 40-year-old woman with a history of abnormal uterine bleeding and trapped endometrial stromal cells created an appearance of small oval nuclei. Her immunohistochemical staining for CD10 displayed diffuse cytoplasmic staining in the endometrial stroma and mucin and glycogen stains were negative. It mentions endometrium pneumatosis (EP) has been proposed to be associated with possible infection and mucosal disruption.

The article discusses a case study of a 74-year-old postmenopausal woman who was diagnosed with cystic hypersecretory hyperplasia (CHH). Particular focus is given on the diagnosis of the disease and microscopic examination of the patient with subareolar palpable breast mass. It also presents several images which show CHH of breast.

The article focuses on study that determines the possible prognostic significance of the lymphocytic infiltration (LI) and subgroups of lymphocytes (CD3 and CD20) presence in the primary tumors of colon cancer. Topics discussed immunohistochemical phenotyping of the lymphocytes; patients operated for colorectal carcinoma; absence of correlation between any clinicopathological pattern; and prognosis that show influence of lymphocytes