Summary Orthostatic hypotension may occur either as a primary disturbance of the autonomic nervous system or as the consequence of another condition. Successful treatment involves identi-fying the subtype and pursuing a comprehensive treatment plan. Dedication This paper is dedicated to Barbara Straus MD, mother, wife, physician, soul mate, and source of all inspiration-BPG. Disclosure The authors report no confl icts of interest. References [1] Wieling, W. and VanLieshout, J.J. 1997. Maintenance of postural normotension in humans. In: Low P (ed) Clinical Autonomic Disorders. Philadelphia PA. Lippincott-Raven , 73–82.[2] Thompson, W.O., Thompson, P.K. and Dailey, M.E. 1988. The effect of upright posture on the composition and volume of the blood in man. T Clin. Invest ., 5:573–609.[3] Shepherd, R. and Shepherd, J.T. 1999. Control of the blood pressure and circulation in man. In: Mathias C. Bannister R. (eds) Autonomic Failure: A textbook of clinical Disorders of the Autonomic Nervous System, (4th edition) Oxford UK, Oxford University Press, 72–5.[4] Joyner, M. and Shepherd, T. 1997. Autonomic regulation of the circulation in Low P (ed.) Clinical Autonomic Disorders (2nd ed) Philadelphia, PA