1. Lack of association between clinical and ultrasound measures of disease activity in rheumatoid arthritis remission
- Author
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Kenneth F. Baker, Ben Thompson, Dennis W. Lendrem, Adam Scadeng, Arthur G. Pratt, and John D. Isaacs
- Subjects
Diseases of the musculoskeletal system ,RC925-935 - Abstract
Objectives: The objective of this study was to assess the prevalence of ultrasound (US) abnormalities and association with clinical parameters in rheumatoid arthritis (RA) clinical remission. Methods: Patients with established RA in clinical remission (DAS28-CRP 2.4) or seronegative non-inflammatory arthralgia (NIA) were studied as positive and negative controls, respectively. The association between individual dependent variables (synovial power Doppler and greyscale, tenosynovial greyscale, and erosions) and clinical parameters was assessed by multivariate ordinal logistic regression, with adjustment for multiple testing. Results: A total of 294 patients were included: 66 RA in remission, 146 active RA, and 82 NIA. Within the active RA group, significant associations were observed between swollen joint count and higher total synovial greyscale score (OR 1.17 95% CI 1.08–1.26, p
- Published
- 2020
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