1. Two different genetic markers for high and low myopia.
- Author
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Olmedo MV, Muñoz JI, Rodriguez-Cid MJ, Carracedo A, Gomez-Ulla FJ, and Salorio MS
- Subjects
- Acid Phosphatase analysis, Adolescent, Child, Genetic Markers, Humans, Myopia blood, Myopia classification, Rh-Hr Blood-Group System analysis, Myopia genetics
- Abstract
In myopia patients, Rh and acid phosphatase were typed in two groups: group 1 consisted of 214 patients with low myopia (-6 D or less); group 2 of 124 patients with high myopia (more than -6 D). Statistical analysis of the markers showed a good Hardy-Weinberg equilibrium for both groups. In the Rh system there was a significant difference between group 1 and the control population (p < 0.05), but not between group 2 and control (p > 0.1). In the case of ACP there was a significant difference between group 2 and the control population (p < 0.05), but not between group 1 and control (p > 0.25). We conclude that the observed association between myopia and Rh system (chromosome 1) involves low myopia, while the association between myopia and acid phosphatase (chromosome 2) involves high myopia. Further DNA research will lead to more specific results.
- Published
- 1992
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