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Your search keyword '"Tormod Bjørkkjær"' showing total 2 results
Start Over Author "Tormod Bjørkkjær" Publisher sage publishing
2 results on '"Tormod Bjørkkjær"'

1. Effects of Seal Oil on Meal-Induced Symptoms and Gastric Accommodation in Patients with Subjective Food Hypersensitivity: A Pilot Study

Author

Kine Gregersen, Ragna A. Lind, Tormod Bjørkkjaer, Livar Frøyland, Arnold Berstad, and Gulen Arslan Lied

Subjects
Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Background Food hypersensitivity is a prevalent condition with poorly characterized underlying mechanisms. In the present pilot study we investigated effects of seal oil and soy oil on meal-induced symptoms and gastric accommodation in patients with subjective food hypersensitivity (FH). Single dose experiment : On three consecutive days, 10 mL of seal oil, soy oil, or saline were randomly administered into the duodenum of 10 patients with subjective FH and 10 healthy volunteers through a nasoduodenal feeding tube 10-20 minutes before the ingestion of a test meal. Short-term treatment study : 24 patients with subjective FH were randomly allocated to 10 days’ treatment with either 10 mL of seal or soy oil, self-administrated through an indwelling nasoduodenal feeding tube, 3 times daily. In both experiments meal-induced abdominal symptoms and gastric accommodation were measured by visual analogue scales and external ultrasound respectively. Results Symptoms and gastric accommodation were not significantly influenced by single doses of seal or soy oil. When given daily for 10 days, seal oil, but not soy oil, reduced total symptom scores significantly ( P = 0.03). The symptomatic improvement was not associated with improvements in gastric accommodation. Conclusion Daily administration of seal oil may benefit patients with subjective FH. The beneficial effect of seal oil in patients with subjective FH can not be ascribed to improved gastric accommodation.

Published
2008
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2. No Protection against DSS-induced Colitis by Short-term Pretreatment with Seal or Fish Oils in Rats

Author

Gülen Arslan, Kari Erichsen, Anne Marita Milde, Lars Helgeland, Tormod Bjørkkjær, Livar Frøyland, and Arnold Berstad

Subjects
Medisinske Fag: 700::Klinisk medisinske fag: 750::Gasteroenterologi: 773 [VDP], lcsh:R5-920, Ratio omega-6 to omega-3, Medisinske Fag: 700::Klinisk medisinske fag: 750::Reumatologi: 759 [VDP], soy oil, Seal oil, Fish oil, Colitis, digestive system, seal oil, fish oil, lcsh:Infectious and parasitic diseases, Rats, rats, dextran sulfate, ratio omega-6 to omega-3, Complementary and alternative medicine, lcsh:RC109-216, Soy oil, lcsh:Medicine (General), Dextran sulfate
Abstract

Background Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) have modulating effects in several chronic inflammatory conditions. The aim of the present study was to test whether prior short-term dietary supplementation with n-3 (fish or seal oil) or n-6 (soy oil) PUFA rich oils would protect the development of dextran sulfate sodium (DSS)-induced colitis in rats. Methods Forty-eight male Wistar rats were divided into 6 groups: no intervention, sham, DSS, seal oil + DSS, fish oil + DSS and soy oil + DSS. Following 7 days of acclimatisation, 1 mL oil (seal, fish or soy) or distilled water (sham) was administered by gavage day 8 to 14. Colitis was induced by 5% DSS in drinking water from day 15 to 21. Rats were sacrificed on day 23. Histological colitis (crypt and inflammation) scores, faecal granulocyte marker protein (GMP) and quantitative fatty acid composition in red blood cells were measured. Results Pretreatment with fish or seal oils did not significantly influence DSS induced inflammation. In fact, all the oils tended to exacerbate the inflammation. Soy oil increased the mean crypt score ( P < 0.04), but not the inflammation score or GMP. The ratio of n-6 to n-3 fatty acids (FAs) was 11 to 1 and 10 to 1 in standard diet and in red blood cells of control rats, respectively. Following administration of DSS, the ratio fell in all treatment groups ( P < 0.001). The lowest ratios were seen in the groups receiving DSS + fish or seal oils (around 6 to 1). Conclusion Short-term pretreatment with fish or seal oils did not protect against subsequent induction of colitis by DSS in this rat model. Whether the high ratio of n-6 to n-3 FAs in the standard diet concealed effects of n-3 FA supplementation should be further investigated.

Published
2007

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