Search

Resumen: Se presenta el caso clinico de una mu-jer de 20 anos que presenta insuficiencia cardiaca de rapida instalacion, asociada a sintomas de infeccion respiratoria viral, 9 semanas post parto. Previamente habia presentado hipertension en el puerperio precoz. Se demostro una severa disfuncion sistolica (FE 12%). Se recupero con medidas convencionales del trata-miento de Insuficiencia cardiaca y finalmente recibio bromocriptina basado en reportes favorables de la lite-ratura respecto del uso de este farmaco. En el control al ano de su alta, se mantenia asintomatica pero persistia severa disminucion de la FE (18%) y dilatacion de ca-vidades izquierdas. Se revisa la informacion acerca de esta patologia. 1 Residente de Cardiologia. 2 Cardiologo. 3 Residente de Medicina Interna, 4 Medico Internista. Servicio de Cardiologia. Hospital San Juan de Dios. Universidad de Chile. Correspondencia: Dr. German Armijo.Hospital San Juan de Dios garmijo.md@gmail.com German Armijo 1 , Pilar Acuna 4 , Byron Sarango

SUMMARY: The objective of this work was identify the presence of interstitial cells of Cajal, muscle cells, nerves and androgen receptor positive cells in adult human testicle, using immunohistochemical detection for c-kit/CD-117, actin smooth muscle specific (ASMS), neurofilament (N) and androgen receptor (AR), respectively. The samples were obtained from patients (n= 10) with diagnosis of prostate cancer, with surgery of orchiectomy. Subsequently were processed by histology and for immunohistochemistry using specific antibodies. It showed the presence of cells c-kit/CD-117, with diverse degrees of positivity, distributed mainly in the interstitial peritubular area of the human testicle. The peritubular myoides cells were positive to the presence of the actin smooth muscle and androgen receptor. The neurofilaments elements (+) only were observed in the vascular tunic. The specific immunohistochemistry describe the presence of the interstitial cells of Cajal in human testicular interstitium, opening a new perspective for the functional interpretation of the testicular cellularity and tubular motility. Possibly associated functionally to peribubulars cells of smooth muscle to regulate the mobility of the seminiferous tubules, whose integration and function would be androgen dependent. The cells that express the c-kit receptor, were found exclusively in the interstitial compartment. This cellular type in addition of the muscular cells of peritubules and the absence of nervous fibers to the interior of the testicle, could be responsible for the regulation of tubular mobility, as it happens in the gastrointestinal apparatus.