1. Clerodane diterpenoids with potential anti-inflammatory activity from the leaves and twigs of Callicarpa cathayana.
- Author
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Wang Y, Lin J, Wang Q, Shang K, Pu DB, Zhang RH, Li XL, Dai XC, Zhang XJ, and Xiao WL
- Subjects
- Animals, Anti-Inflammatory Agents isolation & purification, Cell Line, China, Diterpenes, Clerodane isolation & purification, Lipopolysaccharides metabolism, Magnetic Resonance Spectroscopy, Mice, Molecular Structure, Nitric Oxide metabolism, Phytochemicals isolation & purification, Plant Leaves chemistry, Plant Stems chemistry, Anti-Inflammatory Agents pharmacology, Callicarpa chemistry, Diterpenes, Clerodane pharmacology, Phytochemicals pharmacology, Plant Extracts chemistry
- Abstract
Phytochemical investigation of the leaves and twigs of Callicarpa cathayana led to the isolation of six new clerodane diterpenoids, cathayanalactones A-F (1-6), together with seven analogues (7-13). Their structures were established by extensive NMR analyses together with experimental and calculated ECD spectra analyses. Compounds 1, 2, 3, 7 and 11 showed inhibitory activities on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells., (Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.)
- Published
- 2019
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