1. Determination of Humectants in Tobacco Filler by High Performance Chromatography/Single Quadrupole Mass Spectrometry.
- Author
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Xizheng, Yan, Valentín-Blasini, Liza, Watson, Clifford, and Cardenas, Roberto Bravo
- Subjects
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HUMECTANTS , *CIGARETTES , *HIGH performance liquid chromatography , *ADDITIVES - Abstract
Glycerol, and 1,2-propylene glycol are the humectants most commonly used by the tobacco industry. They are found in a variety of tobacco products and are often present at high levels (~2–5 % w/w). While humectants are generally considered safe, they may serve as precursors in the formation of harmful carbonyl compounds. A selective, precise, and sensitive method for the quantification of several humectants in cigarette filler was developed. The method's sample clean-up is a two-step process consisting of a mechanical extraction, followed by solid phase extraction. Individual humectants are separated, identified, and measured using liquid chromatography coupled to a single quadrupole mass spectrometer as the detector (LC/MS). Detection limits were 0.105, 0.575, and 0.039 mg/cigarette for glycerol, 1,2-propylene glycol and triethylene glycol, respectively. The quantification range for these analytes was 0.4–75.0 mg/cigarette. Twenty-seven brands of domestic commercial cigarettes were evaluated to assess typical levels of humectants in the tobacco filler. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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