1. Influence of magnetic iron oxide nanoparticles on red blood cells and Caco-2 cells
- Author
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Delphine Felder-Flesch, Daniel Moersdorf, Ingolf Bernhardt, Hind Mamlouk-Chaouachi, Geneviève Pourroy, Lai Truonc Phuoc, Pierre Hugounenq, and Sylvie Begin-Colin
- Subjects
chemistry.chemical_compound ,chemistry ,Biochemistry ,Caco-2 ,Intracellular pH ,Biophysics ,Nanoparticle ,General Medicine ,Iron oxide nanoparticles ,Intracellular - Abstract
The interactions of two types of cells (red blood cells, Caco-2 cells) with magnetic iron oxide nanoparticles (non-grafted, citrate-grafted, dendrimer-grafted) of 11 nm in size have been investigated. We focused on two important physiological parameters of the cells, the intracellular pH and the intracellular Ca2+ content. The results show that the nanoparticles do not have a significant influence on the pH and Ca2+ content of Caco-2 cells. The Ca2+ content of red blood cells is also not affected but the intracellular pH is slightly reduced.
- Published
- 2010
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