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Hepatitis A virus (HAV) causes an acute hepatitis associated with significant elevatation in liver enzymes. The liver is main target of HAV and extrahepatic manifestations are scarce. The diagnosis of acute HAV infection is made by the detection of anti-HAV IgM antibody in patients with the typical clinical presentation.. Here in, we present a 22-year old male presented with malaise, fever, nause, and intensive stomach ache. In physical examination, the patient had fever, jaundice, and hepatomegaly. Laboratory tests resulted in elevated liver enzymes. Abdominal ultrasonography demonstrated thickening of the gallbladder wall, and intramural air. As the patient's symptoms failed to regress in follow up laparoscopic cholecystectomy was performed. To sum up, HAV infection can be seen in all age groups, in developing countries, such as our country. It must be kept in mind that, although very rarely, HAV infections may exhibit extrahepatic complications. [Dis Mol Med 2015; 3(1.000): 5-7]

Objectives: The purpose of this trial was to investigate in patients with sepsis, the correlation between prognosis ofdisease and factors, which influence prognosis like gender, focus of infection, bacterial growth in blood culture, growingpathogens in addition to serum levels of cytokines (TNF-α, IL-10, leptin) and C-reactive protein.Material and methods: Forty-six adult patients with sepsis and 55 healthy adults as control group were enrolled in thisstudy. Serum cytokine (TNF-α, IL-10 and leptin) levels were determined by ELISA method and C-reactive protein (CRP)levels were measured by nephelometric method. Serum cytokine and CRP levels on day 0 (initial), day 3 and day 5 werecompared in surviving sepsis patients and patients who died because of sepsis.Results: Serum IL-10 level on day 0 (initial) of adult patients who died as a result of sepsis was found to be higher thansurviving patients and the difference was statistically significant (p=0.025). On 3rd day of treatment, serum TNF-α andCRP levels of patients who dies because of sepsis were higher than values of surviving patients (for TNF-α p=0.033, forCRP p=0.026). In adult patient group with sepsis who died on the 5th day of treatment, serum TNF-α level was significantlyhigher than levels in surviving patients (p=0.030).Conclusion: It was determined that in patients who died due to sepsis, initial serum IL-10 level, TNF- α and CRP levelson 3rd day of treatment and finally on 5th day of treatment, only serum TNF- α level was higher than surviving patients.We believe that determining serum TNF-α and IL-10 levels in patients with sepsis before and during treatment will helpclinicians to clarify prognosis and enable them to implement appropriate treatment modifications. J Microbiol Infect Dis2011; 1(3):101-109

AIM: This study aims to compare point prevalence results which were done with one year interval in a university hospital with a 1,200-bed capacity. METHODS: The study assessed antibiotic usage among all hospitalised patients in the hospital on April 20, 2012 and April 19, 2013, using the point prevalence method. The assessment was carried out by an infectious disease specialist relying on the basic principles of antibiotic usage and current antimicrobial treatment guides. The causes of antibiotic usage were classified under three groups, namely, empirical, infection diagnosis and prophylactic. Data were transferred to computer and analysed using SPSS 15.0. We used the chi square method for comparisons of categorical variables. P values

Objective: Fever of whatever etiology still remains a perplexing problem to both clinicians and investigators. Increasingly, its role in connective tissue diseases, malignancies and other inflammatory disorders is slowly supplanting the exclusivity of the symptom to just infectious conditions. This study aims to determine the sensitivity of the naproxen test and the diagnostic value in patients with a prolonged febrile illness. Methods: We evaluated twenty patients had been administered the naproxen test. Fever lysis after or within the time frame of drug administration was interpreted as a infectious or an infectious condition. Results: Infectious diseases etiology was detected at 15 patients. 12 and 3 of them responded to naproxen test at the first and second days respectively. Two of non-infectious etiology patients remained unanswered. Conclusion: This study clearly showed that the naproxen test cannot be relied upon to guide diagnostic decision making in patients with fever unknown origin. [TAF Prev Med Bull 2012; 11(6.000): 779-782]

Malaria has frequently been seen in the East Mediterranean and Southeast Anatolia and rarely seen in other regions. Both in the world and Turkey the most seen agent is Plasmodium vivax. Malaria is the fifth infection in the world that leads to death. Associated with travel Plasmodium falciparum and also P.vivax cases have been seen more and more often. An importe P.vivax case is presented in this article. [TAF Prev Med Bull 2011; 10(5.000): 617-620]