1. Determination of Predictive Anatomic Parameters for Bleeding of Brain Arteriovenous Malformations by Multidetector CT Angiography
- Author
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Biljana Milatović, Goran Tasić, Igor Nikolić, Igor Đorić, Nikola Repac, Vuk Šćepanović, Aleksandar Janićijević, Krešimir Rotim, Lukas Rasulić, Biljana Milatović, Goran Tasić, Igor Nikolić, Igor Đorić, Nikola Repac, Vuk Šćepanović, Aleksandar Janićijević, Krešimir Rotim, and Lukas Rasulić
- Abstract
Patients with brain arteriovenous malformation (AVM) have a certain risk to bleed, and the goal of this study was to examine the effect of radiological and clinical predictive characteristics of AVM hemorrhage using multidetector computed tomographic (MDCT) angiography. The study included a series of 57 patients, mean age 35.46 years, who were diagnosed during their hospitalization at Clinical Department of Neurosurgery, Clinical Center of Serbia, in the period from January 2008 to March 2016. In all patients, the diagnosis was made using MDCT angiography. Two groups of patients were observed. The first group included patients who did not initially present with hemorrhage, while the second group initially presented with hemorrhage. Both groups were treated with medical therapy or a combination of medical therapy with embolization/surgery/radiotherapy. Deep venous drainage (p<0.05), combined arterial supply from different basins (p<0.05) with a length >60 mm, venous dilatation present in the drainage vein (p<0.01), and the angle of casting sup-ply arteries in the nidus (p<0.01) carry a risk of repeated bleeding. In the group of patients who had initial hemorrhage, the mean value of the casting angle size was 130°, while in the group that did not have initial bleeding the mean value of the measured angle size was 103.81° with standard deviation of 17.21° (p<0.01). In conclusion, AVMs with deep venous drainage from the carotid and vertebrobasilar basin, the length of the feeding arteries >60 mm, the angle of the casting feeding arteries in the nidus ≥130° and dilatation and/or venous aneurysm of drainage vessel are predictive for clinical presenting by hemorrhage., Bolesnici s arteriovenskim malformacijama mozga (AVM) imaju određen rizik za krvarenje pa je cilj ove studije bio ispitati utjecaj radioloških i kliničkih prediktivnih karakteristika AVM za hemoragiju pomoću multidetektorske CT angiog-rafije (MDCTA). U studiju je bilo uključeno 57 bolesnika srednje dobi od 35,46 godina kojima je dijagnoza postavljena na Institutu za radiologiju i magnetskom rezonancijom dok su bili hospitalizirani na Klinici za neurologiju Kliničkog centra Srbije u razdoblju od siječnja 2008. do ožujka 2016. godine. Svim bolesnicima je dijagnoza postavljena pomoću MDCTA. Praćene su dvije skupine bolesnika. Jednu skupinu činili su bolesnici kod kojih se AVM u početku nije manifestirala krva-renjem, dok se druga skupina odmah prezentirala hemoragijom. Obje skupine su liječene medikamentnom terapijom ili kombinacijom medikamentne terapije s embolizacijom/kirurškom intervencijom/radioterapijom. Duboka venska drenaža (p<0,05), kombinirani arterijski dovod iz različitih slivova (p<0,05) s dužinom >60 mm, prisutna venska dilatacija na dre-nažnoj veni (p<0,01) i kut ulijevanja dovodnih arterija u nidus (p<0,01) nosili su rizik ponovljenog krvarenja. U skupini bolesnika koji su imali inicijalnu hemoragiju srednja vrijednost veličine kuta ulijevanja je bila 130o, dok je u skupini koja nije imala inicijalno krvarenje srednja vrijednost izmjerenog kuta bila 103,81o sa standardnom devijacijom 17,21o (p<0,01). U zaključku, AVM s dubokom venskom drenažom iz karotidnog i vertebrobazilarnog sliva, dužinom dovodne arterije >60 mm, kutom ulijevanja dovodne arterije u nidus ≥130° i dilatacijom i/ili aneurizmom drenažne vene su prediktivni model za kliničko prezentiranje hemoragijom.
- Published
- 2017