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Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To analyze the predictive value of plasma transforming growth factor-β1 (TGF-β1) and bone morphogenetic protein-7 (BMP-7) levels for bronchopulmonary dysplasia (BPD) in premature infants. Methods A total of 500 cases of premature infants were selected as the study objects. According to the occurrence of BPD, they were divid‑ ed into the BPD group (185 cases) and the non-BPD group (NBPD group, 315 cases). The difference of TGF-β1, BMP-7 and general clinical data between the two groups were compared, and the predictive value of TGF-β1 and BMP-7 for premature infants with BPD was analyzed. Results The mechanical ventilation time, oxygen absorption concentration, oxygen absorption time, the proportion of respiratory distress syndrome and the rate of spontaneous delivery in children in the BPD group were significantly higher than those in the NBPD group, while the birth weight and Apgar score (1 min, 5 min) were significantly lower than those in the NBPD group (all P<0. 05). The plasma levels of TGF-β1 and BMP-7 in the BPD group at birth and after birth (day 7, day 14, day 21) were higher than those in the NBPD group at the same time point (all P< 0. 05). Logistic multivariate regression analysis showed that spontaneous delivery, oxygen absorption time, mechanical ventilation time, TGF-β1 and BMP-7 were all risk factors for BPD premature infants (all P<0. 05). The area under ROC curve (AUC) of TGF-β1 and BMP-7 plasma at birth were 0. 757 and 0. 808, respectively, and the AUC of TGF-β1 combined with BMP-7 was 0. 848, which was higher than any single indicator of TGF-β1 and BMP-7 (all P<0. 05). Conclusion Plasma TGF-β1 and BMP-7 are independent risk factors for BPD in premature infants, and combined detection of them can improve the predictive efficacy [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 观察沙利度胺对原发性肝癌(HCC)患者介入治疗后T淋巴细胞和红细胞免疫功能的影响. 方法将100例中晚期HCC患者随机分为观察组及对照组各50例. 两组均采用改良Seldinger法行经皮导管动脉化疗栓塞术,观察组介入治疗1周后给予沙利度胺口服100~200 mg,1次/d,时间至少3个月;对照组介入治疗后未予沙利度胺口服,介入治疗1、13周后采用微量全血直接免疫荧光法检测T淋巴细胞,采用受体黏附法检测红细胞免疫功能变化. 结果 观察组介入治疗13周后总T细胞(CD3+)、辅助/诱导T淋巴细胞(CD4+)、CD4+/CD8+和肿瘤红细胞花环(DTER)、红细胞C3b受体花环(RBC-C3bRR)显著高于同组介入治疗1周后及对照组介入治疗13周后(P均<0.05),红细胞免疫复合物花环(RBC-ICR)显著低于同组介入治疗1周后及对照组介入治疗13周后(P均<0 .05 ). 结论 沙利度胺具有正向调节HCC患者T淋巴细胞及红细胞免疫功能的作用,可应用于HCC介入治疗后的细胞免疫调节的辅助治疗. [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)