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Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的, 观察依达拉奉右莰醇静脉滴注治疗急性动脉粥样硬化性脑梗死 (ACI)的临床效果, 并探讨其治疗 作用机制。方法, 选取120例ACI患者, 随机均分为实验组和对照组。两组均给予常规治疗, 实验组在常规治疗的 基础上, 加用依达拉奉右莰醇注射用浓溶液 15 mL, 将其溶于生理盐水100 mL中稀释后静脉滴注, 30 min内滴注完 毕, 每天2次；两组疗程均14 d。比较两组总有效率。治疗前和治疗14天, 对患者进行NIHSS评分 (评价神经系统缺 损程度)；治疗90 d, 对患者进行改良Rankin量表评分 (mRS评分, 评价独立生活能力), 计算mRS评分≤1分的患者比 例。治疗前和治疗14天, 采用ELISA方法检测两组的人甲壳质酶蛋白40 (YKL-40)、人可溶性CD40 (sCD40)。统计 两组治疗期间的不良反应发生率。结果, 实验组总有效率高于对照组 (P<0. 05)。与治疗前比较, 治疗后两组 NIHSS评分均降低, 以实验组为著 (P均<0. 05)。实验组治疗后90 d的mRS评分≤1分的患者比例高于对照组 (P均< 0. 05)。与治疗前比较, 治疗后两组YKL-40、sCD40水平均降低, 以实验组为著 (P均<0. 05)。两组治疗期间均未发 生严重不良反应事件。结论, 依达拉奉右莰醇静脉滴注治疗ACI有效、安全, 可有效改善患者神经功能缺损症状、 提高独立生活能力；依达拉奉右莰醇可能通过降低血清YKL-40、sCD40水平起治疗作用的。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 观察盐酸多奈哌齐联合尼莫地平治疗血管性痴呆患者的临床疗效。方法 将152例血管性痴 呆患者随机分为两组各76例,均按照脑血管病二级预防进行常规治疗;对照组给予尼莫地平治疗，观察组在对照 组基础上另予盐酸多奈哌齐治疗，连续服用8周。治疗前及治疗后第4、8周，分别采用蒙特利尔认知评估量表 (MoCA)及简易精神状态检查(MMSE)评价患者的认知功能，采用临床痴呆量表(CDR)评价患者的痴呆程度，采用 日常生活活动能力量表(ADL)评价患者的日常生活自理能力；治疗第8周评价临床疗效，记录不良反应。结果 两组治疗前河MMSE,MoCA,CDR,ADL评分比较，差异无统计学意义。两组治疗后第4、8周MMSE、MoCA评分均较 治疗前升高(P均<0. 05)，而CDR、ADL评分均较治疗前降低(P均<0.05);观察组治疗后MMSE、MoCA评分均较 高于对照(P均<0. 05)，而CDR、ADL评分均低于对照组（P均<0.05)。观察组显效率40. 8%、总有效率93.4%， 对照组分别为18.4%、85.5%，观察组显效率高于对照组(P<0.05)。两组不良反应发生率比较，差异无统计学意 义：结论盐酸多奈哌齐联合尼莫地平治疗血管性痴呆患者能够提高临床治疗效果，改善患者的认知能力、痴呆 程度以及日常生活能力。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的观察骨髓基质细胞衍生因子1(SDF-1)在慢性髓性白血病(CML)不同病程中的表达,并探讨其与临床参数的关系。方法选择CML患者30例及健康对照者12例,CML患者30例中,初治慢性期10例、慢性期获得主要分子学反应(MMR)10例(患者接受一代或二代TKI治疗)、急变期10例(接受TKI治疗疾病仍发生进展)。抽取骨髓,提取骨髓单个核细胞,采用实时定量PCR技术检测SDF-1 mRNA,比较CML与健康对照之间及不同病程CML患者之间SDF-1的表达差异,分析SDF-1 mRNA表达水平与CML患者临床参数间的关系。选取上述患者中CML初治慢性期患者6例、急变期4例的骨髓活检标本作为慢性期组及急变期组,并应用5例份无明显病变的骨髓活检标本作为对照组,应用免疫组化技术检测骨髓组织SDF-1蛋白的表达。结果与健康对照比较,CML初治慢性期患者、急变期患者骨髓单个核细胞SDF-1 mRNA表达水平降低(P均<0.05),CML慢性期治疗后获得MMR者SDF-1 mRNA水平与健康对照比较,P>0.05;CML急变期患者SDF-1 mRNA表达水平较CML初治慢性期患者高(P<0.05)。急变期组骨髓组织中SDF-1表达阳性率高于慢性期组(P<0.05),慢性期组与对照组比较P>0.05。SDF-1 mRNA低表达(<4.36×10-3)患者外周血白细胞计数高于SDF-1 mRNA高表达(≥4.36×10-3)者(P<0.05),而SDF-1 mRNA的表达与患者年龄、性别、血红蛋白、血小板计数、CD34+细胞比例、BCRABL1/ABL1、染色体核型均无相关性(P均﹥0.05)。结论 CML患者骨髓微环境中SDF-1表达降低,其水平降低与病情加重及白细胞升高有关。 [ABSTRACT FROM AUTHOR]

目的 观察自拟宜胃止痛抗幽汤辅助治疗幽门螺杆菌（HP)感染性胃脘痛的效果。方法将165例HP 感染性胃脘痛患者随机分为对照组82例和观察组83例。两组均给予奥美拉唑肠溶片、莫沙必利分散片、硫糖铝 混悬液、阿莫西林克拉维酸钾片治疗，观察组另口服自拟宜胃止痛抗幽汤加减治疗,3周为1个疗程。观察两组症 状积分、主要症状缓解情况和Hp清除率、中医脾胃系统疾病PRO量表和治疗效果。结果观察组治疗后胃脘痛、 痞满、嗳气、纳差缓解率和Hp清除率差异均有统计学意义(P均<0.05)。两组治疗后生理领域、独立性领域、心理 领域、社会和自然领域评分及总分均低于治疗前(P均< 0. 05);观察组治疗后上述各单项评分与对照组比较差异 无统计学意义(P均> 0.05),但总分低于对照组（P < 0. 05)。观察组临床治疗总有效率高于对照组，差异有统计 学意义(P <0.05)。结论自拟宜胃止痛抗幽汤辅助治疗Hp感染性胃脘痛可有效缓解患者临床症状，提高Hp 清除率及临床疗效。 [ABSTRACT FROM AUTHOR]

目的观察奥沙利铂、氟尿嘧啶筛选前后胃癌SGC7901细胞株中CD44v6/ATP结合转运蛋白G超家族成员2(ABCG2)表达变化。方法取对数生长期的胃癌SGC7901细胞株,分别用0、4、12、20、28、36μg/m L的奥沙利铂及0、30、50、70、90、110μg/m L的氟尿嘧啶进行干预,MTT法得到奥沙利铂、氟尿嘧啶作用于实验细胞株的最适浓度分别为30、28μg/m L。以最适浓度作用于实验细胞株分离出胃癌干细胞,以免疫细胞化学法、半定量RTPCR法、Western blotting法检测以上两种药物筛选前后细胞株中CD44v6/ABCG2的阳性表达率。再以单细胞悬浮成瘤实验、免疫细胞化学法检测次代干细胞级别的实验细胞株中CD44v6/ABCG2的阳性表达率。结果奥沙利铂、氟尿嘧啶筛选的干细胞级别的实验细胞株中CD44v6/ABCG2阳性表达率明显上调,能在低浓度血清培养基中形成悬浮肿瘤球,免疫细胞化学检测其次代细胞中CD44v6/ABCG2的阳性表达率又回到筛选前水平。结论奥沙利铂、氟脲嘧啶筛选后的细胞株中CD44v6/ABCG2阳性表达率明显上调,细胞株具有干细胞的特性。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

纤维化疾病的主要效应细胞是成纤维细胞。成纤维细胞可来源于内皮细胞向肌成纤维细胞转分化 (EndMT)过程中。血管内皮细胞具有较强的可塑性，不同组织血管床的血管内皮细胞在多种病理因素刺激以及多种 细胞因子的共同作用下均可发生EmlMT。EmlMT可通过多种生物活性分子包括转化生长因子p、血管紧张素II、微小 RNA，螺旋-环-螺旋转录因子(如Twist)和锌指转录因子（如Snail和Slug)等介导多种器官（如心脏、动脉、肺、肾） 发生纤维化改变。在EndMT发生过程中内皮细胞失去其本身特性，并表现出间质细胞特征，侵人和迁移能力增强，逐 渐转化为血管壁中的肌成纤维细胞，肌成纤维细胞可迁移到血管周围区域并参与组织纤维化过程。因此，EndMT与 心肌纤维化、移植动脉硬化及动脉粥样硬化、放射性肺纤维化、肾脏纤维化等疾病的发生均密切相关。 [ABSTRACT FROM AUTHOR]