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目的 探讨医用重组胶原蛋白联合 CO2 点阵激光治疗皮肤瘢痕的有效性及安全性。方法 选取皮肤瘢 痕患者54例, 按照随机数字表法分为两组各 27 例, 均行 CO2 点阵激光治疗。点阵激光治疗完成后, 对照组给予红霉 素软膏外用涂抹, 观察组给予医用重组胶原蛋白敷料外用涂抹, 均每天2次, 持续使用1个月。两组 CO2 点阵激光治 疗联合药物涂抹治疗, 每 2 个月进行 1 次为 1 个疗程, 共治疗 3 个疗程。采用温哥华评估量表 (VSS) 根据血管分布、色泽、厚度、柔软度情况对瘢痕形态进行评分, 视觉模拟评分 (VAS) 评估创面术后疼痛和瘙痒程度; 根据 VSS 评分计 算瘢痕改善率, 评价临床疗效, 治疗期间观察患者不良反应发生情况。采用酶联免疫吸附法测定两组血清转化生长 因子 β1(TGF-β1)、白细胞介素 6 (IL-6)、白细胞介素 8 (IL-8)。结果 治疗 3 个疗程, 两组 VSS 评分和 VAS 均较治疗前 降低, 且观察组 VSS 评分和 VAS 低于对照组 (P均<0. 05); 观察组治疗总有效率 (96. 30%) 高于对照组 (77. 78%), 不 良反应发生率 (7. 41%) 低于对照组 (25. 93%), 差异均有统计学意义 (P均<0. 05); 两组血清 TGF-β1、IL-6、IL-8 水平 均较治疗前降低, 且观察组血清 TGF-β1、IL-6、IL-8 水平低于对照组 (P 均<0. 05)。结论 医用重组胶原蛋白联合 CO2 点阵激光治疗皮肤瘢痕疗效好且安全性高。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To observe the effect and mechanism of different concentrations of 0 6 -cyclohexylmethylguanine ( 6 ) on cell proliferation, apoptosis and cell cycle of rat hypophysoma MMQ cell line. Methods MMQ cells (2 mL) in logarithmic growth phase were inoculated into 6-well plates, then we added 0. 4 and 4 μlmol of 06 and dimethyl sulfoxide (which were taken as the groups A, B, and C, respectively) . Cell viability assay was used to detect OD490 value, flow cytometry was used to detect the positive percentage of Annexin and PI, as well as the percentage of cells in the S and Gl phases, and Western blotting was used to detect the levels of Cdk2, p21 and p27 proteins. Results Compared with group C, the OD490 values of groups A and B decreased at 24, 48 and 72 h ( all P < 0. 05 ) . Compared with group C, the percentages of Annexin V positive cells and PI positive cells in the group A increased (P <0. 05 ). Compared with group B, the percentages of Annexin V positive cells and PI positive cells in the group A decreased ( P <0. 05). Compared with group C, the ratios of cells in the S phase were reduced and the ratios of cells in the Gl phase increased in the groups A and B (all P < 0. 05) . Compared with the group C, the Cdk2 levels in the groups A and B were reduced and the p27 level in the group A increased ( all P < 0. 05). Compared with group B, the Cdk2 levels increased, and p21 and p27 levels decreased in the group A (all P < 0. 05) . Conclusions 06 could inhibit the cell proliferation, induce the apoptosis and arrest the cell into Gl phase in MMQ cell line. The inhibition effect of 4 μlmol 06is stronger than that of 0. 4 μmol through inhibiting the activity of CDK2 protein. [ABSTRACT FROM AUTHOR]

目的 探讨完全性血运重建与部分性血运重建治疗冠状动脉多支病变(MVD)患者的近远期疗效。方法 选取接受PCI治疗的MVD患者174例，按照血运重建方式分为完全性血运重建组75例及部分性血运重建组99 例，两组性别、年龄、临床症状、体征等差异均无统计学意义(P均>0.05)。记录两组PCI治疗前后心肌缺血改善 情况、心功能各项指标、6 min步行试验(6MWDT)、N端前脑钠尿肽(NT-proBNP)变化情况、再次住院例数及心血管 不良事件(MACE)发生情况。结果两组血运重建后心肌缺血改善情况、心功能指标、6MWDT、MACE、再住院发 生情况差异无统计学意义(P均>0.05);血运重建前后比较，两组心功能指标及血液NT-PmBNP峰值浓度比较差 异有统计学意义(P均<0.05);两组慢性肾功能不全发生率比较差异有统计学意义(P均<0.05)。结论部分 性血运重建治疗MVD的近远期疗效与完全性血运重建相似，且并发慢性肾功能不全的发生率较完全性血运重 建低。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Tyro3、Axl和Mer受体酪氨酸激酶简称TAM受体，是受体酪氨酸激酶亚家族之一。 TAM受体的配体是结构相似的生长停滞特异性基因6(Gas6)和S蛋白(ProS)。 TAM受体和配体广泛表达于哺乳动物多种细胞表面，具有抑制细胞凋亡，促进细胞增殖，介导细胞黏附、迁移、吞噬等生理功能，参与机体的免疫调节。缺失TAM受体的小鼠患有慢性炎症和自身免疫病等免疫性疾病，这与TAM受体信号通路介导的清除凋亡细胞和抑制天然免疫等作用密切相关。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

体视学是一门新兴的交叉学科，是由组织器官和（或）细胞的二维测量数据，推论、分析其三维结构定量信息的一门科学。近几十年来，随着现代体视学方法的不断完善，定量体视学技术已广泛应用于生物医学领域。定量体视学技术在国外口腔医学领域应用范围广泛，包括口腔肿瘤病理学、口腔颌面外科学、口腔种植学、牙周病学、口腔黏膜病学、口腔材料学、口腔解剖学、口腔微生物学、口腔放射影像学等领域。但中国口腔医学中有关定量体视学技术的应用报道较少，应用范围也相对较窄，其应用多集中在口腔基础医学，主要包括口腔病理学及口腔解剖学领域。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)