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Objective To investigate the neuroprotective effect of electro-acupuncture on cerebral isehemia-reperfu-sion injury rats and its mechanism. Methods Ninety adult male SD rats were randomly divided into the sham operation group, model group and electro-acupuncture group, with 30 rats in each. The focal cerebral ischemia-reperfusion injury rat models in the model group and electro-acupuncture group were established by modified thread embolism method; the rats in the shamoperation group were only given blood vessel isolation without blocking blood vessel; the rats in the electro-acupuncture group were given electro-acupuncture at Baihui and Dazhui acupoint immediately after modeling, once every 12 h, 30 min each time, for 5 times. At 6 , 24 and 48 h after reperfusion, Longa method was used to score the neurological deficit. At 48 h after reperfusion, laser Doppler flow meter was used to detect the regional cerebral blood flow and velocity in the ischemic side. Ten rats in each group were randomly selected and decapitated to death, and their brain tissues were taken out quickly, evenly sliced. TTC staining was used to calculate the percentage of cerebral infarction volume; ten rats in each group were randomly selected and decapitated to death, and the cerebral cortex of ischemic side was taken to detect the apoptotic rate of neurons by TUNEL staining. The remaining rats were decapitated and their brain tissues were taken. The expression of Wnt/β-catenin signaling pathway key factor β-catenin protein, apoptosis-related factors Bel-2 and Bax protein in brain tissues were detected by Western blotting. Results Compared with the sham operation group, the cerebral blood flow and velocity decreased significantly, the scores of neurological deficit, the percentage of cerebral infarction area and the apoptotic rate of neurons increased, the expression of Bax protein in the brain tissue increased, and the expression of β-catenin and Bcl-2 protein decreased significantly in the model group ( all P <0.0 5). Compared with the model group, the cerebral blood flow and blood flow velocity increased, the scores of neurological deficit, the percentage of cerebral infarction area, and the apoptotic rate of neurons decreased, the expression of Bax protein in the brain tissues decreased, but the expression of β-catenin and Bcl-2 protein increased significantly in the electro-acupuncture group (all P <0. 05). Conclusion Electro-acupuncture has neuroprotective effect on cerebral ischemia-reperfusion injury rats by activating Wnt/β-catenin signaling pathway, inhibiting Bax protein expression, and promoting Bcl-2 protein expression. [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的观察结核病合并糖尿病(TB-DM) 患者经哦唉酰胺(PZA) 抗结核治疗后的商尿酸血症、痛风性关 节炎发生悄况。方法TB-DM 患者90 例（观察组） ，单纯结核病患者90 例（对照组） ， 两组患者均采用口服异烟阱 ＋ 利福平＋ 乙胺丁醇(HRE) 三联抗结核治疗。比较两组加用PZA 后商尿酸血症及痛风性关节炎发生悄况。结果 观察组PZA 治疗前后血尿酸水平分别为(257. 51 ±65. 75) 、(551. 80 ±189. 21) μ,moL/L，对照组分别为(267. 63 ± 68. 28) 、(352. 07 ±141. 62) μ,moL/L， 同组PZA 治疗前后及两组PZA 治疗后比较，P 均<0.05 ；观察组PZA 治疗后发 生商尿酸血症63 例(70. 00% ） ， 商尿酸血症发生时间(6. 8 ±2. 2) d； 对照组分别为31 例( 34. 44% ） 和( 12. 6 ± 2. 9) d；两组比较，P 均<0.05 ； 观察组PZA 治疗后血尿酸水平正常、轻度商尿酸血症、中重度商尿酸血症者空腹血 糖水平分别为(9.15±0. 61) 、(11. 82 ±0. 90) 、(14.12 ±0. 81) mmoL/L， 对照组分别为(4. 59 ±0. 45) 、（5. 75 ± 0. 22) 、（6. 15 ±0. 06) mmoL/L，观察组两两比较， 对照组血尿酸正常者与其余两者比较，P 均< 0. 05 。观察组及对 照组PZA 治疗后痛风性关节炎分别为11 例(12. 22% ） 、3 例(3. 33 ) % ， 待续时间分别为(17. 1 ±1.7) 、(9.3 ± 0.6) d， 两组比较，P 均<0.05 。结论较单纯结核病患者， TB-DM 患者经PZA 抗结核治疗后高尿酸血症发生率商、 程度重、发生时匝长，关节症状发病率商。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的探讨急性肺栓塞患者CT栓塞指数(PAQI)与右心结构和功能相关参数的关系。方法选择急性肺 栓塞患者120例，根据PAQI <30%、≥30 ~ <50%、≥50%分为轻度组43例、中度组40例、重度组37例。入组次日检 测血浆氨基末端脑钠肽前体（NT-PmBNP)，超声心动图测量右心室前壁厚度（RVAWTd)、右心室舒张末期容积 (RVEDV)、右心室收缩末期容积(RVESV)、右心室横径（RVTD)、右心室长径（RVLD)、右心房横径（RATO)、肺动脉 压力（SPAP)、右心室射血分数(RVEF)与右心室、右心房纵向收缩峰值应变（RVPSS、RAPSS)、纵向收缩峰值应变率 (RVPSSR、RAPSSR)以及三尖瓣环收缩期位移(TAPSE)，分析PAQI与右心结构和功能相关参数的关系。结果与轻 度组、中度组比较，重度组RVAWTd、RATD、RVTD、RVLD、RVEDV、RVESV、RVEF、SPAP等右心结构相关参数明显增 加(P均<0.05)，轻度组与中度组上述参数比较P均>0.05。轻度组、中度组、重度组RUPSS、RAPSS、RVPSSR、 TAPSE等右心功能相关参数逐渐减低，血浆NT-proBNP水平逐渐升高，组间两两比较P均<0.05。相关分析显示， PAQI 与 RVPSS、RVPSSR、TAPSE、RVEF、SPAP、NT-proBNP 均呈正相关关系（r 分别为 0.763、0.215、0.689、0.268、0.356、0.561，P <0.05或<0.01)。结论急性肺栓塞患者PAQI越大，右心结构变化越明显，右心功能越差。 [ABSTRACT FROM AUTHOR]

目的：探讨胸腔积液腺苷脱氨酶（ADA）／血清ADA和结核抗体（TB-Ab）联合检测对结核性胸腔积液的诊断价值。方法选择结核性胸腔积液患者58例（结核组）、恶性胸腔积液患者46例（肿瘤组）。采用ADA偶联谷氨酸脱氢酶连续检测法测胸腔积液和血清ADA水平；斑点金免疫渗滤试验检测胸腔积液和血清TB-Ab水平，并对两组各指标进行比较。结果结核组胸腔积液ADA水平和胸腔积液ADA／血清ADA均明显高于肿瘤组（P均＜0．01）。结核组TB-Ab阳性率明显高于肿瘤组（P＜0．05）。以胸腔积液ADA＞40 U／L作为诊断结核性胸腔积液的临界值，敏感性和特异性分别为82．8％和80．4％，准确率81．7％；以胸腔积液ADA／血清ADA＞1．0作为诊断结核性胸腔积液的临界值，敏感性和特异性分别为86．2％和84．8％，准确率85．6％。在结核性胸腔积液诊断中，TB-Ab敏感性68．9％，特异性78．2％，准确率73．1％；当联合胸腔积液ADA／血清ADA＞1．0和TB-Ab诊断结核性胸腔积液时，其敏感性、特异性和准确率分别上升到98．3％、95．6％和98．1％，敏感性及特异性均明显高于单项检测指标（P均＜0．01）。结论胸腔积液ADA／血清ADA和TB-Ab联合检测对结核性胸腔积液具有较好的诊断价值，优于单指标检测。 [ABSTRACT FROM AUTHOR]