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The coupling coordination of scientific and technological innovation, ecological environment, and economic development is an effective way for China to achieve high-quality development in the new development stage. The new infrastructure construction (hereinafter referred to as 'new infrastructure') with digital technology as the core provides new momentum for China's high-quality coordinated development. Guided by the new development concept and based on system theory and synergy theory, this study constructed a coupled coordination system of 'innovation-ecology-economy,' employed inter-provincial panel data from 2011 to 2020, and combined the spatial Durbin model with the mediating effect test method to empirically test the impact of new infrastructure on regional 'innovation- ecology-economy' coupling coordination. The findings indicated that: ① New infrastructure investments improved the level of regional 'innovation-ecology-economy' coupling coordination, generating strong positive spatial spillover and supporting both geographic distance matrix and economic distance matrix. ② Different types of new infrastructure investments contributed to the regional 'innovation- ecology-economy' coupling coordination, showing significant heterogeneity, where innovation infrastructure and convergence infrastructure had significant driving effects, while information infrastructure had a less obvious enabling effect. ③ New infrastructure investments fostered regional 'innovation-ecology-economy' coupling coordination through three transmission mechanisms: innovation factor concentration, energy efficiency improvement, and digital financial boost. Accordingly, Chinese provinces should enhance the enabling effect of new infrastructure on the regional 'innovation-ecology-economy' coupling coordination by increasing new infrastructure investment, promote the formation of a linkage mechanism for new infrastructure empowerment, and open up the transmission path of new infrastructure so as to achieve high-quality and sustainable regional development in the new era of China. [ABSTRACT FROM AUTHOR]