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Background: Quercetin is a flavonoid having anti-cancer properties; however, it has low stability, insufficient bioavailability, and poor solubility. This study aimed to load quercetin on nanoliposomes to enhance its efficiency against SW48 colorectal cancer cells. The cytotoxicity of free-quercetin and quercetin-loaded nanoliposomes on the expression of the epidermal growth factor receptor (EGER) gene was investigated. Methods: This present in vitro study was conducted at Yasuj University of Medical Sciences (Yasuj, Iran) in 2021. In this in vitro study, the lipid thin-film hydration method was used to synthesize quercetin-loaded liposomes. Additionally, high-performance liquid chromatography (HPLC) analyses, dynamic light scattering (DLS), and transmission electron microscopy (TEM) investigations were used to characterize nanomaterials. Following that, MTT, flow cytometry, and real-time PCR were used to investigate the cytotoxicity of quercetin-loaded liposomes on the colorectal cancer cells SW48 cell line, the incidence of apoptosis, and the expression of the EGFR gene in these cells. Statistical analysis was performed using the SPSS (version 26.0), and the graphs were created with the GraphPad Prism version 8.4.3. P<0.05 was considered statistically significant. Results: The nanoparticles were spherical, homogenous, and 150±10 nm in size. According to HPLC, Quercetin had a 98% loading capacity. Although both free quercetin and quercetin-loaded liposomes indicated significant cytotoxicity against cancer cells (P<0.001), the combined form was significantly more active (P=0.008). 50 µg/mL of this compound reduced the viability of SW48 cells by more than 80% (IC50: 10.65 µg/mL), while the viability of cells treated with free quercetin was only 66% (IC50: 18.74 µg/mL). The apoptosis was nearly doubled in the cells treated with quercetin-loaded nanoliposomes compared to free quercetin (54.8% versus 27.6%). EGFR gene expression, on the other hand, was significantly lower in cells treated with quercetin-loaded liposomes than the quercetin alone (P=0.006). Conclusion: When combined with nanoliposomes, quercetin had greater anti-proliferative, apoptotic, and anti-EGFR expression than free quercetin. [ABSTRACT FROM AUTHOR]

Statement of the Problem: Streptococcus mutans, Streptococcus sanguinis, and Streptococcus salivarius are most common etiologic bacteria for dental caries. Different sizes of gold nanoparticles may have different antibacterial effects on these species. Purpose: This study aimed to compare the antibacterial effect of chlorhexidine and three sizes of gold nano particles (25, 60, 90nm) against clinical and standard strains of Streptococcus mutans, Streptococcus sanguinis, and Streptococcus salivarius. Materials and Method: In this cross-sectional study, the specimens were collected from 75 children aged 3-5 years old. Antibacterial effect of chlorhexidine and three sizes of gold nano particles (25, 60, 90nm) were investigated by evaluating the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against three bacterial strains. Results: The MIC and MBC of gold nanoparticles with different sizes against Streptococcus mutans, Streptococcus sanguinis, and Streptococcus salivarius were statistically different. The MIC and MBC of smaller gold nano particles (25nm) were significantly lower (p<0.001) than larger ones. Patient-derived bacteria had significantly higher values of MIC and MBC in comparison to standard species (p<0.001). Conclusion: The results of this study confirmed the significant size-dependency of gold nano particles for antibacterial activity. As the size of gold nano particles decrease, the antibacterial properties enhance. [ABSTRACT FROM AUTHOR]

Background: Pre-eclampsia is a major cause of maternal and perinatal mortality and morbidity, especially in low-income and middle-income countries One way to manage this disease is to use Mobile Health. Objective: The purpose of this study is to systematically investigate the effectiveness of mHealth in the management of Preeclampsia. Material and Methods: A search was performed using the main keywords " Mobile Health ", and " Preeclampsia " and their synonyms in Web of Science, PubMed, and Scopus databases until September 9, 2022. The original articles published in English that dealt with the " effect of using mHealth on the Management of patients with Preeclampsia " were included in the study and their characteristics were examined. Results: Finally, 7 articles were included from the 308 articles found in the initial search stage, which examined patients' management using mobile health. Five studies (71.42%) considered mobile health to be effective in increasing blood pressure control. Other studies also found the use of mobile health in Diagnosis and prognosis (n=1) and Reduction of preeclampsia (n=1) were considered effective. Also, some studies showed that the use of mobile health for blood pressure and symptom monitoring in antenatal care for high-risk women is associated with lower costs compared to conventional care. Conclusion: The use of mobile health effectively controls the disease and promotes management in Preeclampsia patients. It is suggested that mobile health tools and capabilities be used more widely in providing services to the community with Preeclampsia. [ABSTRACT FROM AUTHOR]

Background: To protect pregnant mothers from infection during the COVID pandemic, health care providers turned to mHealth to provide as much prenatal care as possible. Objective: This survey was conducted to evaluate mother's experience with a prenatal m-health care and identify benefit to accessing mHealth among urban and rural pregnant mothers in Qom province during of the COVID-19 pandemic. Material and Methods: Due to the COVID-19 pandemic, on July, 2020, inmother routine prenatal care was abruptly converted to a hybrid model at health care. Approximately half of routine visits were scheduled via mHealth utilizing either audioonly platforms through cell phones or landlines. In-person visits were planned only with high risk pregnant mothers. A qualitative study using semi structured interviews was conducted of 12 pregnant mother who had successfully participated in a mHealth visit with a midwifery provider early in the course of the COVID-19 pandemic. Results: Three main themes and ten sub-themes affecting access to healthcare services were identified: Virtual care (phone visit, telephone follow-up, continuity of care at home), Self-care efficacy (mother engagement, encourage self-help skills, the ability of self-care), The Cost Effectiveness of Prenatal Care (cost reduction health care, reduce unnecessary procedure, time saving) was achieved. Conclusion: As our findings show, there was a strong benefit with respect to interoperability in mHealth. Health systems should recognize that mHealth can only fulfill its promise if all mothers pregnant have fair access to the tools necessary for participation. [ABSTRACT FROM AUTHOR]