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Depression is the leading cause of global disability, and many patients fail to respond to standard treatments. Preliminary evidence suggests that adjunctive nutrition therapy may improve treatment outcomes in depression. We review the evidence for the efficacy and/or mechanisms of the following nutrients: vitamin D, vitamins B12 and B9, vitamin C, zinc, selenium, omega-3 fatty acid, N-acetylcysteine, and nicotinamide riboside. Preliminary evidence suggests that these nutrients may facilitate mood regulation by regulating neurotransmitters, engaging in reduction-oxidation, or by modulating neuronal structure. Although initial evidence is promising, large, placebo-controlled studies are needed to validate their efficacy. [ Psychiatr Ann. 2019;49(1):21–25.]

[...]we have a body of laws that tell people what they can and cannot do—such as wearing seatbelts, driving while intoxicated, or stopping at a red light, just to name a few examples. [...]as the recently passed abortion law in Texas and anti-voting laws that disproportionately affect people of color have shown, white men want to retain their power to control women's bodies and disenfranchise people of color. 10.1177/15248399211016463 PMID: 33966471 Andrew A. Nierenberg, MD, holds the Thomas P. Hackett, MD, Endowed Chair in Psychiatry at MGH, and is the Director of the Dauten Family Center for Bipolar Treatment Innovation, and the Director, Center for Clinical Research Education, MGH Research Institute, Massachusetts General Hospital;and a Professor of Psychiatry, Harvard Medical School.

Motivation is fueled by keeping in mind some future goal and predicting a desirable outcome worth expending effort for 2,3 We continuously ask ourselves and compute, “Is the anticipated reward worth the cost?” Do we pursue a high cost/high reward or a low cost/low reward strategy? Treadway MT, Buckholtz JW, Cowan RL Dopaminergic mechanisms of individual differences in human effort-based decision-making JNeurosci 2012;32(18): 6170–6176 PLoS One 2009;4(8): e6598 10 1371/journal pone 0006598 Andrew A Nierenberg, MD, is the Thomas P Hackett, MD, Endowed Chair in Psychiatry, the Director of the Dauten Family Center for Bipolar Treatment Innovation, and the Co-Director, Center for Clinical Research Education, Massachusetts General Hospital;and a Professor of Psychiatry, Harvard Medical School