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1. [Differentiation of the stimulating action of adrenaline and noradrenaline on oxygen consumption of the parotid gland in the rat].

Author

Terzic M and Stojic D

Subjects
Animals, Epinephrine antagonists & inhibitors, Norepinephrine antagonists & inhibitors, Parotid Gland drug effects, Phentolamine pharmacology, Propranolol pharmacology, Rats, Yohimbine pharmacology, Epinephrine pharmacokinetics, Norepinephrine pharmacokinetics, Oxygen Consumption drug effects, Parotid Gland metabolism
Abstract

Epinephrine and norepinephrine, but not isoproterenol, stimulated the consumption of oxygen in rat parotid gland slices in a dose dependent manner. Their actions were abolished by phentolamine but propranolol had no effect. The response to epinephrine was selectively blocked by yohimbine, whereas the response to norepinephrine was inhibited by prazosin. Nifedipine abolished the action of epinephrine but had no effect on norepinephrine. The findings suggest that epinephrine enhanced oxygen consumption in the parotid gland slices by the activation of the calcium dependent alpha-2-adrenoreceptors while the response to norepinephrine was mediated by the alpha-1-receptors.

Published
1987

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