1. Efficacy of the 7-chloro-4-(3-hydroxy-benzilidenehydrazo)quinoline derivative against infection caused by Leishmania amazonensis
- Author
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Luciana Maria Ribeiro Antinarelli, Marcus Vinicius Nora de Souza, Eduardo Antonio Ferraz Coelho, Wallace Pacienza Lima, and Elaine Soares Coimbra
- Subjects
Leishmania amazonensis ,Quinoline ,Chemotherapy ,Cutaneous leishmaniasis ,Toxicity ,Arctic medicine. Tropical medicine ,RC955-962 - Abstract
Abstract INTRODUCTION: The drugs currently available for leishmaniasis treatment have major limitations. METHODS: In vitro and in vivo studies were performed to evaluate the effect of a quinoline derivative, Hydraqui (7-chloro-4-(3-hydroxy-benzilidenehydrazo)quinoline, against Leishmania amazonensis. In silico analyses of absorption, distribution, metabolism, excretion, and toxicity (ADMET) parameters were performed. RESULTS: Hydraqui showed significant in vitro anti-amastigote activity. Also, Hydraqui-treated mice exhibited high efficacy in lesion size (48.3%) and parasitic load (93.8%) reduction, did not cause hepatic and renal toxicity, and showed appropriate ADMET properties. CONCLUSIONS: Hydraqui presents a set of satisfactory criteria for its application as an antileishmanial agent. more...
- Published
- 2020
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