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Your search keyword '"L. Morrone"' showing total 4 results
Start Over Author "L. Morrone" Publisher societa italiana di nefrologia
4 results on '"L. Morrone"'

1. [Update 2017 of the KDIGO guidelines on Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). What are the real changes?]

Author

Pasquali M, Bellasi A, Cianciolo G, Massimetti C, Mereu MC, Morrone L, and Panuccio V

Subjects
Adrenal Cortex Hormones adverse effects, Biopsy, Bone Demineralization, Pathologic etiology, Bone Demineralization, Pathologic physiopathology, Bone Demineralization, Pathologic therapy, Bone Density, Bone Density Conservation Agents therapeutic use, Bone Resorption etiology, Bone Resorption prevention & control, Bone and Bones pathology, Calcium analysis, Contraindications, Drug, Dialysis Solutions chemistry, Humans, Hypercalcemia etiology, Hypercalcemia prevention & control, Hypercalcemia therapy, Hyperparathyroidism, Secondary drug therapy, Hyperparathyroidism, Secondary etiology, Hyperparathyroidism, Secondary physiopathology, Hyperphosphatemia diet therapy, Hyperphosphatemia drug therapy, Hyperphosphatemia etiology, Renal Insufficiency, Chronic complications, Renal Insufficiency, Chronic metabolism, Vitamin D therapeutic use, Chronic Kidney Disease-Mineral and Bone Disorder diagnostic imaging, Chronic Kidney Disease-Mineral and Bone Disorder physiopathology, Chronic Kidney Disease-Mineral and Bone Disorder therapy
Abstract

Guidelines for the assessment, diagnosis and therapy of the alterations that characterize the CKD-MBD are an important support in the clinical practice of the nephrologist. Compared to the KDIGO guidelines published in 2009, the 2017 update made changes on some topics on which there was previously no strong evidence both in terms of diagnosis and therapy. The recommendations include the diagnosis of bone anomalies in CKD-MBD and the treatment of mineral metabolism abnormalities with particular regard to hyperphosphataemia, calcium levels, secondary hyperparathyroidism and anti-resorptive therapies. The Italian Study Group on Mineral Metabolism, in reviewing the 2017 recommendations, aimed to assess the weight of the evidence that led to this update. In fact, on some topics there has not been a substantial difference on the degree of evidence compared to the previous guidelines. The Italian Study Group emphasizes the points that may still reserve critical issues, including interpretation, and invites an evaluation that is articulated and personalized for each patient., (Copyright by Società Italiana di Nefrologia SIN, Rome, Italy.)

Published
2018

2. [ASSOCIATION BETWEEN VERTEBRAL FRACTURES AND VASCULAR CALCIFICATIONS].

Author

Piscopo G and Morrone L

Subjects
Aged, Aged, 80 and over, Cardiovascular Diseases epidemiology, Causality, Chronic Kidney Disease-Mineral and Bone Disorder etiology, Comorbidity, Cross-Sectional Studies, Female, Fractures, Spontaneous etiology, Humans, Kidney Transplantation, Male, Metabolic Syndrome complications, Middle Aged, Multicenter Studies as Topic, Osteoporosis epidemiology, Prospective Studies, Renal Dialysis adverse effects, Renal Insufficiency, Chronic therapy, Risk, Spinal Fractures etiology, Aortic Diseases epidemiology, Calcinosis epidemiology, Fractures, Spontaneous epidemiology, Renal Insufficiency, Chronic epidemiology, Spinal Fractures epidemiology
Abstract

Several cross-sectional and prospective studies highlight the existence of an association between bone fractures and abdominal aortic calcifications, especially if particularly severe and independent from confounders such as aging, smoking habits and diabetes. This phenomenon affects not only the general population but also patients with chronic kidney disease in which cortical bone lesions are prevalent. Moreover, bone fractures and aortic calcifications have been proved to be linked to increased cardiovascular morbidity and mortality, both in the general populations and in patients with chronic kidney disease, who notoriously show elevated cardiovascular risks. Therefore, diagnostic investigations about bone fractures and abdominal aortic calcifications, particularly in patients with chronic kidney disease, may represent a useful tool for identification of patients with a higher cardiovascular risk in order to optimize therapies for bone metabolism disorders., (Copyright by Società Italiana di Nefrologia SIN, Rome, Italy.)

Published
2017

3. [A dangerous loop].

Author

Salvatore E, Diglio A, Stellato D, Aversano A, Liuzzi M, and Morrone L

Subjects
Humans, Male, Radiography, Renal Veins diagnostic imaging, Rupture, Spontaneous, Varicose Veins diagnostic imaging, Young Adult, Hematuria etiology, Renal Veins abnormalities, Varicose Veins complications
Published
2012

4. [Diverse histological lesions in a patient with antiphospholipid syndrome (APS)].

Author

Salvatore E, Luciani R, Di Palma A, Aversano A, Stellato D, Liuzzi M, Iele E, Martignetti V, Spagnuolo E, and Morrone L

Subjects
Antiphospholipid Syndrome complications, Biopsy, Edema etiology, Glomerulosclerosis, Focal Segmental pathology, Humans, Male, Middle Aged, Proteinuria etiology, Thrombosis pathology, Antiphospholipid Syndrome pathology, Glomerulosclerosis, Focal Segmental etiology, Kidney Glomerulus pathology, Thrombosis etiology
Abstract

Antiphospholipid syndrome (APS) is a rare autoimmune disorder. It can be secondary to systemic lupus erythematosus (SLE) or occur in the absence of autoimmune disease. The hallmark of this so-called primary APS is the presence of circulating antiphospholipid antibodies. Renal involvement in primary APS is caused by thrombosis within the renal vasculature. Recently, nonthrombotic glomerulonephritic renal lesions have been described in primary APS as a new histological entity. We here report a patient with primary APS in whom both lesion types were present. A 58-year-old Caucasian man with no significant past medical history presented to our nephrology unit with diffuse edema. Urinalysis showed proteinuria exceeding 400 mg/dL. The autoantibody panel (p-ANCA, c- ANCA, anti-nucleus, anti-DS-DNA) was negative except for anticardiolipin antibodies, which tested positive in two different samples. The diagnostic workup included a kidney biopsy that revealed thrombotic lesions compatible with primary APS and a typical pattern of focal segmental glomerulosclerosis. The kidney is a major target in APS but the exact mechanism underlying the pathogenesis of APS nephropathy has been poorly recognized. The use of kidney biopsy is a fundamental diagnostic tool in this setting, with possible implications also from a prognostic and therapeutic viewpoint.

Published
2011

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