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This article examines the effects of pretreating dentin with a 2% chlorhexidine solution and subjecting it to cariogenic attack on the marginal adaptation of glass ionomer cement (GIC) to dentin walls. The study found that pretreatment with chlorhexidine did not significantly affect the marginal adaptation of GIC to dentin, but cariogenic attack did have a negative impact on the interface between the material and dentin. The study emphasizes the need for further validation through in vitro and in vivo studies and provides insights for the use of GIC. [Extracted from the article]