1. Hippocampal function in healthy carriers of the CLU Alzheimer's disease risk variant.
- Author
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Erk S, Meyer-Lindenberg A, Opitz von Boberfeld C, Esslinger C, Schnell K, Kirsch P, Mattheisen M, Mühleisen TW, Cichon S, Witt SH, Rietschel M, Nöthen MM, and Walter H
- Subjects
- Adult, Brain Mapping, Female, Genome-Wide Association Study, Genotype, Hippocampus blood supply, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Oxygen blood, Prefrontal Cortex, Young Adult, Clusterin genetics, Genetic Predisposition to Disease, Hippocampus physiopathology, Memory physiology, Polymorphism, Single Nucleotide genetics
- Abstract
Alzheimer's disease is a devastating, common, progressive dementia with considerable heritability. Recently, a genetic variant associated with the disease was discovered at CLU (rs11136000) with genome-wide support. Here we show, using an imaging genetics approach in a large genotyped sample, that healthy carriers of the variant exhibit altered coupling between hippocampus and prefrontal cortex during memory processing, mirroring clinical evidence of disturbed connectivity in patients and providing a neurogenetic mechanism for CLU-associated risk and protection.
- Published
- 2011
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