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Your search keyword '"MESH: Brain Mapping"' showing total 4 results
Start Over Descriptor "MESH: Brain Mapping" Publisher society for neuroscience
4 results on '"MESH: Brain Mapping"'

1. Dynamic Causal Modeling of Spatiotemporal Integration of Phonological and Semantic Processes: An Electroencephalographic Study

Author

Monica Baciu, Marcela Perrone-Bertolotti, Gaëtan Yvert, Olivier David, INSERM U836, équipe 11, Fonctions cérébrales et neuromodulation, Laboratoire de Psychologie et NeuroCognition (LPNC), Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Clinique de Neuroradiologie et Unité IRM, CHU Grenoble-CHU Grenoble, and Région Rhône-Alpes

Subjects
Male, Electroencephalography, Brain mapping, MESH: Semantics, MESH: Magnetic Resonance Imaging, 0302 clinical medicine, Image Processing, Computer-Assisted, Temporal dynamics of music and language, Semantic memory, Evoked Potentials, MESH: Brain Mapping, Cerebral Cortex, Brain Mapping, medicine.diagnostic_test, General Neuroscience, 05 social sciences, Magnetic Resonance Imaging, MESH: Image Processing, Computer-Assisted, Semantics, MESH: Nonlinear Dynamics, MESH: Evoked Potentials, MESH: Photic Stimulation, medicine.anatomical_structure, MESH: Young Adult, Cerebral cortex, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Psychology, Cognitive psychology, Adult, MESH: Phonetics, Models, Neurological, Inferior frontal gyrus, Article, 050105 experimental psychology, Temporal lobe, Young Adult, 03 medical and health sciences, Phonetics, MESH: Models, Neurological, MESH: Electroencephalography, Reaction Time, medicine, Humans, 0501 psychology and cognitive sciences, MESH: Humans, MESH: Adult, MESH: Cerebral Cortex, MESH: Male, MESH: Reaction Time, Nonlinear Dynamics, MESH: Female, Neuroscience, Photic Stimulation, 030217 neurology & neurosurgery
Abstract

International audience; Integration of phonological and lexicosemantic processes is essential for visual word recognition. Here we used dynamic causal modeling of event-related potentials, combined with group source reconstruction, to estimate how those processes translate into context-dependent modulation of effective connectivity within the temporal-frontal language network. Fifteen healthy human subjects performed a phoneme detection task in pseudo-words and a semantic categorization task in words. Cortical current densities revealed the sequential activation of temporal regions, from the occipital-temporal junction toward the anterior temporal lobe, before reaching the inferior frontal gyrus. A difference of activation between phonology and semantics was identified in the anterior temporal lobe within the 240-300 ms peristimulus time window. Dynamic causal modeling indicated this increase of activation of the anterior temporal lobe in the semantic condition as a consequence of an increase of forward connectivity from the posterior inferior temporal lobe to the anterior temporal lobe. In addition, fast activation of the inferior frontal region, which allowed a feedback control of frontal regions on the superior temporal and posterior inferior temporal cortices, was found to be likely. Our results precisely describe spatiotemporal network mechanisms occurring during integration of phonological and semantic processes. In particular, they support the hypothesis of multiple pathways within the temporal lobe for language processing, where frontal regions would exert a top-down control on temporal regions in the recruitment of the anterior temporal lobe for semantic processing.

Published
2012
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2. Microstructural Correlates of Infant Functional Development: Example of the Visual Pathways

Author

Catherine Soares, Lucie Hertz-Pannier, Ghislaine Dehaene-Lambertz, Y. Cointepas, Denis Le Bihan, Jessica Dubois, Institut de recherche en cancérologie de Montpellier (IRCM - U896 Inserm - UM1), CRLCC Val d'Aurelle - Paul Lamarque-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 1 (UM1), Département de radiothérapie, CRLCC Val d'Aurelle - Paul Lamarque, Service NEUROSPIN (NEUROSPIN), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut d'imagerie neurofonctionnelle (IIN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Ecole Nationale Supérieure des Télécommunications (ENST)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École des hautes études en sciences sociales (EHESS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Neuroimagerie cognitive (LCogn), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Traitement et Communication de l'Information (LTCI), Télécom ParisTech-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS), Human Brain Research Center [Kyoto] (HBRC), Kyoto University [Kyoto], IFR de Neuroimagerie Fonctionnelle (IFR 49), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Service Hospitalier Frédéric Joliot (SHFJ), National Institutes of Health [Bethesda] (NIH), Université Montpellier 1 (UM1)-CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-École des hautes études en sciences sociales (EHESS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Ecole Nationale Supérieure des Télécommunications (ENST)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Kyoto University, and Le Bihan, Denis

Subjects
Physiological significance, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Neural Conduction, MESH: Diffusion Magnetic Resonance Imaging, Visual system, 050105 experimental psychology, White matter, 03 medical and health sciences, [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics, Child Development, 0302 clinical medicine, MESH: Neural Conduction, Fractional anisotropy, medicine, Humans, Visual Pathways, 0501 psychology and cognitive sciences, MESH: Neuronal Plasticity, MESH: Brain Mapping, MESH: Child Development, Brain Mapping, MESH: Visual Pathways, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, Neuronal Plasticity, MESH: Humans, [SCCO.NEUR]Cognitive science/Neuroscience, General Neuroscience, [SCCO.NEUR] Cognitive science/Neuroscience, MESH: Infant, Newborn, 05 social sciences, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Infant, Newborn, Infant, Cognition, MESH: Infant, Functional development, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, Diffusion Magnetic Resonance Imaging, MESH: Photic Stimulation, medicine.anatomical_structure, nervous system, Brief Communications, Psychology, Neuroscience, Photic Stimulation, 030217 neurology & neurosurgery, Diffusion MRI, Tractography
Abstract

The development of cognitive functions during childhood relies on several neuroanatomical maturation processes. Among these processes is myelination of the white matter pathways, which speeds up electrical conduction. Quantitative indices of such structural processes can be obtainedin vivowith diffusion tensor imaging (DTI), but their physiological significance remains uncertain. Here, we investigated the microstructural correlates of early functional development by combining DTI and visual event-related potentials (VEPs) in 15 one- to 4-month-old healthy infants. Interindividual variations of the apparent conduction speed, computed from the latency of the first positive VEP wave (P1), were significantly correlated with the infants' age and DTI indices measured in the optic radiations. This demonstrates that fractional anisotropy and transverse diffusivity are structural markers of functionally efficient myelination. Moreover, these indices computed along the optic radiations showed an early wave of maturation in the anterior region, with the posterior region catching up later in development, which suggests two asynchronous fronts of myelination in both the geniculocortical and corticogeniculate fibers. Thus, in addition to microstructural information, DTI provides noninvasive exquisite information on the functional development of the brain in human infants.

Published
2008
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3. Deep Layer Somatosensory Cortical Neurons Initiate Spike-and-Wave Discharges in a Genetic Model of Absence Seizures

Author

Pierre-Olivier Polack, Emilie Hu, Antoine Depaulis, Isabelle Guillemain, Colin Deransart, Stéphane Charpier, Dynamique et physiopathologie des réseaux neuronaux, Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Labex MemoLife, Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Collaboration, Deransart, Colin, Centre interdisciplinaire de recherche en biologie (CIRB), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), and Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)

Subjects
Periodicity, MESH: Periodicity, [SDV]Life Sciences [q-bio], MESH: Neurons, Action Potentials, Somatosensory system, Epilepsy, 0302 clinical medicine, MESH: Animals, MESH: Models, Genetic, MESH: Action Potentials, MESH: Brain Mapping, MESH: Epilepsy, Absence, Neurons, Brain Mapping, 0303 health sciences, General Neuroscience, Articles, [SDV] Life Sciences [q-bio], medicine.anatomical_structure, Cerebral cortex, Psychology, MESH: Face, Cortical Synchronization, MESH: Rats, Thalamus, Biotin, MESH: Somatosensory Cortex, 03 medical and health sciences, MESH: Analysis of Variance, MESH: Biotin, Genetic model, medicine, Animals, Ictal, Rats, Wistar, Wakefulness, 030304 developmental biology, Analysis of Variance, Models, Genetic, Spike-and-wave, Somatosensory Cortex, MESH: Rats, Wistar, medicine.disease, Rats, MESH: Wakefulness, Epilepsy, Absence, Face, Neuroscience, 030217 neurology & neurosurgery
Abstract

International audience; Typical absence has long been considered as the prototypic form of generalized nonconvulsive epileptic seizures. Recent investigations in patients and animal models suggest that absence seizures could originate from restricted regions of the cerebral cortex. However, the cellular and local network processes of seizure initiation remain unknown. Here, we show that absence seizures in Genetic Absence Epilepsy Rats from Strasbourg, a well established genetic model of this disease, arise from the facial somatosensory cortex. Using in vivo intracellular recordings, we found that epileptic discharges are initiated in layer 5/6 neurons of this cortical region. These neurons, which show a distinctive hyperactivity associated with a membrane depolarization, lead the firing of distant cortical cells during the epileptic discharge. Consistent with their ictogenic properties, neurons from this "focus" exhibit interictal and preictal oscillations that are converted into epileptic pattern. These results confirm and extend the "focal hypothesis" of absence epilepsy and provide a cellular scenario for the initiation and generalization of absence seizures.

Published
2007
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4. Altered Map of Visual Space in the Superior Colliculus of Mice Lacking Early Retinal Waves

Author

Sonja B. Hofer, Isabelle Cloëz-Tayarani, Tobias Bonhoeffer, Mark Hübener, Jean-Pierre Changeux, Thomas D. Mrsic-Flogel, Claire Creutzfeldt, Max-Planck-Institut für Neurobiologie (MPIN), Max-Planck-Gesellschaft, Récepteurs et Cognition (RC), Collège de France (CdF (institution))-Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), and Collège de France (CdF (institution))-Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Retinal Ganglion Cells, Superior Colliculi, MESH: Mice, Mutant Strains, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Visual space, Development/Plasticity/Repair, Receptors, Nicotinic, Visual system, Biology, Retinal ganglion, Retina, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, MESH: Mice, Inbred C57BL, medicine, Animals, Visual Pathways, MESH: Animals, MESH: Mice, MESH: Brain Mapping, 030304 developmental biology, Brain Mapping, MESH: Visual Pathways, 0303 health sciences, MESH: Retina, General Neuroscience, Superior colliculus, MESH: Superior Colliculi, MESH: Retinal Ganglion Cells, Retinal, Mice, Mutant Strains, Retinal waves, Mice, Inbred C57BL, medicine.anatomical_structure, chemistry, MESH: Receptors, Nicotinic, Axon guidance, Neuroscience, 030217 neurology & neurosurgery
Abstract

During the development of the mammalian retinocollicular projection, a coarse retinotopic map is set up by the graded distribution of axon guidance molecules. Subsequent refinement of the initially diffuse projection has been shown to depend on the spatially correlated firing of retinal ganglion cells. In this scheme, the abolition of patterned retinal activity is not expected to influence overall retinotopic organization, but this has not been investigated. We used optical imaging of intrinsic signals to visualize the complete retinotopic map in the superior colliculus (SC) of mice lacking early retinal waves, caused by the deletion of the β2 subunit of the nicotinic acetylcholine receptor. As expected from previous anatomical studies in the SC of β2-/-mice, regions activated by individual visual stimuli were much larger and had less sharp borders than those in wild-type mice. Importantly, however, we also found systematic distortions of the entire retinotopic map: the map of visual space was expanded anteriorly and compressed posteriorly. Thus, patterned neuronal activity in the early retina has a substantial influence on the coarse retinotopic organization of the SC.

Published
2005
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