1. Estradiol improves cerebellar memory formation by activating estrogen receptor beta
- Author
-
Piet Kramer, Elize D. Haasdijk, Frank H. de Jong, Bogdan A. Milojkovic, Andrée Krust, Marcel T. G. De Jeu, Corina E. Andreescu, Chris I. De Zeeuw, Pathology/molecular and cellular medicine, Diabetes Clinic, Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Louis Pasteur - Strasbourg I
- Subjects
Male ,Cerebellum ,Patch-Clamp Techniques ,Motor Activity/genetics ,Time Factors ,Memory/drug effects ,Endocrinology, Diabetes and Metabolism ,Purkinje cell ,Long-Term Potentiation ,MESH: Mice, Knockout ,Purkinje Cells ,0302 clinical medicine ,Nerve Fibers ,MESH: Behavior, Animal ,MESH: Animals ,MESH: Memory ,Electric Stimulation/methods ,Mice, Knockout ,0303 health sciences ,MESH: Estrogen Receptor beta ,Estradiol ,Behavior, Animal ,General Neuroscience ,MESH: Electric Stimulation ,Long-term potentiation ,MESH: Neural Inhibition ,Climbing fiber ,Articles ,Reflex, Vestibulo-Ocular ,Nerve Fibers/physiology ,MESH: Motor Activity ,Ovariectomy/methods ,medicine.anatomical_structure ,Cerebellar cortex ,Female ,MESH: Estradiol ,Motor learning ,Psychology ,hormones, hormone substitutes, and hormone antagonists ,mice ,medicine.drug_class ,Patch-Clamp Techniques/methods ,Ovariectomy ,MESH: Ovariectomy ,Parallel fiber ,Motor Activity ,In Vitro Techniques ,Neural Inhibition/drug effects ,MESH: Reflex, Vestibulo-Ocular ,03 medical and health sciences ,MESH: Purkinje Cells ,MESH: Long-Term Potentiation ,Memory ,MESH: Analysis of Variance ,MESH: Patch-Clamp Techniques ,MESH: Dose-Response Relationship, Radiation ,Reflex, Vestibulo-Ocular/physiology ,medicine ,Estrogen Receptor beta ,Animals ,MESH: Mice ,MESH: Nerve Fibers ,030304 developmental biology ,Analysis of Variance ,Estrogen Receptor beta/deficiency ,MESH: Time Factors ,Neural Inhibition ,[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology ,Dose-Response Relationship, Radiation ,Cerebellum/cytology ,Electric Stimulation ,MESH: Male ,MESH: Cerebellum ,Estradiol/pharmacology ,Estrogen ,Purkinje Cells/drug effects ,Neuroscience ,MESH: Female ,Long-Term Potentiation/drug effects ,030217 neurology & neurosurgery - Abstract
Learning motor skills is critical for motor abilities such as driving a car or playing piano. The speed at which we learn those skills is subject to many factors. Yet, it is not known to what extent gonadal hormones can affect the achievement of accurate movements in time and space. Here we demonstrate via different lines of evidence that estradiol promotes plasticity in the cerebellar cortex underlying motor learning. First, we show that estradiol enhances induction of long-term potentiation at the parallel fiber to Purkinje cell synapse, whereas it does not affect long-term depression; second, we show that estradiol activation of estrogen receptor β receptors in Purkinje cells significantly improves gain-decrease adaptation of the vestibulo-ocular reflex, whereas it does not affect general eye movement performance; and third, we show that estradiol increases the density of parallel fiber to Purkinje cell synapses, whereas it does not affect the density of climbing fiber synapses. We conclude that estradiol can improve motor skills by potentiating cerebellar plasticity and synapse formation. These processes may be advantageous during periods of high estradiol levels of the estrous cycle or pregnancy.
- Published
- 2007
- Full Text
- View/download PDF