1. Hippocampal Function in Healthy Carriers of the CLU Alzheimer's Disease Risk Variant.
- Author
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Erk, Susanne, Meyer-Lindenberg, Andreas, von Boberfeld, Carola Opitz, Esslinger, Christine, Schnell, Knut, Kirsch, Peter, Mattheisen, Manuel, Mühleisen, Thomas W., Cichon, Sven, Witt, Stephanie H., Rietschel, Marcella, Nöthen, Markus M., and Walter, Henrik
- Subjects
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HIPPOCAMPUS (Brain) , *BRAIN function localization , *ALZHEIMER'S disease , *DISEASE progression , *PREFRONTAL cortex , *CLINICAL trials , *MEMORY - Abstract
Alzheimer's disease is a devastating, common, progressive dementia with considerable heritability. Recently, a genetic variant associated with the disease was discovered at CLU (rs11136000) with genome-wide support. Here we show, using an imaging genetics approach in a large genotyped sample, that healthy carriers of the variant exhibit altered coupling between hippocampus and prefrontal cortex during memory processing, mirroring clinical evidence of disturbed connectivity in patients and providing a neurogenetic mechanism for CLU-associated risk and protection. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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