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Objective: The aim of this study was to evaluate the antiradical and inhibitory activity of whole plant extracts of Phyllanthus amarus and Striga hermonthica on α-amylase. Methods: The crude 70% (v/v) hydroethanolic extracts obtained were used for the assay of polyphenols, the antiradical test with DPPH, the test for the inhibition of α-amylase with DNS (3,5-dinitrosalicylic). The enzyme extracts were obtained from sorghum malt (Sorghum bicolor). Results: It appears from this study that the extract of P. amarus was richer in polyphenols than the extract of S. hermonthica. Regarding the antiradical activity, the extract of S. hermonthica showed an IC50 of 339.06 ± 1.43 µg/mL against 77.74 ±2.73 µg/mL for the extract of P. amarus. Regarding the anti α-amylase activity, the extract of P. amarus inhibited IMS127 and KMTC 274 respectively 43.64 ±0.59% and 66.28 ±1.97%. On the other hand, the extract of S. hermonthica presented an inhibition of 3.93 ±0.91% on IMS127 and 14.85 ±1.62% on KMTC 274. The extract of P. amarus presents a good antiradical activity and anti α-amylase compared to S. hermonthica extract. In conclusion, these results partly explain the use of these plants in traditional medicine to treat or relieve people suffering from diabetes. Keywords : α-amylase, inhibition, polyphenols, antiradical, diabetes