1. Sclerostin is a possible candidate marker of arterial stiffness: Results from a cohort study in Catania
- Author
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Carmelo Erio Fiore, Luca Zanoli, Salvatore Santo Signorelli, Giovanni Tringali, Maria Helga Sidoti, Valerio Fiore, Antonino Catalano, Rosario Rapisarda, Agostino Gaudio, and Anastasia Xourafa
- Subjects
Male ,Cancer Research ,Osteoporosis ,030204 cardiovascular system & hematology ,Carotid Intima-Media Thickness ,Biochemistry ,Cohort Studies ,chemistry.chemical_compound ,0302 clinical medicine ,Bayesian multivariate linear regression ,Medicine ,Ultrasonography ,education.field_of_study ,Confounding ,Middle Aged ,Augmentation index, CIMT, Dkk1, Pulse wave velocity, Sclerostin ,Carotid Arteries ,Oncology ,Bone Morphogenetic Proteins ,Cardiology ,Intercellular Signaling Peptides and Proteins ,Molecular Medicine ,Female ,Cohort study ,Genetic Markers ,medicine.medical_specialty ,Sclerostin ,Population ,030209 endocrinology & metabolism ,Pulse Wave Analysis ,03 medical and health sciences ,Vascular Stiffness ,Internal medicine ,Genetics ,Humans ,education ,Molecular Biology ,Adaptor Proteins, Signal Transducing ,Aged ,Dkk1 ,business.industry ,CIMT ,Augmentation index ,Atherosclerosis ,medicine.disease ,Pulse wave velocity ,Endocrinology ,chemistry ,DKK1 ,Linear Models ,Arterial stiffness ,business ,Biomarkers - Abstract
Osteoporosis and cardiovascular disease are worldwide public health issues. Recent evidence indicates a possible role of the canonical Wnt/β-catenin signalling pathway as a common mediator between these two diseases. The aim of the present study was to investigate the relationship between serum concentrations of sclerostin and Dkk1, two extracellular inhibitors of Wnt/β-catenin signalling, with carotid intima-media thickness (CIMT) and with arterial stiffness, evaluated by measuring the pulse wave velocity (PWV) in an ambulatory population of adults. To this aim, 67 subjects were recruited in the 'Atherosclerosis and osteoporosis: identification of common pathogenetic factors' investigation. Serum sclerostin levels correlated positively with CIMT (r=0.314, p=0.03) and inversely with the augmentation index, a marker of arterial stiffness (r=-0.286, p
- Published
- 2017
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