1. Involvement of macrophage migration inhibitory factor in cancer and novel therapeutic targets.
- Author
-
KINDT, NADÈGE, JOURNE, FABRICE, LAURENT, GUY, and SAUSSEZ, SVEN
- Subjects
MACROPHAGE migration inhibitory factor ,CANCER ,CYTOKINES ,IMMUNOLOGIC diseases ,RHEUMATOID arthritis ,CELL proliferation - Abstract
Macrophage migration inhibitory factor (MIF) was originally identified in 1966 by Bloom and Bennett as a pro-inflammatory cytokine involved in the inhibition of macrophage motility. Since then, studies have investigated the functional contribution of this pro-inflammatory cytokine in several immune diseases, including rheumatoid arthritis and lupus erythematous. Recently, MIF has been reported to be involved in a variety of neoplastic diseases. The present review discusses previous cancer research studies that have investigated the involvement of MIF in carcinogenesis, disease prognosis, tumor cell proliferation and invasion, and tumor-induced angiogenesis. Finally, potential therapeutic approaches based on the use of MIF antagonists and neutralizing antibodies are examined. The review concludes that MIF could be a good prognostic biomarker in several types of cancer, but also that the inhibition of MIF could represent a novel therapy against cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF