1. Trabecular bone class mapping across resolutions: translating methods from HR-pQCT to clinical CT
- Author
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Alexander Valentinitsch, Georg Langs, Lukas Fischer, Franz Kainberger, Matthew D. DiFranco, Janina M. Patsch, and Jan S. Bauer
- Subjects
Quantitative imaging ,medicine.diagnostic_test ,business.industry ,Osteoporosis ,Biomechanics ,medicine.disease ,Trabecular bone ,Cadaver ,Quantitative assessment ,Medicine ,Tibia ,Quantitative computed tomography ,business ,Nuclear medicine - Abstract
Quantitative assessment of 3D bone microarchitecture in high-resolution peripheral quantitative computed tomography (HR-pQCT) has shown promise in fracture risk assessment and biomechanics, but is limited to the distal radius and tibia. Trabecular microarchitecture classes (TMACs), based on voxel-wise clustering texture and structure tensor features in HRpQCT, is extended in this paper to quantify trabecular bone classes in clinical multi-detector CT (MDCT) images. Our comparison of TMACs in 12 cadaver radii imaged using both HRpQCT and MDCT yields a mean Dice score of up to 0.717±0.40 and visually concordant bone quality maps. Further work to develop clinically viable bone quantitative imaging using HR-pQCT validation could have a significant impact on overall bone health assessment.
- Published
- 2015
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