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21 results on '"Wang, Thomas D."'

3. Clinical application of a multi-modal endoscope with fluorescent peptide in detection of colorectal neoplasia (Conference Presentation)

Author

Dai, Zhenzhen, primary, Joshi, Bishnu P., additional, Gao, Zhenghong, additional, Lee, Jeonghoon, additional, Ghimire, Navin, additional, Prabhu, Anoop, additional, Wamsteker, Erik J., additional, Kwon, Richard S., additional, Elta, Grace H., additional, Appelman, Henry D., additional, Owens, Scott R., additional, Kuick, Rork, additional, Turgeon, Kim K., additional, and Wang, Thomas D., additional

Published
2017
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15. Compact optical design for dual-axes confocal endoscopic microscopes

Author

Mandella, Michael J., primary, Liu, Jonathan T. C., additional, Piyawattanametha, Wibool, additional, Ra, Hyejun, additional, Hsiung, Pei-Lin, additional, Wong, Larry K., additional, Solgaard, Olav, additional, Wang, Thomas D., additional, Contag, Christopher H., additional, and Kino, Gordon S., additional

Published
2007
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21. Low cost and compact nonlinear (SHG/TPE) laser scanning endoscope for bio-medical application

Author

Ying Zhang, Shaw Wei Kok, Hon Luen Seck, Hao Li, Jia Yun Liu, Xia Yu, Ken Choong Lim, Suter, Melissa J., Lam, Stephen, Brenner, Matthew, Tearney, Guillermo J., Wang, Thomas D., Endoscopic Microscopy X, and Optical Techniques in Pulmonary Medicine II, and A*STAR SIMTech

Subjects
Scanner, Materials science, Microscope, Laser scanning, business.industry, Second-harmonic generation, Nonlinear optics, Laser, law.invention, Nonlinear system, Optics, law, Science::Biological sciences::Microbiology [DRNTU], Fiber laser, Optoelectronics, business
Abstract

Two-photon fluorescence (TPE) and second harmonic generation (SHG) can been used to extract biological information from tissues at the molecular level, which is blind to traditional microscopes. Through these two image contrast mechanisms, a nonlinear laser scanning endoscope (NLSE) is able to image tissue cells and the extra cellular matrix (ECM) through a special fiber and miniaturized scanner without the requirement of poisonous chemical staining. Therefore, NLSE reserves high potential for in-vivo pathological study and disease diagnosis. However, the high cost and bulky size of a NLSE system has become one of the major issues preventing this technology from practical clinical operation. In this paper, we report a fiber laser based multi-modality NLSE system with compact size and low cost, ideal for in-vivo applications in clinical environments. The demonstration of the developed NLSE nonlinear imaging capability on different bio-structures in liver, retina and skin are also presented. Published version

Published
2015
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