1. Deep convolutional neural networks for molecular subtyping of gliomas using magnetic resonance imaging
- Author
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Dong Wei, Yiming Li, Yinyan Wang, Tianyi Qian, Yefeng Zheng, and Ziteng Liu
- Subjects
FOS: Computer and information sciences ,Training set ,medicine.diagnostic_test ,Receiver operating characteristic analysis ,business.industry ,Computer science ,Computer Vision and Pattern Recognition (cs.CV) ,Deep learning ,Image and Video Processing (eess.IV) ,Computer Science - Computer Vision and Pattern Recognition ,Pattern recognition ,Magnetic resonance imaging ,Electrical Engineering and Systems Science - Image and Video Processing ,Convolutional neural network ,World health ,Subtyping ,Radiomics ,FOS: Electrical engineering, electronic engineering, information engineering ,medicine ,Artificial intelligence ,business - Abstract
Knowledge of molecular subtypes of gliomas can provide valuable information for tailored therapies. This study aimed to investigate the use of deep convolutional neural networks (DCNNs) for noninvasive glioma subtyping with radiological imaging data according to the new taxonomy announced by the World Health Organization in 2016. Methods: A DCNN model was developed for the prediction of the five glioma subtypes based on a hierarchical classification paradigm. This model used three parallel, weight-sharing, deep residual learning networks to process 2.5-dimensional input of trimodal MRI data, including T1-weighted, T1-weighted with contrast enhancement, and T2-weighted images. A data set comprising 1,016 real patients was collected for evaluation of the developed DCNN model. The predictive performance was evaluated via the area under the curve (AUC) from the receiver operating characteristic analysis. For comparison, the performance of a radiomics-based approach was also evaluated. Results: The AUCs of the DCNN model for the four classification tasks in the hierarchical classification paradigm were 0.89, 0.89, 0.85, and 0.66, respectively, as compared to 0.85, 0.75, 0.67, and 0.59 of the radiomics approach. Conclusion: The results showed that the developed DCNN model can predict glioma subtypes with promising performance, given sufficient, non-ill-balanced training data., Comment: Proc. SPIE 11314, Medical Imaging 2020: Computer-Aided Diagnosis
- Published
- 2020