1. Increased Interleukin-8 in Epithelial Lining Fluid of Collapsed Lungs During One-Lung Ventilation for Thoracotomy
- Author
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Komatsu, Yoshimichi, Yamamoto, Hiroshi; HVnhHVkh, Tsushima, Kenji, Furuya, Shino, Yoshikawa, Sumiko, Yasuo, Masanori; ypnegpkh, Kubo, Keishi, Yamazaki, Yoshitaka, Hasegawa, Joh, Eguchi, Takashi; uVDpbhym, Kondo, Ryuichi, Yoshida, Kazuo, Koizumi, Tomonobu; WakmHhkh, Komatsu, Yoshimichi, Yamamoto, Hiroshi; HVnhHVkh, Tsushima, Kenji, Furuya, Shino, Yoshikawa, Sumiko, Yasuo, Masanori; ypnegpkh, Kubo, Keishi, Yamazaki, Yoshitaka, Hasegawa, Joh, Eguchi, Takashi; uVDpbhym, Kondo, Ryuichi, Yoshida, Kazuo, and Koizumi, Tomonobu; WakmHhkh
- Abstract
The present study was designed to evaluate inflammatory changes in collapsed lungs during one-lung ventilation using the assistance of a bronchoscopic microsampling probe. Serial albumin and interleukin (IL)-8 concentrations in epithelial lining fluid (ELF) were measured in seven patients undergoing resection of lung tumors. The samples were taken after induction of anesthesia (baseline), 30 min after one-lung ventilation was started (point 2), just before resuming two-lung ventilation (point 3), and 30 min after two-lung ventilation was restarted (point 4). The albumin and IL-8 concentrations in ELF were significantly increased at point 2 and point 3, respectively, and remained to be high, compared to the baseline. The increase in IL-8 at point 3 was correlated with the interval of one-lung ventilation; however, none developed specific acute lung injury. These findings suggest that inflammatory changes can occur on the epithelium of a collapsed lung even in patients who underwent successful and standard thoracic surgery.
- Published
- 2014