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1. Preliminary hemocompatibility assessment of an innovative material for blood contacting surfaces

Author

Martina Todesco, Elena Pontara, Chunyan Cheng, Gino Gerosa, Vittorio Pengo, and Andrea Bagno

Subjects
Materials of engineering and construction. Mechanics of materials, TA401-492, Medical technology, R855-855.5
Abstract

Abstract Over the years, several devices have been created (and the development of many others is currently in progress) to be in permanent contact with blood: mechanical circulatory supports represent an example thereof. The hemocompatibility of these devices largely depends on the chemical composition of blood-contacting components. In the present work, an innovative material (hybrid membrane) is proposed to fabricate the inner surfaces of a pulsatile ventricular chamber: it has been obtained by coupling a synthetic polymer (e.g., commercial polycarbonate urethane) with decellularized porcine pericardium. The hemocompatibility of the innovative material has been preliminarily assessed by measuring its capacity to promote thrombin generation and induce platelet activation. Our results demonstrated the blood compatibility of the proposed hybrid membrane.

Published
2021
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2. Preliminary hemocompatibility assessment of an innovative material for blood contacting surfaces

Author

Chun-Yan Cheng, Vittorio Pengo, Martina Todesco, Andrea Bagno, Elena Pontara, and Gino Gerosa

Subjects
Adult, Blood Platelets, Materials science, Polymers, Surface Properties, Swine, 0206 medical engineering, Biomedical Engineering, Biophysics, hybrid membrane, Bioengineering, 02 engineering and technology, Thrombin generation, Urethane, hemocompatibility, hybrid membrane, blood contacting surfaces, Biomaterials, Coated Materials, Biocompatible, Materials Testing, Medical technology, Animals, Humans, Platelet activation, Blood compatibility, R855-855.5, Materials of engineering and construction. Mechanics of materials, Decellularization, Polycarboxylate Cement, blood contacting surfaces, Thrombin, Membranes, Artificial, hemocompatibility, 021001 nanoscience & nanotechnology, Platelet Activation, 020601 biomedical engineering, Synthetic polymer, Membrane, Blood, Polycarbonate urethane, TA401-492, Female, Stress, Mechanical, 0210 nano-technology, Biocompatibility Studies, Pericardium, Biomedical engineering
Abstract

Over the years, several devices have been created (and the development of many others is currently in progress) to be in permanent contact with blood: mechanical circulatory supports represent an example thereof. The hemocompatibility of these devices largely depends on the chemical composition of blood-contacting components. In the present work, an innovative material (hybrid membrane) is proposed to fabricate the inner surfaces of a pulsatile ventricular chamber: it has been obtained by coupling a synthetic polymer (e.g., commercial polycarbonate urethane) with decellularized porcine pericardium. The hemocompatibility of the innovative material has been preliminarily assessed by measuring its capacity to promote thrombin generation and induce platelet activation. Our results demonstrated the blood compatibility of the proposed hybrid membrane.

Published
2021

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