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This review study presents the state-of-the-art machine and deep learning-based COVID-19 detection approaches utilizing the chest X-rays or computed tomography (CT) scans. This study aims to systematically scrutinize as well as to discourse challenges and limitations of the existing state-of-the-art research published in this domain from March 2020 to August 2021. This study also presents a comparative analysis of the performance of four majorly used deep transfer learning (DTL) models like VGG16, VGG19, ResNet50, and DenseNet over the COVID-19 local CT scans dataset and global chest X-ray dataset. A brief illustration of the majorly used chest X-ray and CT scan datasets of COVID-19 patients utilized in state-of-the-art COVID-19 detection approaches are also presented for future research. The research databases like IEEE Xplore, PubMed, and Web of Science are searched exhaustively for carrying out this survey. For the comparison analysis, four deep transfer learning models like VGG16, VGG19, ResNet50, and DenseNet are initially fine-tuned and trained using the augmented local CT scans and global chest X-ray dataset in order to observe their performance. This review study summarizes major findings like AI technique employed, type of classification performed, used datasets, results in terms of accuracy, specificity, sensitivity, F1 score, etc., along with the limitations, and future work for COVID-19 detection in tabular manner for conciseness. The performance analysis of the four majorly used deep transfer learning models affirms that Visual Geometry Group 19 (VGG19) model delivered the best performance over both COVID-19 local CT scans dataset and global chest X-ray dataset., Competing Interests: Conflict of InterestThe authors declare no competing interests., (© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)

The two most generally diagnosed Neurodegenerative diseases are the Alzheimer and Parkinson diseases. So this paper presents a fully automated early screening system based on the Capsule network for the classification of these two Neurodegenerative diseases. In this study, we hypothesized that the Neurodegenerative diseases-Caps system based on the Capsule network architecture accurately performs the multiclass i.e. three class classification into either the Alzheimer class or Parkinson class or Healthy control and delivers better results in comparison other deep transfer learning models. The real motivation behind choosing the capsule network architecture is its more resilient nature towards the affine transformations as well as rotational & translational invariance, which commonly persists in the medical image datasets. Apart from this, the capsule networks overcomes the pooling layers related deficiencies from which conventional CNNs are mostly affected and unable to delivers accurate results especially in the tasks related to image classification. The various Computer aided systems based on machine learning for the classification of brain tumors and other types of cancers are already available. Whereas for the classification of Neurodegenerative diseases, the amount of research done is very limited and the number of persons suffering from this type of diseases are increasing especially in developing countries like India, China etc. So there is a need to develop an early screening system for the correct multiclass classification into Alzheimer's, Parkinson's and Normal or Healthy control cases. The Alzheimer disease and Parkinson progression (ADPP) dataset is used in this research study for the training of the proposed Neurodegenerative diseases-Caps system. This ADPP dataset is developed with the aid of both the Parkinson's Progression Markers Initiative (PPMI) and Alzheimer's disease Neuroimaging Initiative (ADNI) databases. There is no such early screening system exist yet, which can perform the accurate classification of these two Neurodegenerative diseases. For the sake of genuine comparison, other popular deep transfer learning models like VGG19, VGG16, ResNet50 and InceptionV3 are implemented and also trained over the same ADPP dataset. The proposed Neurodegenerative diseases-Caps system deliver accuracies of 97.81, 98, 96.81% for the Alzheimer, Parkinson and Healthy control or Normal cases with 70/30 (training/validation split) and performs way better as compare to the other popular Deep transfer learning models., Supplementary Information: The online version contains supplementary material available at 10.1007/s11571-022-09787-1., Competing Interests: Conflict of interestThe authors declare that they have no conflict of interest., (© The Author(s), under exclusive licence to Springer Nature B.V. 2022.)