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2 results on '"Caméléna F"'

1. Evolution, control and success of combination therapy with Ampicilin-sulbactam/Ceftazidime-Avibactam during a Carbapenem-Resistant Acinetobacter baumannii outbreak in burn Intensive Care Unit.

Author

Dudoignon E, Caméléna F, Lafaurie M, Deniau B, Chaussard M, Coutrot M, Guillemet L, Cupaciu A, Pharaboz A, Boutin L, Benyamina M, Chaouat M, Mimoun M, Merimèche M, Mebazaa A, Plaud B, Berçot B, Dépret F, and Mellon G

Subjects
Humans, Male, Female, Middle Aged, Adult, Burns complications, Burns microbiology, Drug Therapy, Combination, Treatment Outcome, Aged, Cross Infection microbiology, Cross Infection drug therapy, Cross Infection epidemiology, Drug Resistance, Multiple, Bacterial genetics, beta-Lactamases genetics, Burn Units, Acinetobacter baumannii drug effects, Acinetobacter baumannii genetics, Acinetobacter baumannii isolation & purification, Acinetobacter Infections drug therapy, Acinetobacter Infections microbiology, Acinetobacter Infections epidemiology, Disease Outbreaks, Anti-Bacterial Agents therapeutic use, Anti-Bacterial Agents pharmacology, Azabicyclo Compounds therapeutic use, Azabicyclo Compounds pharmacology, Intensive Care Units, Sulbactam therapeutic use, Sulbactam pharmacology, Drug Combinations, Carbapenems pharmacology, Carbapenems therapeutic use, Ceftazidime therapeutic use, Ceftazidime pharmacology
Abstract

We present our findings on interpatient transmission, epidemic control measures, and the outcomes of a series of ten critically ill burn patients who were either colonized or infected with carbapenem-resistant Acinetobacter baumannii (CRAB). None of the five infected patients achieved clinical cure, and all experienced relapses. Microbiological failure was observed in 40% of the infected patients. The isolated CRAB strains were found to carry bla OXA-23 and armA resistance genes. Despite the lack of clinical cure, all five infected patients survived and were discharged from the Burn Intensive Care Unit., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Published
2024
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2. Inoculum effect of Enterobacterales co-expressing OXA-48 and CTX-M on the susceptibility to ceftazidime/avibactam and meropenem.

Author

Mizrahi A, Chat L, Danjean M, Mory C, Nguyen Van JC, de Ponfilly GP, Caméléna F, Le Monnier A, Bercot B, Birgy A, Jacquier H, and Pilmis B

Subjects
Drug Combinations, Meropenem pharmacology, Microbial Sensitivity Tests, beta-Lactamase Inhibitors pharmacology, beta-Lactamases genetics, Anti-Bacterial Agents pharmacology, Azabicyclo Compounds pharmacology, Ceftazidime pharmacology, Enterobacteriaceae drug effects
Abstract

Background: The treatment of infections caused by OXA-48/CTX-M-coproducing Enterobacterales may be based on new beta-lactam/beta-lactamase inhibitors, such as ceftazidime/avibactam (CZA), or on high dose of meropenem (MER). However, bacterial density at the infection site may vary widely, and the inoculum effect of such antimicrobial strategies has never been specifically investigated. To determine if CZA or MER susceptibilities are impacted by high inocula of Enterobacterales co-expressing both enzymes: OXA-48 like and CTX-M., Methods: Determination of an inoculum effect was performed with a standard inoculum of 10 8  CFU/mL (0.5 McFarland) as recommended by EUCAST guidelines and compared to a twofold increase as well as a tenfold increase (1 McFarland and 5 McFarland respectively)., Results: Thirty-nine isolates of ceftazidime-resistant Enterobacterales were included of which 27 (70%) co-expressed OXA-48 + CTX-M-15, 6 (15%) OXA-48 + CTX-M-14, and 6 (15%) OXA-181 + CTX-M-15. The susceptibility to the CZA combination was preserved whatever the inoculum used. Regarding MER, 24 (61.5%) of the isolates were susceptible to MER with the standard inoculum, 19 (48.7%) with a twofold increase, and only 15 (38.5%) with a tenfold increase., Conclusion: We showed that in vitro inoculum effect was observed with meropenem but not with CZA for OXA-48- combined with CTX-M-producing Enterobacterales., (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Published
2022
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