1. Impact of a dedicated cardiac protocol on diagnosis of infective endocarditis in patients undergoing [ 18 F]-FDG-thoracic digital-PET/CT - Effects of expertise level.
- Author
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Notohamiprodjo S, Scheidhauer K, Eiber M, Yakushev I, Villagran Asiares A, Kraus-Deuringer J, Krebs-Fleischmann HWA, Kleiner S, Eggerstedt R, Eglseder B, Weber WA, and Nekolla SG
- Subjects
- Humans, Female, Male, Middle Aged, Aged, Adult, Sensitivity and Specificity, Reproducibility of Results, Clinical Competence, Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography methods, Endocarditis diagnostic imaging, Radiopharmaceuticals
- Abstract
Background: This study aimed to assess the impact of dedicated cardiac protocol (DCP) on diagnostic accuracy of state-of-the-art digital [
18 F]-FDG-PET/CT in infective endocarditis (IE) and the intra-individual comparison of the performance with that of conventional whole-body approach (WBA) and to analyze the effects of the expertise level of the investigators., Methods: 44 patients suspected for IE underwent digital-FDG-PET/CT after overnight fasting. Each three consultants and trainees reread PET images blinded to the examination approach and clinical information. Visual and semiquantitative analyses were performed., Results: Digital-FDG-PET/CT with DCP revealed sensitivity, specificity, and accuracy of 89%, 93%, and 91% for native valve endocarditis (NVE) and 93%, 86%, and 91% for prosthetic valve endocarditis. Compared to WBA, substantial improvement of the diagnostic performance for NVE in DCP was evident, especially in trainees, but not as high compared to consultants. Digital-FDG-PET/CT enabled 79.5% reclassification of modified-Duke-Clinical-Criteria (mDC) with 34.1% upgrading and 45.4% downgrading., Conclusions: This study provides new data using state-of-the-art digital-FDG-PET/CT with DCP improving the diagnostic accuracy in challenging cases of possible IE, particularly in NVE, provided that the investigators involved have the necessary expertise. These findings may have a significant impact on IE-related morbidity, mortality, and patient's management and might be meaningful for updates on the prevailing opinion regarding the value of FDG PET/CT in NVE., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)- Published
- 2024
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