1. Plasma Cytokines Profile in Patients with Parkinson's Disease Associated with Mutations in GBA Gene.
- Author
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Miliukhina IV, Usenko TS, Senkevich KA, Nikolaev MA, Timofeeva AA, Agapova EA, Semenov AV, Lubimova NE, Totolyan AA, and Pchelina SN
- Subjects
- Aged, Case-Control Studies, Chemokine CCL2 blood, Chemokine CCL2 genetics, Chemokine CCL2 immunology, Enzyme-Linked Immunosorbent Assay, Female, Gene Expression, Glucosylceramidase blood, Glucosylceramidase immunology, Humans, Inflammation, Interferon-gamma blood, Interferon-gamma genetics, Interferon-gamma immunology, Interleukin-13 blood, Interleukin-13 genetics, Interleukin-13 immunology, Interleukin-1beta blood, Interleukin-1beta genetics, Interleukin-1beta immunology, Interleukin-2 blood, Interleukin-2 genetics, Interleukin-2 immunology, Male, Middle Aged, Parkinson Disease blood, Parkinson Disease immunology, Parkinson Disease pathology, Tumor Necrosis Factor-alpha blood, Tumor Necrosis Factor-alpha genetics, Tumor Necrosis Factor-alpha immunology, Glucosylceramidase genetics, Mutation, Parkinson Disease genetics
- Abstract
Plasma cytokine concentration in patients with Parkinson's disease and mutation in GBA gene, in patients with sporadic Parkinson's disease, and in healthy volunteers were measured by ELISA and multiplex analysis. In patients with Parkinson's disease and mutation in GBA gene, elevated plasma concentrations of IL-1β and TNFα were revealed by ELISA in comparison with both controls and patients with sporadic form of Parkinson's disease. Multiplex analysis revealed enhanced secretion of IL-1β, IL-2, IFNγ and reduced plasma levels of monocyte chemoattractant protein-1 (MCP-1) in patients with Parkinson's disease and mutation in GBA gene (in comparison with other groups) and increased plasma levels of IL-13 (only in comparison with the healthy volunteers). Our results support the hypothesis that the concentrations of inflammatory mediators are increased in patients with Parkinson's disease and mutation in GBA gene.
- Published
- 2020
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