1. Left atrial expansion index is an independent predictor of diastolic dysfunction in patients with preserved left ventricular systolic function: A three dimensional echocardiography study
- Author
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Gulsum Sahin, Cihangir Kaymaz, Nihal Özdemir, Suzan Hatipoglu, Tuba Unkun, Mehmet Onur Omaygenç, Gamze Babur Güler, Gökhan Kahveci, and Ruken Bengi Bakal
- Subjects
Male ,Cardiac Catheterization ,medicine.medical_specialty ,Diastolic Dysfunction ,Systole ,Left Atrial Volume ,medicine.medical_treatment ,Echocardiography, Three-Dimensional ,Diastole ,Left Ventricular end Diastolic Pressure ,Ventricular Function, Left ,Ventricular Dysfunction, Left ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,Mitral valve ,Odds Ratio ,Ventricular Pressure ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Heart Atria ,Aged ,Cardiac catheterization ,Ejection fraction ,business.industry ,Age Factors ,Reproducibility of Results ,Stroke Volume ,Stroke volume ,Middle Aged ,Echocardiography, Doppler ,Preload ,medicine.anatomical_structure ,Hypertension ,Multivariate Analysis ,Cardiology ,End-diastolic volume ,Atrial Function, Left ,Female ,Real-Time Three-Dimensional Echocardiography ,Cardiology and Cardiovascular Medicine ,business - Abstract
WOS: 000342453600015 PubMed ID: 24958524 In the absence of mitral valve disease left atrial (LA) volume is a marker of diastolic dysfunction and its severity. This study investigated the relationship between left ventricular (LV) end diastolic pressure (LVEDP) and LA volumes and phasic atrial functions detected by real-time full volume three-dimensional echocardiography (RT3DE), in a patient population with preserved LV systolic function. Seventy-two (39 female and 33 male; mean age 56.1 +/- A 9.0 years) stable patients with normal LV ejection fraction (EF) undergoing cardiac catheterization were studied. All patients underwent comprehensive echocardiographic examination just before catheterization and LVEDP was obtained. In addition to conventional echocardiographic measurements and Doppler indices; by using RT3DE LA maximum, minimum and pre-a-wave volumes were measured; LA total, passive and active emptying volumes and fractions were calculated. LV systolic function was assessed by EF and global longitudinal strain by speckle tracking. RT3DE minimum LA volume index, RT3DE active LAEF and LA expansion index (EI) were statistically significant univariate predictors of LVEDP a parts per thousand yen 16 mmHg. When age and hypertension adjusted multivariate analysis was performed EI [beta = -1.741, p = 0.015; OR 0.175; 95 % CI (0.043-0.717)] was an independent predictor of elevated LVEDP. RT3DE evaluation of LA function during entire cardiac cycle has incremental value for the diagnosis of diastolic dysfunction in patients with preserved EF. We suggest that RT3DE evaluation of LA may find clinical application in this field.
- Published
- 2014