1. Prevalence and Risk Factors of Acute Kidney Injury After Colorectal Cancer Surgery.
- Author
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Abdulgalil AE, Metwally IH, Zuhdy M, Alghandour R, Hasan S, Tarabeah S, Shahda E, and Awny S
- Subjects
- Humans, Male, Female, Risk Factors, Middle Aged, Prevalence, Egypt epidemiology, Postoperative Complications epidemiology, Postoperative Complications etiology, Aged, Adult, Neoadjuvant Therapy adverse effects, Retrospective Studies, Incidence, Colorectal Neoplasms surgery, Acute Kidney Injury epidemiology, Acute Kidney Injury etiology
- Abstract
Purpose: Acute kidney injury is a sentinel event affecting colorectal cancer patients either as a consequence of surgery or systemic chemotherapy. It is highly correlated with both short and long-term adverse outcomes. This work aimed to study the prevalence, risk factors, and impact on survival of postoperative (PO-AKI) and post-chemotherapy (PC-AKI) after colorectal cancer (CRC) surgery in Egyptian patients., Methods: Data of the patients with CRC who underwent surgery over the previous 5 years was retrieved from an internet-based medical system. The incidence of PO-AKI and PC-AKI was calculated, the rate and time to resolution of PO-AKI were recorded, and the possible predictors of AKI were assessed using univariate and multivariate analysis; also, the impact of AKI on patients' survival was tested using survival curves., Results: Five hundred sixty-one cases fulfilled the inclusion criteria and were included in the study. PO-AKI was detected in 10.5% of the patients. Significant risk factors included intraoperative hypotension, sepsis, hypoalbuminemia, amount of intraoperative bleeding, neoadjuvant therapy, and preoperative chronic kidney disease (CKD). However, only neoadjuvant treatment (hazard ratio (HR) 2.2) and CKD (HR 3.3) maintained significant risk in the multivariate analysis. PC-AKI was observed in 18.7% of the patients treated. Significant risk factors were previous CKD and the chemotherapy type, mainly affecting those who received Irinotecan-based therapy. The hazard ratio was 8.5 and 2.4 respectively, in multivariate analysis. The overall survival was significantly worse in those who developed PO- or PC-AKI (pā<ā0.001)., Conclusion: AKI affects more than 25% of CRC patients after surgery and/or chemotherapy. Modifiable risk factors include preoperative hypoalbuminemia, intraoperative bleeding, and/or intraoperative hypotension. While, the more important risk factors were non-modifiable including CKD, neoadjuvant therapy, and Irinotecan-containing regimens. Most kidney injuries are stage I; however, they are associated with shorter overall survival., Competing Interests: Declarations. Ethics Approval and Consent to Participate: The study protocol was approved by the Mansoura Faculty of Medicine institutional review board (MFM-IRB) (approval number: R.22.01.1578). This work has been carried out in concordance with The Code of Ethics of the World Medical Association (Declaration of Helsinki) for studies involving humans. Consent for Publication: Not applicable. Competing Interests: The authors declare no competing interests., (© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2025
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