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Reservoir construction is the key strategy for water resource management. In recent years, the migration of pollutants and their transformation into the reservoir ecosystem has become a global problem. Intensified anthropogenic activities and unsustainable practices have amplified the pollutant levels in the reservoir. Therefore, this book intends to highlight environmental characteristics of the reservoir, study methods of ecotoxicology, and mechanistic toxicogenetic pathways of pollutants in the reservoir. Adverse outcome pathway (AOPs) model is used to elucidate toxicological effects of reservoir pollutants. Moreover, ecological and human health risks of the Three Gorges Reservoir (TGR), the largest power generation reservoir on earth, and its pollution status are also discussed.

The book offers a comprehensive and didactic overview of both advanced diagnostic and therapeutic endoscopy imaging techniques, with a clinical impact correspondent in major gastroenterology, hepatology, and pancreatology diseases.It includes state-of-the art techniques like endoscopic ultrasound and confocal laser endomicroscopy, as well as endoscopic retrograde cholangio-pancreatography. Divided into 9 main chapters, the book covers the examination techniques, the sedation and monitoring, and investigates the clinical impact of endoscopy. Specific chapters are dedicated to the upper gastrointestinal tract, the lower gastrointestinal tract, to pancreatico-biliary diseases and to liver diseases. Enriched by more than 400 original images based on 25 years'experience in the field of advanced endoscopy imaging, and accompanied by carefully selected videos, this volume will be a reference guide for residents and trainees in gastroenterology, hepatology, pancreatology,and surgery, with emphasis on endoscopy techniques.

There have been many advances in the diagnosis and treatment of cancer, but it is still a feared disease with a lot of work left to be done. The importance of gastrointestinal cancer as a frequently occurring disease goes without saying. It accounts for half of human cancer cases but differs from other forms of cancer. Complete prevention is possible through proper treatment of precancerous lesions. There is still no comprehensive book about prevention, early diagnosis, and proper treatment of precancerous lesions and new developed diagnostic modality, and treatment such as endoscopic treatment and minimal invasive surgery and chemotherapy and immunotherapy. Also, this book will contain conservative treatment methods for patients suffering from diverse complications. There will be plentiful clinical cases including endoscopic findings, radiologic images, pathology and treatment outcome in this book. For these reasons, this book will give very valuable information to many gastroenterologists, oncologists, surgeons and general physicians.

The AFS Textbook of Foregut Disease serves as a comprehensive guide of information covering the fast-evolving field of foregut disease. This textbook is designed as a partnership between gastroenterologists & gastrointestinal surgeons with an understanding that an essential component of moving forward in this field is through collaboration. This AFS textbook has been developed by the American Foregut Society, a premier society for foregut disease and all chapters are written by experts in the field. Readership is intended for gastroenterologists, GI and thoracic surgeons, gastroenterology and general surgery residents and fellows, medical students, and integrated health members that manage foregut disease. All chapters follow an organized format that contains many graphs, tables, intraoperative photographs, and illustrations of techniques. This textbook provides the most up-to-date scientific information and will be the definitive resource to guide both the diagnosis and management of foregut disease for years to come.

This book is a comprehensive guide to the surgery-first orthognathic approach for patients with malocclusion and skeletal disharmony, which has been successfully applied by the authors in their practices over the past 15 years. The approach breaks with the time-tested principles of traditional orthognathic surgery in that corrective bone surgery is performed first, without the removal of dental compensations, followed by orthodontic finishing. All aspects are covered with the aid of numerous illustrations, the aim being to provide surgeons with a systematic educational tool that will enable them to introduce the approach into their own practice. In addition, the book addresses one of the hot issues in orthodontics, occlusal plane-altering orthognathic surgery, in which surgical modification of the occlusal plane is employed to treat various types of dentofacial deformity and improve facial proportions. This promises to become a very powerful tool in modern orthognathic surgery.

This volume provides a concise yet comprehensive overview of advanced techniques in interventional endoscopy beyond ERCP and EUS. Comprised of sections on endoscopic resection (including EMR, ESD, STER and EFTR), bariatric endoscopy, endoscopic myotomy (POEM, GPOEM, ZPOEM and PREM), endoscopic anti-reflux therapies, endoscopic tissue apposition, and advances in interventional EUS, the text highlights indications and technical details, assesses safety and efficacy, and provides quality metrics and training pathways for these endoscopic procedures. The book is also accompanied by multiple photos and videos illustrating these endoscopic techniques. Written by world renowned experts in the field, Gastrointestinal Interventional Endoscopy: Advanced Techniques is a valuable resource for gastroenterologists and surgeons interested in the latest advances in interventional endoscopy.

This book provides a comprehensive and up-to-date review of current understanding of periostin and its importance for human health and disease. Periostin is a secretory matricellular protein that has been revealed to play key roles in fibrillogenesis and cell migration, including metastasis of cancer cells. The production of periostin is upregulated during fibrotic responses and the mechanisms by which it promotes fibrosis have become a focus of interest owing to the potential clinical benefit to be derived from periostin blockade. In this book, readers will find coverage of all aspects, from the basic properties of periostin and its function as a scaffold for assembly of extracellular proteins through to its roles in bone and tissue regeneration, tumorigenesis, myocardial infarction, inflammatory and immune system disorders, and other diseases. Readers will also find the latest information on functions of periostin related to stemness and the application of periostin as a biomarker. It is hoped that the detailed knowledge of periostin and its pathobiological significance provided in this book will aid in the search for effective treatments for currently incurable diseases.

This book, written by world authorities in the field, is a comprehensive, up-to-date guide to the specialty of Oral Medicine, which is concerned with the diagnosis, prevention, and predominantly non-surgical management of medically related disorders and conditions affecting the oral and maxillofacial region. The pathophysiology, clinical presentation, diagnostic evaluation, and treatment of all relevant diseases and disorders are described with the aid of a wealth of clinical cases and illustrations that enable the reader to appreciate the diversity and potential complexity of Oral Medicine. In addition to the wide-ranging coverage of oral conditions, separate sections are devoted to bone and cutaneous pathology and to orofacial pain and its management, in addition to dental sleep medicine. The clinician who treats Oral Medicine patients will find this book to be an excellent aid to optimal management grounded in a sound knowledge of basic science and the dental and medical aspects ofeach disorder. In addition, it will serve as an outstanding textbook for undergraduate and postgraduate students.

This comprehensive volume explores functions, pathologies, and applications of stem cells in relation to the niches in which they develop. Ten chapters cover the subject in depth, from a historical perspective through signaling, hormonal control, quiescence, biomimetics, epigenetics, engineering strategies for emulating, tumorigenesis and more. The chapter authors represent a broad range of international expertise and perspectives.This installment of the popular Stem Cell Biology and Regenerative Medicine series delivers authoritative, international perspectives on this rapidly growing field. Biology of Stem Cell Niche is an ideal complementary volume to Tissue-Specific Stem Cell Niche and Adult Stem Cells, Second Edition and will be invaluable to clinicians and researchers working with stem cells as well as to postgraduate trainees who are studying them.

Auf dem Gebiet der Oralpathologie sind durch die Einbeziehung moderner Methoden der allgemeinen Pathologie in die Forschungsprojekte und in die praktische Routinediagnostik entscheidende Fortschritte erzielt worden. Gleichzeitig traten neue, international begründete Klassifikationen der verschiedenen Organkrankheiten in Kraft.Diesen Entwicklungen trägt das Werk'Oralpathologie'Rechnung. Es umfaßt das gesamte aktuelle Wissen dieses Fachgebiets in einer Fülle und Form, die im deutschsprachigen Raum einzigartig ist. Es stellt den modernen Standard dar, auf den Pathologen und Kliniker nicht verzichten können.Oralpathologie I berücksichtigt:- Klassifikation der Sialadenitis und Speicheldrüsentumoren mit modernen Methoden,- die aktuellen Ergebnisse der Immunhistochemie, Molekularbiologie und Prognosefaktoren,- die neueste WHO-Nomenklatur der Speicheldrüsentumoren,- klinische und therapeutische Gesichtspunkte,- Speicheldrüsenkrankheiten, insbesondere Tumoren, im Kindesalter,- die neueste Literatur bis November 1995.Das Werk zeichnet sich durch eine klare und übersichtliche Gliederung des Stoffes aus. Eine Fülle herausragender, zum großen Teil farbiger Abbildungen sowie instruktive Tabellen und Übersichten veranschaulichen den prägnanten Text.Die inhaltliche Gliederung erfolgt nach klinischen Aspekten: - Definition und Klassifikation,- klinische und statistische Daten,- Pathohistologie und Pathogenese,- Immunzytochemie und Ultrastruktur,- Prognose und Differentialdiagnose.Dieses aussagekräftige Nachschlagewerk bietet Ihnen rasche, zuverlässige Orientierung im klinisch-praktischen Alltag.

This book describes clearly various research topics investigated for these 10 years in the Research Center of Advanced Structural and Functional Materials Design in Osaka University, Japan. Every chapter is aimed at understanding most advanced researches in materials science by describing its fundamentals and details as much as possible. Since both general explanations and cutting-edge commentaries are given for each topic in this book, it provides a lot of useful information for ordinary readers as well as materials scientists & engineers who wish to understand the future development in materials science fields of metals, alloys, ceramics, semiconductors etc. In particular, this book deals with special fusion area of structural and functional materials such as medical bone materials, of which contents are very unique features as materials science textbook.

Die Speicheldrüsen sind in mannigfacher Weise in den Organismus eingebunden, so daß aus der Analyse des Speichels Rückschlüsse auf krankhafte Funktionen anderen Organsysteme gezogen werden können. Wechselwirkungen zwischen Speicheldrüsen und Organismus spielen in der Ätiologie und Pathogenese der verschiedenen Formen der Sialadenitis eine bedeutsame Rolle. Hierzu gehören Immunkrankheiten, metabolische Erkrankungen, hormonale Dysfunktionen, neurologische und auch genetische Erkrankungen. Auf dem Gebiet der Speicheldrüsentumoren sind durch den Einsatz neuer Methoden (Immunhistochemie, Molekularpathologie, Prolifikationsmarker, Chromosomenanalyse) viele neue Erkenntnisse gesammelt worden.

The field of regenerative medicine has developed rapidly over the past 20 years with the advent of molecular and cellular techniques. This textbook, Regenerative Medicine: From Protocol to Patient, aims to explain the scientific knowledge and emerging technology as well as the clinical application in different organ systems and diseases. International leading experts from four continents describe the latest scientific and clinical knowledge of the field of regenerative medicine. The process of translating science of laboratory protocols into therapies is explained in sections on regulatory, ethical and industrial issues. This textbook is organized into five parts: (I) Biology of Tissue Regeneration, (II) Stem Cell Science and Technology, (III) Tissue Engineering, Biomaterials and Nanotechnology, (IV) Regenerative Therapies and (V) Regulation and Ethics. The textbook aims to give the student, the researcher, the health care professional, the physician and the patient a complete survey on the current scientific basis, therapeutical protocols, clinical translation and practiced therapies in regenerative medicine.

This book contains a selection of the papers presented at the meeting'Between Clone and Clinic'which was organised in March 1990 in Amsterdam by the dutch Organisation for Applied Research, TNO, and the University of Utrecht. The scope of this meeting was the development of biotechnological pharmaceuticals mainly made by recombinant DNA technology or monoclonal antibody techniques. All aspects concerning the development of the products after host cells producing them are obtained where discussed. The meeting was attended by twohundred specialists from all over the globe, including phar­ macologists, toxicologists, registration experts, Quality Assurence managers, production en­ gineers and physicians. Biotechnological pharmaceuticals are in general large and complex protein molecules. Bringing these products to the market poses other problems than encountered with the classical chemical drugs. The source of biotechnological pharmaceuticals are living cells. The function of cells are depend­ ent on many factors and the stability of production may be a problem. Good Laboratory and Manufactory Practices with Quality Control (GLP and GMP) are of paramount importance and are discussed in a number of papers. The products of the new biotechnology are often highly specific and only active in the human species. Also the side effects can only be studied in the clinical setting. Even when the product is active in animals there is the problem of antigenicity. During treatment the animals will produce antibodies which neutralise the activity. So safety testing may prove difficult.

Regenerative Medicine is a fastly emerging interdisciplinary field of research and clinical therapies on the repair, replacement or regeneration of cells, tissues or organs in congenital or acquired disease. This new field of research and clinical development focussing on stem cell science and regenerative biology is just starting to be the most fascinating and controversial medical development at the dawn of the 21st century. Viewing the great expectations to restructure and regenerate tissue, organs or organisms the current attempts of scientist and physicians are still in an early phase of development. This new textbook on “Regenerative Medicine – from protocol to patient” is aiming to explain the scientific knowledge and emerging technology as well as the clinical application in different organ systems and diseases. The international leading experts from four continents describe the latest scientific and clinical knowledge of the field of “Regenerative Medicine”. The process of translating science of laboratory protocols into therapies is explained in sections on basic science, clinical translation, regulatory, ethical and industrial issues. The textbook is aiming to give the student, the researcher, the health care professional, the physician, and the patient a complete survey on the current scientific basis, therapeutical protocols, clinical translation and practised therapies in Regenerative Medicine.

This volume analyzes and summarizes recent developments in several key interfacial electrochemical systems in the areas of fuel cell electrocatatalysis, electrosynthesis and electrodeposition. The six Chapters are written by internationally recognized experts in these areas and address both fundamental and practical aspects of several existing or emerging key electrochemical technologies. The Chapter by R. Adzic, N. Marinkovic and M. Vukmirovic provides a lucid and authoritative treatment of the electrochemistry and electrocatalysis of Ruthenium, a key element for the devel- ment of efficient electrodes for polymer electrolyte (PEM) fuel cells. Starting from fundamental surface science studies and interfacial considerations, this up-to-date review by some of the pioneers in this field, provides a deep insight in the complex catalytic-electrocatalytic phenomena occurring at the interfaces of PEM fuel cell electrodes and a comprehensive treatment of recent developments in this extremely important field. Several recent breakthroughs in the design of solid oxide fuel cell (SOFC) anodes and cathodes are described in the Chapter of H. Uchida and M. Watanabe. The authors, who have pioneered several of these developments, provide a lucid presentation d- cribing how careful fundamental investigations of interfacial electrocatalytic anode and cathode phenomena lead to novel electrode compositions and microstructures and to significant practical advances of SOFC anode and cathode stability and enhanced electrocatalysis.