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2 results on '"Smirnova MP"'

1. Correction of changes in ADP-induced platelet aggregation with vasopressin analogue desglycinamide-arginine-vasopressin.

Author

Golubeva MG, Grigoreva ME, and Smirnova MP

Subjects
Animals, Arginine Vasopressin pharmacology, Blood Platelets drug effects, Clopidogrel, Hemostasis drug effects, Hemostatics pharmacology, Platelet Aggregation Inhibitors pharmacology, Platelet Function Tests, Rats, Ticlopidine analogs & derivatives, Ticlopidine pharmacology, Adenosine Diphosphate metabolism, Arginine Vasopressin analogs & derivatives, Platelet Aggregation drug effects, Vasopressins chemistry
Abstract

We studied the effect of vasopressin analogue desglycinamide-arginine-vasopressin on changes in platelet hemostasis produced by intragastric administration of Ticlid or clopidogrel (inhibitors of ADP-induced platelet aggregation). Intranasal administration of the peptide under conditions of hemorrhagic diathesis produced a hemostatic effect and normalized some parameters of blood coagulation.

Published
2005
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2. Antipyretic effect of neuropeptide galanin in endotoxin-induced fever.

Author

Lyudyno VI, Krasnova IN, Smirnova MP, and Klimenko VM

Subjects
Animals, Body Temperature physiology, Chromatography, High Pressure Liquid, Fever chemically induced, Galanin pharmacology, Hypothalamus, Anterior metabolism, Lipopolysaccharides, Male, Neurotransmitter Agents metabolism, Rats, Rats, Wistar, Fever drug therapy, Galanin therapeutic use
Abstract

Neuropeptide galanin produces a antipyretic effect in experimental pyrogenic reaction induced by intraperitoneal injection of lipopolysaccharide. Central intracerebroventricular injection of 100 ng galanin significantly attenuated, but did not completely abolish fever. Central galanin injection potentiated endotoxin-induced activation of the noradrenergic system and blocked activation of the serotoninergic system of the anterior hypothalamus.

Published
2001
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