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Classic of Changes is a Chinese cultural classic born more than 3000 years ago. Its profound philosophical thoughts and the use of divination have brought Classic of Changes to a strong oriental mysticism. The view of the heaven and man of yin and yang and the five elements states of Classic of Changes are completely different from the Western elemental theory of ancient Greece. The latter gave birth to classical and modern scientific theories, and the yin and yang and the eight trigrams symbol has become synonymous with oriental mysticism. In fact, the cosmology of the Holism of Classic of Changes is a precious scientific heritage of mankind. The axiomatization of the symbolic formal system of Classic of Changes aims to unveil the veil of oriental mysticism and provide oriental wisdom for the development of modern science. Transforming the symbolic system of Classic of Changes into a formal axiom system is the crystallization of the fusion of wisdom between the East and the West. The axiomatization of the symbolic formal system of Classic of Changes shows that the oriental and the western scientific tradition harmony but not sameness and there is no conflict. Classic of Changes can also be interpreted by the axiomatic system like Euclid's Elements. The main contribution of this paper is that the author skillfully uses mathematical language to formulate the system of Classic of Changes, reconstructs the ideological system of Classic of Changes with the axiomatic method and realizes the scientificalization of Chinese classical natural philosophy. The formal axiom system of Classic of Changes may give us such a revelation: the gap between the oriental and western scientific traditions is mainly in the axiomatization, but the lack of oriental scientific tradition may be the bottleneck of the development of modern science., Author(s): Xijia Wang [sup.1] Author Affiliations: (1) grid.411427.5, 0000 0001 0089 3695, College of Mathematics and Statistics, Hunan Normal University, , 410081, Changsha, China Introduction Formalization and axiomatization are the [...]

Background: Circular RNAs (circRNA) have been reported to be involved in the progression of cerebral infarction. The purpose of this study was to reveal the role and potential molecular mechanism of circZfp609 (mmu_circ_0001797) in cerebral infarction., Methods: C57BL/6J mice was used to construct middle cerebral artery occlusion (MCAO) mice model, and primary mouse astrocytes were treated with oxygen-glucose deprivation/reperfusion (OGD/R) process. The circZfp609, microRNA (miR)-145a-5p and BTB and CNC homology 1 (BACH1) expression levels were detected by quantitative real-time PCR. Cell proliferation and apoptosis were assessed by cell counting kit 8 assay, EdU assay and flow cytometry. Western blot analysis was used to measure protein levels, and ELISA assay was utilized to detect the levels of inflammation factors. Lactate dehydrogenase (LDH) level was measured by LDH Assay Kit. Dual-luciferase reporter assay, RIP assay and RNA pull-down assay were used to evaluate RNA interaction., Results: CircZfp609 was upregulated in MCAO mice and OGD/R-induced astrocytes. Knockdown of circZfp609 promoted cell proliferation, while suppressed apoptosis and inflammation in OGD/R-induced astrocytes. CircZfp609 served as a sponge for miR-145a-5p, and miR-145a-5p inhibitor reversed the regulation of circZfp609 knockdown on OGD/R-induced astrocyte injury. BACH1 was a target of miR-145a-5p, and its overexpression abolished the inhibition effect of miR-145a-5p on OGD/R-induced astrocyte injury. Besides, circZfp609 downregulation also relieved the brain injury of MCAO mice through miR-145a-5p/BACH1 axis., Conclusion: Our data showed that circZfp609 might promote cerebral infarction by regulating the miR-145a-5p/BACH1 pathway., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

This study aimed to determine the most suitable site for diagnosis of carpal tunnel syndrome (CTS) by examining an 8-site measurement of the median nerve's cross-sectional area (CSA). A total of 36 wrists of 26 patients with nerve conduction study (NCS) proven CTS, along with 34 wrists of 23 controls whose age and gender were matched with the patients, were evaluated with ultrasonography. The CSAs of the median nerve at eight predetermined sites including at the sites of 3, 2, and 1 cm proximal to the wrist crease, wrist crease, as well as at the sites of 1, 2, 3. and 4 cm distal to the wrist crease were obtained. The correlation between CSA and NCS severity, and duration of clinical CTS symptoms was analyzed. Receiver operating characteristic (ROC) curves was applied to determine the optimum cut-off point and to evaluate the diagnostic sensitivity and specificity of sonographic measurements. The CSAs of the median nerves at the eight sites were significantly higher in the CTS subjects, relative to the controls. Moreover, anatomical variation of the median nerve was found in the CTS group. ROC results indicated the areas under curve (AUC) at the site of 4 cm distal to the wrist crease were the largest with 0.874 cm(2), and an optimal cut-off value of 0.095 yielded a sensitivity of 88.9 % and a specificity of 76.5 %. The CSAs of "CTS-wrists" positively correlated with NCS severities and the CTS symptoms duration. Using 8-site CSAs measurement of the median nerve from inlet to outlet has positive correlations with NCS severity and duration of CTS symptoms.