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15 results on '"ANDRIA, GENEROSO"'

1. Vitamin E Improves Clinical Outcome of Patients Affected by Glycogen Storage Disease Type Ib

Author

Melis, Daniela, Minopoli, Giorgia, Balivo, Francesca, Marcolongo, Paola, Parini, Rossella, Paci, Sabrina, Dionisi-Vici, Carlo, Della Casa, Roberto, Benedetti, Angelo, Andria, Generoso, Parenti, Giancarlo, Morava, Eva, editor, Baumgartner, Matthias, editor, Patterson, Marc, editor, Rahman, Shamima, editor, Zschocke, Johannes, editor, and Peters, Verena, editor

Published
2016
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14. Low-Dose Amitriptyline-Induced Acute Dystonia in a Patient with Metachromatic Leukodystrophy

Author

Ennio Del Giudice, Gaetano Terrone, Gerarda Cappuccio, Nicola Brunetti-Pierri, Generoso Andria, Alfonso Romano, Cappuccio, Gerarda, BRUNETTI PIERRI, Nicola, Terrone, Gaetano, Romano, Alfonso, Andria, Generoso, and DEL GIUDICE, Ennio

Subjects
chemistry.chemical_classification, Arylsulfatase A, Side effect, business.industry, Pharmacology, Irritability, medicine.disease, Article, Metachromatic leukodystrophy, chemistry, Toxicity, medicine, Amitriptyline, medicine.symptom, Adverse effect, business, Tricyclic, medicine.drug
Abstract

Acute dystonia is an abrupt event mainly related to toxicity of drugs such as antiemetics, antipsychotics, anti-acids, and, more rarely, tricyclic antidepressants. Use of amitriptyline in metachromatic leukodystrophy (MLD), a lysosomal storage disorder (LSD) due to arylsulfatase A deficiency, is suggested to control neurological pain and irritability. We describe a patient with MLD who experienced acute dystonia as a side effect of low dosage of amitriptyline. The distribution of psychotropic drugs, including antidepressants, depends upon lysosomal trapping which is inefficient in LSD. The defective lysosomal depot might raise cerebral levels of amitriptyline, thus enhancing its adverse effects.Physicians caring for children with MLD treated with psychotropic drugs should be aware of such adverse events which are potentially related to lysosomal dysfunction. This experience raises a potential concern about the appropriate dose of amitriptyline in patients with MLD.

Published
2012

15. Genetic Risk Factors for Neural Tube Defects: Folic Acid Supplementation and Prevention of Birth Defects

Author

Iris Scala, Generoso Andria, Esposito C, Guys Jean Michel, Gouch David, Savanelli Antonio, Andria, Generoso, and Scala, Iris

Subjects
medicine.medical_specialty, Endocrinology, medicine.anatomical_structure, Neural tube defect, Folic acid, business.industry, Internal medicine, medicine, Neural tube, Genetic risk, business, medicine.disease, Folic acid supplementation
Published
2006

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