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Your search keyword '"Albanese S"' showing total 7 results
Start Over Author "Albanese S" Publisher springer berlin heidelberg
7 results on '"Albanese S"'

1. In vivo imaging of CNS microglial activation/macrophage infiltration with combined [18F]DPA-714-PET and SPIO-MRI in a mouse model of relapsing remitting experimental autoimmune encephalomyelitis

Author

Coda, A. R., Anzilotti, S., Boscia, F., Greco, A., Panico, M., Gargiulo, S., Gramanzini, M., Zannetti, A., Albanese, S., Pignataro, G., Annunziato, L., Salvatore, M., Brunetti, A., De Berardinis, P., Quarantelli, Mario, Palma, G., and Pappatà, Sabina

Published
2021
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2. Kehlkopf, Trachea

Author

Krmpotić-Nemanić, J., Keros, P., Nemanić, G., Vinter, I., Werner, J. A., Schünke, M., Rudert, H., Tillmann, B., Schilling, V., Mischke, D., Lobeck, H., Wild, G. A., Albanese, S., Kleinsasser, O., Glanz, H., Yildiz, F., Bonfils, P., Streinzer, W., Zrunek, M., Gilly, H., Werba, A., Martin, F., Mantel, K., Hof, E., Effenberger, C., von Glaß, W., Weidenbecher, M., Pesch, H.-J., Böhme, G., Rossbach, Th., Würtemberger, G., Schürenberg, B., Kittel, G., Nickol, H.-J., Deichmann, K., Koch, A., Federspil, P., Leidinger, B., Mayer-Brix, J., Becker, H., Mahlo, H.-W., Hannig, Ch., Wuttge-Hannig, A., Fleischer, Konrad, editor, and Wigand, Malte Erik, editor

Published
1988
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3. Video-Präsentation

Author

Weerda, H., Schuderer, R., Rettinger, G., Haid, T., Iro, H., Kachlik, H. G., Goertzen, W., Brusis, T., Pototschnig, C., Schobel, H., Mertens, J., Stammberger, H., Wolf, G., Koidl, B., Saria, A., Arrer, E., Oberascher, G., Berghaus, A., Gundlach, P., Weisemann, J., Clarke, A. H., Axhausen, M., Hörman, K., Renninghoff, J., Meuser, W., Hamann, K.-F., Clasen, B. P. E., Gulden, J., Weiss, D. G., Schroeder, H.-G., Eichhorn, Th., Albanese, S., Kleinsasser, O., Bumm, P., Botev, S., Wengert, P., Draf, W., Strasding, G., Timm, H., Herrmann, I. F., Raschke, D., Hartwein, G., Fleischer, Konrad, editor, and Wigand, Malte Erik, editor

Published
1988
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7. In vivo imaging of CNS microglial activation/macrophage infiltration with combined [18F]DPA-714-PET and SPIO-MRI in a mouse model of relapsing remitting experimental autoimmune encephalomyelitis

Author

Giuseppe Pignataro, Sara Gargiulo, Sabina Pappatà, Marco Salvatore, Matteo Gramanzini, Lucio Annunziato, S. Albanese, Anna Rita Daniela Coda, Mario Quarantelli, Mariarosaria Panico, Antonella Zannetti, Adelaide Greco, F. Boscia, P. De Berardinis, Giuseppe Palma, Serenella Anzilotti, Arturo Brunetti, Coda, A R, Anzilotti, S, Boscia, F, Greco, A, Panico, M, Gargiulo, S, Gramanzini, M, Zannetti, A, Albanese, S, Pignataro, G, Annunziato, L, Salvatore, M, Brunetti, A, De Berardinis, P, Quarantelli, Mario, Palma, G, and Pappatà, Sabina

Subjects
Pathology, medicine.medical_specialty, Encephalomyelitis, Autoimmune, Experimental, Standardized uptake value, 030218 nuclear medicine & medical imaging, Multiple sclerosis, 03 medical and health sciences, Mice, 0302 clinical medicine, TSPO-PET, Neuroinflammation, Positron Emission Tomography Computed Tomography, medicine, Translocator protein, Animals, Multiple sclerosi, Radiology, Nuclear Medicine and imaging, Microglia, biology, business.industry, EAE, Macrophages, Experimental autoimmune encephalomyelitis, SPIO-MRI, General Medicine, Macrophage Activation, medicine.disease, Magnetic Resonance Imaging, medicine.anatomical_structure, Pyrimidines, Positron-Emission Tomography, biology.protein, Pyrazoles, Original Article, Female, business, 030217 neurology & neurosurgery, Preclinical imaging, Ex vivo
Abstract

PurposeTo evaluate the feasibility and sensitivity of multimodality PET/CT and MRI imaging for non-invasive characterization of brain microglial/macrophage activation occurring during the acute phase in a mouse model of relapsing remitting multiple sclerosis (RR-MS) using [18F]DPA-714, a selective radioligand for the 18-kDa translocator protein (TSPO), superparamagnetic iron oxide particles (SPIO), and ex vivo immunohistochemistry.MethodsExperimental autoimmune encephalomyelitis (EAE) was induced in female SJL/J mice by immunization with PLP139–151. Seven symptomatic EAE mice and five controls underwent both PET/CT and MRI studies between 11 and 14 days post-immunization. SPIO was injected i.v. in the same animals immediately after [18F]DPA-714 and MRI acquisition was performed after 24 h. Regional brain volumes were defined according to a mouse brain atlas on co-registered PET and SPIO-MRI images. [18F]DPA-714 standardized uptake value (SUV) ratios (SUVR), with unaffected neocortex as reference, and SPIO fractional volumes (SPIO-Vol) were generated. Both SUVR and SPIO-Vol values were correlated with the clinical score (CS) and among them. Five EAE and four control mice underwent immunohistochemical analysis with the aim of identifying activated microglia/macrophage and TSPO expressions.ResultsSUVR and SPIO-Vol values were significantly increased in EAE compared with controls in the hippocampus (p p p p p p ConclusionsThese preliminary results suggest that both activated microglia and infiltrated macrophages are present in vulnerable brain regions during the acute phase of PLP-EAE and contribute to disease severity. Both [18F]DPA-714-PET and SPIO-MRI appear suitable modalities for preclinical study of neuroinflammation in MS mice models.

Published
2020
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